SDC2 — 27 ClinVar variants
All ClinVar germline SDC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
1 Benign · 26 Uncertain significance
Full SDC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SDC2 p.Ala124Gly Uncertain significance Single submitter
- SDC2 p.Ala14Val Uncertain significance Single submitter
- SDC2 p.Arg170Cys Uncertain significance Single submitter
- SDC2 p.Arg170His Uncertain significance Single submitter
- SDC2 p.Arg72Gln Uncertain significance Single submitter
- SDC2 p.Asn95Lys Uncertain significance Single submitter
- SDC2 p.Asp29Asn Uncertain significance Single submitter
- SDC2 p.Cys15Ser Uncertain significance Single submitter
- SDC2 p.Ile150Thr Uncertain significance Single submitter
- SDC2 p.Ile150Val Uncertain significance Single submitter
- SDC2 p.Ile6Thr Uncertain significance Single submitter
- SDC2 p.Ile97Thr Uncertain significance Single submitter
- SDC2 p.Leu114Val Uncertain significance Single submitter
- SDC2 p.Leu158Phe Uncertain significance Single submitter
- SDC2 p.Leu78Arg Uncertain significance Single submitter
- SDC2 p.Lys197Met Uncertain significance Single submitter
- SDC2 p.Lys197Thr Uncertain significance Single submitter
- SDC2 p.Lys28Glu Uncertain significance Single submitter
- SDC2 p.Lys85Arg Uncertain significance Single submitter
- SDC2 p.Met30Lys Uncertain significance Single submitter
- SDC2 p.Thr89Met Uncertain significance Single submitter
- SDC2 p.Thr9Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All SDC2 variants
Benign 1
- p.Ser71Thr Multiple submitters
Uncertain significance 26
- p.Ala124Gly Single submitter ⚠
- p.Ala14Val Single submitter ⚠
- p.Arg170Cys Single submitter ⚠
- p.Arg170His Single submitter ⚠
- p.Arg184His Single submitter ⚠
- p.Arg72Gln Single submitter ⚠
- p.Asn95Lys Single submitter ⚠
- p.Asp29Asn Single submitter ⚠
- p.Asp49Asn Single submitter ⚠
- p.Cys15Ser Single submitter ⚠
- p.Ile150Thr Single submitter ⚠
- p.Ile150Val Single submitter ⚠
- p.Ile6Thr Single submitter ⚠
- p.Ile97Thr Single submitter ⚠
- p.Leu114Val Single submitter ⚠
- p.Leu139Pro Single submitter
- p.Leu158Phe Single submitter ⚠
- p.Leu78Arg Single submitter ⚠
- p.Lys197Met Single submitter ⚠
- p.Lys197Thr Single submitter ⚠
- p.Lys28Glu Single submitter ⚠
- p.Lys85Arg Single submitter ⚠
- p.Met30Lys Single submitter ⚠
- p.Thr89Met Single submitter ⚠
- p.Thr9Ile Single submitter ⚠
- p.Val154Ala Single submitter ⚠