SEC13 — 66 ClinVar variants
All ClinVar germline SEC13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
2 Likely benign · 64 Uncertain significance
Full SEC13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SEC13 p.Ala100Val Uncertain significance Single submitter
- SEC13 p.Ala112Val Uncertain significance Single submitter
- SEC13 p.Ala148Thr Uncertain significance Single submitter
- SEC13 p.Ala161Thr Uncertain significance Single submitter
- SEC13 p.Ala232Thr Uncertain significance Single submitter
- SEC13 p.Arg216Gln Uncertain significance Single submitter
- SEC13 p.Arg239Cys Uncertain significance Single submitter
- SEC13 p.Arg239Pro Uncertain significance Single submitter
- SEC13 p.Arg27His Uncertain significance Single submitter
- SEC13 p.Arg81Trp Uncertain significance Single submitter
- SEC13 p.Asn154Ser Uncertain significance Single submitter
- SEC13 p.Cys299Gly Uncertain significance Single submitter
- SEC13 p.Cys77Ser Uncertain significance Single submitter
- SEC13 p.Gln318Glu Uncertain significance Single submitter
- SEC13 p.Glu198Asp Uncertain significance Single submitter
- SEC13 p.Glu205Gln Uncertain significance Single submitter
- SEC13 p.Gly117Ser Uncertain significance Single submitter
- SEC13 p.Gly138Ser Uncertain significance Single submitter
- SEC13 p.Gly25Ala Uncertain significance Single submitter
- SEC13 p.Gly295Glu Uncertain significance Single submitter
- SEC13 p.Gly71Ser Uncertain significance Single submitter
- SEC13 p.Gly91Ser Uncertain significance Single submitter
- SEC13 p.His211Gln Uncertain significance Single submitter
- SEC13 p.His211Tyr Uncertain significance Single submitter
- SEC13 p.His259Asp Uncertain significance Single submitter
- SEC13 p.Ile179Ser Uncertain significance Single submitter
- SEC13 p.Ile276Val Uncertain significance Single submitter
- SEC13 p.Ile84Val Uncertain significance Single submitter
- SEC13 p.Ile85Thr Uncertain significance Single submitter
- SEC13 p.Leu190Phe Uncertain significance Single submitter
- SEC13 p.Lys180Arg Uncertain significance Single submitter
- SEC13 p.Lys38Arg Uncertain significance Single submitter
- SEC13 p.Pro176His Uncertain significance Single submitter
- SEC13 p.Ser223Ala Uncertain significance Single submitter
- SEC13 p.Ser309Phe Uncertain significance Single submitter
- SEC13 p.Ser78Phe Uncertain significance Single submitter
- SEC13 p.Ser96Arg Uncertain significance Single submitter
- SEC13 p.Ser96Asn Uncertain significance Single submitter
- SEC13 p.Thr230Ser Uncertain significance Single submitter
- SEC13 p.Thr252Met Uncertain significance Single submitter
- SEC13 p.Trp140Arg Uncertain significance Single submitter
- SEC13 p.Tyr178Cys Uncertain significance Single submitter
- SEC13 p.Tyr24Cys Uncertain significance Single submitter
- SEC13 p.Val265Ala Uncertain significance Single submitter
- SEC13 p.Val293Phe Uncertain significance Single submitter
- SEC13 p.Val303Ile Uncertain significance Single submitter
- SEC13 p.Val310Ile Uncertain significance Single submitter
- SEC13 p.Val37Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- SEC13 p.Ala148Gly Uncertain significance Single submitter
- SEC13 p.Ala19Thr Uncertain significance Single submitter
- SEC13 p.Ala66Ser Uncertain significance Single submitter
- SEC13 p.Arg43Cys Uncertain significance Single submitter
- SEC13 p.Arg54Ser Uncertain significance Single submitter
- SEC13 p.Arg81Gln Uncertain significance Single submitter
- SEC13 p.Asn275Lys Uncertain significance Single submitter
- SEC13 p.Asp103Asn Uncertain significance Single submitter
- SEC13 p.Ile119Phe Uncertain significance Single submitter
- SEC13 p.Ile145Met Uncertain significance Single submitter
- SEC13 p.Leu28Val Uncertain significance Single submitter
- SEC13 p.Lys260Asn Uncertain significance Single submitter
- SEC13 p.Phe241Leu Uncertain significance Single submitter
All SEC13 variants
Likely benign 2
- p.Ser309= Single submitter
- p.Ser96Thr Single submitter
Uncertain significance 64
- p.Ala100Val Single submitter ⚠
- p.Ala112Val Single submitter ⚠
- p.Ala148Gly Single submitter ⚠
- p.Ala148Thr Single submitter ⚠
- p.Ala161Thr Single submitter ⚠
- p.Ala183Thr Single submitter
- p.Ala19Thr Single submitter ⚠
- p.Ala232Thr Single submitter ⚠
- p.Ala66Ser Single submitter ⚠
- p.Arg216Gln Single submitter ⚠
- p.Arg239Cys Single submitter ⚠
- p.Arg239Pro Single submitter ⚠
- p.Arg27His Single submitter ⚠
- p.Arg43Cys Single submitter ⚠
- p.Arg54Ser Single submitter ⚠
- p.Arg81Gln Single submitter ⚠
- p.Arg81Trp Single submitter ⚠
- p.Asn154Ser Single submitter ⚠
- p.Asn275Lys Single submitter ⚠
- p.Asp103Asn Single submitter ⚠
- p.Cys299Gly Single submitter ⚠
- p.Cys77Ser Single submitter ⚠
- p.Gln318Glu Single submitter ⚠
- p.Glu198Asp Single submitter ⚠
- p.Glu205Gln Single submitter ⚠
- p.Gly117Ser Single submitter ⚠
- p.Gly138Ser Single submitter ⚠
- p.Gly25Ala Single submitter ⚠
- p.Gly295Glu Single submitter ⚠
- p.Gly71Ser Single submitter ⚠
- p.Gly91Ser Single submitter ⚠
- p.His211Gln Single submitter ⚠
- p.His211Tyr Single submitter ⚠
- p.His259Asp Single submitter ⚠
- p.Ile119Phe Single submitter ⚠
- p.Ile145Met Single submitter ⚠
- p.Ile179Ser Single submitter ⚠
- p.Ile276Val Single submitter ⚠
- p.Ile84Val Single submitter ⚠
- p.Ile85Thr Single submitter ⚠
- p.Leu190Phe Single submitter ⚠
- p.Leu28Val Single submitter ⚠
- p.Leu49Phe Single submitter
- p.Lys180Arg Single submitter ⚠
- p.Lys260Asn Single submitter ⚠
- p.Lys38Arg Single submitter ⚠
- p.Phe182Val Single submitter
- p.Phe241Leu Single submitter ⚠
- p.Pro176His Single submitter ⚠
- p.Ser223Ala Single submitter ⚠
- p.Ser309Phe Single submitter ⚠
- p.Ser78Phe Single submitter ⚠
- p.Ser96Arg Single submitter ⚠
- p.Ser96Asn Single submitter ⚠
- p.Thr230Ser Single submitter ⚠
- p.Thr252Met Single submitter ⚠
- p.Trp140Arg Single submitter ⚠
- p.Tyr178Cys Single submitter ⚠
- p.Tyr24Cys Single submitter ⚠
- p.Val265Ala Single submitter ⚠
- p.Val293Phe Single submitter ⚠
- p.Val303Ile Single submitter ⚠
- p.Val310Ile Single submitter ⚠
- p.Val37Ile Single submitter ⚠