SELPLG — 72 ClinVar variants
All ClinVar germline SELPLG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
4 Benign · 15 Likely benign · 53 Uncertain significance
Full SELPLG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SELPLG p.Ala107Val Uncertain significance Single submitter
- SELPLG p.Ala147Thr Uncertain significance Single submitter
- SELPLG p.Ala158Pro Uncertain significance Single submitter
- SELPLG p.Ala191Thr Uncertain significance Single submitter
- SELPLG p.Ala271Thr Uncertain significance Single submitter
- SELPLG p.Arg155Pro Uncertain significance Single submitter
- SELPLG p.Arg347Cys Uncertain significance Single submitter
- SELPLG p.Arg355His Uncertain significance Single submitter
- SELPLG p.Asn306Ser Uncertain significance Single submitter
- SELPLG p.Asp115Gly Uncertain significance Single submitter
- SELPLG p.Asp94Asn Uncertain significance Single submitter
- SELPLG p.Gly281Asp Uncertain significance Single submitter
- SELPLG p.Gly375Trp Uncertain significance Single submitter
- SELPLG p.Gly382Arg Uncertain significance Single submitter
- SELPLG p.Gly391Arg Uncertain significance Single submitter
- SELPLG p.Leu12Met Uncertain significance Single submitter
- SELPLG p.Lys386Glu Uncertain significance Single submitter
- SELPLG p.Lys388Asn Uncertain significance Single submitter
- SELPLG p.Met109Lys Uncertain significance Single submitter
- SELPLG p.Met109Val Uncertain significance Single submitter
- SELPLG p.Met229Val Uncertain significance Single submitter
- SELPLG p.Met351Arg Uncertain significance Single submitter
- SELPLG p.Pro145Arg Uncertain significance Single submitter
- SELPLG p.Pro176Ser Uncertain significance Single submitter
- SELPLG p.Pro216Ser Uncertain significance Single submitter
- SELPLG p.Pro370Ser Uncertain significance Single submitter
- SELPLG p.Pro390Leu Uncertain significance Single submitter
- SELPLG p.Pro75Ser Uncertain significance Single submitter
- SELPLG p.Ser389Arg Uncertain significance Single submitter
- SELPLG p.Thr159Met Uncertain significance Single submitter
- SELPLG p.Thr179Met Uncertain significance Single submitter
- SELPLG p.Thr393Met Uncertain significance Single submitter
- SELPLG p.Thr57Met Uncertain significance Single submitter
- SELPLG p.Thr69Asn Uncertain significance Single submitter
- SELPLG p.Thr70Pro Uncertain significance Single submitter
- SELPLG p.Thr82Ser Uncertain significance Single submitter
- SELPLG p.Val291Leu Uncertain significance Single submitter
- SELPLG p.Val317Met Uncertain significance Single submitter
- SELPLG p.Val83Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- SELPLG p.Ala328Val Uncertain significance Single submitter
- SELPLG p.Ala342Val Uncertain significance Single submitter
- SELPLG p.Arg38Trp Uncertain significance Single submitter
- SELPLG p.Gln172Leu Likely benign Single submitter
- SELPLG p.Gln172Pro Uncertain significance Single submitter
- SELPLG p.Gln232Glu Uncertain significance Single submitter
- SELPLG p.Glu361Gln Uncertain significance Single submitter
- SELPLG p.Glu361Gly Uncertain significance Single submitter
- SELPLG p.Leu405Phe Uncertain significance Single submitter
- SELPLG p.Thr104Met Likely benign Single submitter
- SELPLG p.Thr153Ile Uncertain significance Single submitter
- SELPLG p.Thr194Ser Uncertain significance Single submitter
- SELPLG p.Thr227Arg Uncertain significance Single submitter
- SELPLG p.Thr254Ile Uncertain significance Single submitter
- SELPLG p.Thr264Ala Uncertain significance Single submitter
All SELPLG variants
Benign 4
- p.Thr157Met Multiple submitters
- p.Thr239= Multiple submitters
- p.Gln135_Thr144del Single submitter
- p.Met62Ile No assertion criteria SELPLG-related disorder
Likely benign 15
- p.Arg89His Single submitter
- p.Gln172Leu Single submitter ⚠
- p.Glu200= Single submitter
- p.Glu29Lys Single submitter
- p.Met219Thr Single submitter
- p.Ser267Asn Single submitter
- p.Ser289Pro Single submitter
- p.Ser304= Single submitter
- p.Thr104Met Single submitter ⚠
- p.Thr139Met Single submitter
- p.Thr157Ala Single submitter
- p.Asn108= No assertion criteria SELPLG-related disorder
- p.Phe335= No assertion criteria SELPLG-related disorder
- p.Thr44= No assertion criteria SELPLG-related disorder
- p.Val305Ile No assertion criteria SELPLG-related disorder
Uncertain significance 53
- p.Ala107Val Single submitter ⚠
- p.Ala147Thr Single submitter ⚠
- p.Ala158Pro Single submitter ⚠
- p.Ala191Thr Single submitter ⚠
- p.Ala271Thr Single submitter ⚠
- p.Ala328Val Single submitter ⚠
- p.Ala342Val Single submitter ⚠
- p.Arg155Pro Single submitter ⚠
- p.Arg347Cys Single submitter ⚠
- p.Arg355Cys Single submitter
- p.Arg355His Single submitter ⚠
- p.Arg38Trp Single submitter ⚠
- p.Asn306Ser Single submitter ⚠
- p.Asp115Gly Single submitter ⚠
- p.Asp94Asn Single submitter ⚠
- p.Gln172Pro Single submitter ⚠
- p.Gln232Glu Single submitter ⚠
- p.Glu361Gln Single submitter ⚠
- p.Glu361Gly Single submitter ⚠
- p.Gly281Asp Single submitter ⚠
- p.Gly375Trp Single submitter ⚠
- p.Gly382Arg Single submitter ⚠
- p.Gly391Arg Single submitter ⚠
- p.Leu12Met Single submitter ⚠
- p.Leu405Phe Single submitter ⚠
- p.Lys386Glu Single submitter ⚠
- p.Lys388Asn Single submitter ⚠
- p.Met109Lys Single submitter ⚠
- p.Met109Val Single submitter ⚠
- p.Met229Val Single submitter ⚠
- p.Met351Arg Single submitter ⚠
- p.Pro145Arg Single submitter ⚠
- p.Pro176Ser Single submitter ⚠
- p.Pro216Ser Single submitter ⚠
- p.Pro370Ser Single submitter ⚠
- p.Pro390Leu Single submitter ⚠
- p.Pro75Ser Single submitter ⚠
- p.Ser389Arg Single submitter ⚠
- p.Thr153Ile Single submitter ⚠
- p.Thr159Met Single submitter ⚠
- p.Thr179Met Single submitter ⚠
- p.Thr194Ser Single submitter ⚠
- p.Thr227Arg Single submitter ⚠
- p.Thr254Ile Single submitter ⚠
- p.Thr264Ala Single submitter ⚠
- p.Thr393Met Single submitter ⚠
- p.Thr57Met Single submitter ⚠
- p.Thr69Asn Single submitter ⚠
- p.Thr70Pro Single submitter ⚠
- p.Thr82Ser Single submitter ⚠
- p.Val291Leu Single submitter ⚠
- p.Val317Met Single submitter ⚠
- p.Val83Met Single submitter ⚠