Sugi Variant

Sugi Variant/SCRIB

SCRIB — 499 ClinVar variants

All ClinVar germline SCRIB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 320 flagged for review →

1 Likely pathogenic · 20 Benign · 2 Benign/Likely benign · 121 Likely benign · 355 Uncertain significance

Full SCRIB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 320

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 260

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 260

Predictors split 60

The independent predictors disagree with each other — read with care.

All SCRIB variants

Likely pathogenic 1

Benign 20

Benign/Likely benign 2

Likely benign 121

Uncertain significance 355

Showing the top 300 by review status; the full set is in the sitemap.