SDCBP — 28 ClinVar variants
All ClinVar germline SDCBP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
3 Likely benign · 25 Uncertain significance
Full SDCBP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SDCBP p.Ala94Thr Uncertain significance Single submitter
- SDCBP p.Ala94Val Uncertain significance Single submitter
- SDCBP p.Arg113His Uncertain significance Single submitter
- SDCBP p.Arg197Gln Uncertain significance Single submitter
- SDCBP p.Arg197Trp Uncertain significance Single submitter
- SDCBP p.Asp120Glu Uncertain significance Single submitter
- SDCBP p.Asp156Asn Uncertain significance Single submitter
- SDCBP p.Asp224Asn Uncertain significance Single submitter
- SDCBP p.Gln121Arg Uncertain significance Single submitter
- SDCBP p.Gln157Pro Uncertain significance Single submitter
- SDCBP p.Gln180Lys Uncertain significance Single submitter
- SDCBP p.Gly98Ala Uncertain significance Single submitter
- SDCBP p.His236Arg Uncertain significance Single submitter
- SDCBP p.Ile31Thr Uncertain significance Single submitter
- SDCBP p.Ile39Thr Uncertain significance Single submitter
- SDCBP p.Met287Ile Uncertain significance Single submitter
- SDCBP p.Pro26Ala Uncertain significance Single submitter
- SDCBP p.Pro86Ser Uncertain significance Single submitter
- SDCBP p.Ser289Asn Uncertain significance Single submitter
- SDCBP p.Val70Gly Uncertain significance Single submitter
- SDCBP p.Val73Ala Uncertain significance Single submitter
- SDCBP p.Val93Met Uncertain significance Single submitter
- SDCBP p.Val96Leu Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All SDCBP variants
Likely benign 3
- p.Gly43Arg Single submitter
- p.Ile132Val Single submitter
- p.Val72Met Single submitter
Uncertain significance 25
- p.Ala94Thr Single submitter ⚠
- p.Ala94Val Single submitter ⚠
- p.Arg113His Single submitter ⚠
- p.Arg197Gln Single submitter ⚠
- p.Arg197Trp Single submitter ⚠
- p.Arg281Trp Single submitter ⚠
- p.Asp120Glu Single submitter ⚠
- p.Asp156Asn Single submitter ⚠
- p.Asp224Asn Single submitter ⚠
- p.Gln121Arg Single submitter ⚠
- p.Gln142Arg Single submitter ⚠
- p.Gln157Pro Single submitter ⚠
- p.Gln180Lys Single submitter ⚠
- p.Gly98Ala Single submitter ⚠
- p.His236Arg Single submitter ⚠
- p.Ile31Thr Single submitter ⚠
- p.Ile39Thr Single submitter ⚠
- p.Met287Ile Single submitter ⚠
- p.Pro26Ala Single submitter ⚠
- p.Pro86Ser Single submitter ⚠
- p.Ser289Asn Single submitter ⚠
- p.Val70Gly Single submitter ⚠
- p.Val73Ala Single submitter ⚠
- p.Val93Met Single submitter ⚠
- p.Val96Leu Single submitter ⚠