SDC4 — 24 ClinVar variants
All ClinVar germline SDC4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
1 Likely benign · 23 Uncertain significance
Full SDC4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SDC4 p.Ala8Val Uncertain significance Single submitter
- SDC4 p.Arg5Cys Uncertain significance Single submitter
- SDC4 p.Arg92Gly Uncertain significance Single submitter
- SDC4 p.Asp57Asn Uncertain significance Single submitter
- SDC4 p.Glu177Asp Uncertain significance Single submitter
- SDC4 p.Gly153Ala Uncertain significance Single submitter
- SDC4 p.Gly52Arg Uncertain significance Single submitter
- SDC4 p.Gly96Arg Uncertain significance Single submitter
- SDC4 p.Ile27Val Uncertain significance Single submitter
- SDC4 p.Ser138Gly Uncertain significance Single submitter
- SDC4 p.Val111Phe Uncertain significance Single submitter
- SDC4 p.Val135Gly Uncertain significance Single submitter
- SDC4 p.Val162Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- SDC4 p.Ala198Thr Uncertain significance Single submitter
- SDC4 p.Ala198Val Uncertain significance Single submitter
- SDC4 p.Arg171Cys Uncertain significance Single submitter
- SDC4 p.Arg171His Uncertain significance Single submitter
- SDC4 p.Arg22Gly Uncertain significance Single submitter
- SDC4 p.Lys175Arg Uncertain significance Single submitter
- SDC4 p.Val156Met Uncertain significance Single submitter
All SDC4 variants
Likely benign 1
- p.Gly75Ser Single submitter
Uncertain significance 23
- p.Ala198Thr Single submitter ⚠
- p.Ala198Val Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg171Cys Single submitter ⚠
- p.Arg171His Single submitter ⚠
- p.Arg22Gly Single submitter ⚠
- p.Arg5Cys Single submitter ⚠
- p.Arg92Gly Single submitter ⚠
- p.Asp181His Single submitter
- p.Asp45Asn Single submitter
- p.Asp57Asn Single submitter ⚠
- p.Glu177Ala Single submitter
- p.Glu177Asp Single submitter ⚠
- p.Gly153Ala Single submitter ⚠
- p.Gly52Arg Single submitter ⚠
- p.Gly96Arg Single submitter ⚠
- p.Ile27Val Single submitter ⚠
- p.Lys175Arg Single submitter ⚠
- p.Ser138Gly Single submitter ⚠
- p.Val111Phe Single submitter ⚠
- p.Val135Gly Single submitter ⚠
- p.Val156Met Single submitter ⚠
- p.Val162Ile Single submitter ⚠