SEC61B — 14 ClinVar variants
All ClinVar germline SEC61B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
4 Benign · 10 Uncertain significance
Full SEC61B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SEC61B p.Ala26Thr Uncertain significance Single submitter
- SEC61B p.Ala44Val Uncertain significance Single submitter
- SEC61B p.Ala82Thr Uncertain significance Single submitter
- SEC61B p.Gly69Val Uncertain significance Single submitter
- SEC61B p.Gly91Cys Uncertain significance Single submitter
- SEC61B p.Pro70Ser Uncertain significance Single submitter
- SEC61B p.Thr5Ala Uncertain significance Single submitter
All SEC61B variants
Benign 4
- c.101+11C>G Multiple submitters
- c.203+61A>G Multiple submitters
- c.102-128A>G Single submitter
- c.102-236A>G Single submitter
Uncertain significance 10
- p.Ala26Thr Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Ala82Thr Single submitter ⚠
- p.Arg57Gln Single submitter
- p.Gly69Val Single submitter ⚠
- p.Gly91Cys Single submitter ⚠
- p.Pro70Ser Single submitter ⚠
- p.Thr5Ala Single submitter ⚠
- p.Asn36fs No assertion criteria
- p.Met1Val No assertion criteria