SENP2 — 73 ClinVar variants
All ClinVar germline SENP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
2 Benign · 3 Likely benign · 68 Uncertain significance
Full SENP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SENP2 p.Arg139Gln Uncertain significance Single submitter
- SENP2 p.Arg143His Uncertain significance Single submitter
- SENP2 p.Arg165His Uncertain significance Single submitter
- SENP2 p.Arg165Leu Uncertain significance Single submitter
- SENP2 p.Arg166His Uncertain significance Single submitter
- SENP2 p.Arg199His Uncertain significance Single submitter
- SENP2 p.Arg217Gln Uncertain significance Single submitter
- SENP2 p.Arg222Gln Uncertain significance Single submitter
- SENP2 p.Arg244Gly Uncertain significance Single submitter
- SENP2 p.Arg31Leu Uncertain significance Single submitter
- SENP2 p.Arg341Gly Uncertain significance Single submitter
- SENP2 p.Arg360Gly Uncertain significance Single submitter
- SENP2 p.Arg90Trp Uncertain significance Single submitter
- SENP2 p.Asn378Ser Uncertain significance Single submitter
- SENP2 p.Asn462Asp Uncertain significance Single submitter
- SENP2 p.Asn87Tyr Uncertain significance Single submitter
- SENP2 p.Asp363Glu Uncertain significance Single submitter
- SENP2 p.Cys233Tyr Uncertain significance Single submitter
- SENP2 p.Cys283Arg Uncertain significance Single submitter
- SENP2 p.Gln272His Uncertain significance Single submitter
- SENP2 p.Gln499Lys Uncertain significance Single submitter
- SENP2 p.Gln586Arg Uncertain significance Single submitter
- SENP2 p.Glu187Asp Uncertain significance Single submitter
- SENP2 p.Glu318Ala Uncertain significance Single submitter
- SENP2 p.Glu347Gly Uncertain significance Single submitter
- SENP2 p.Gly157Ala Uncertain significance Single submitter
- SENP2 p.Gly227Arg Uncertain significance Single submitter
- SENP2 p.Gly262Arg Uncertain significance Single submitter
- SENP2 p.Gly337Asp Uncertain significance Single submitter
- SENP2 p.Gly337Cys Uncertain significance Single submitter
- SENP2 p.Gly498Glu Uncertain significance Single submitter
- SENP2 p.His201Tyr Uncertain significance Single submitter
- SENP2 p.His537Tyr Uncertain significance Single submitter
- SENP2 p.His57Tyr Uncertain significance Single submitter
- SENP2 p.Ile346Asn Uncertain significance Single submitter
- SENP2 p.Leu107Pro Uncertain significance Single submitter
- SENP2 p.Leu117Val Uncertain significance Single submitter
- SENP2 p.Leu26Phe Uncertain significance Single submitter
- SENP2 p.Leu486Arg Uncertain significance Single submitter
- SENP2 p.Leu63Phe Uncertain significance Single submitter
- SENP2 p.Leu63Val Uncertain significance Single submitter
- SENP2 p.Lys271Glu Uncertain significance Single submitter
- SENP2 p.Lys563Glu Uncertain significance Single submitter
- SENP2 p.Met177Arg Uncertain significance Single submitter
- SENP2 p.Met177Ile Uncertain significance Single submitter
- SENP2 p.Met177Val Uncertain significance Single submitter
- SENP2 p.Met247Thr Uncertain significance Single submitter
- SENP2 p.Phe55Val Uncertain significance Single submitter
- SENP2 p.Pro234Arg Uncertain significance Single submitter
- SENP2 p.Pro281Leu Uncertain significance Single submitter
- SENP2 p.Pro384Leu Uncertain significance Single submitter
- SENP2 p.Pro384Ser Uncertain significance Single submitter
- SENP2 p.Pro573Arg Uncertain significance Single submitter
- SENP2 p.Ser245Asn Uncertain significance Single submitter
- SENP2 p.Ser377Asn Uncertain significance Single submitter
- SENP2 p.Ser390Thr Uncertain significance Single submitter
- SENP2 p.Thr11Ile Uncertain significance Single submitter
- SENP2 p.Thr136Pro Uncertain significance Single submitter
- SENP2 p.Thr299Ile Uncertain significance Single submitter
- SENP2 p.Thr39Ala Uncertain significance Single submitter
- SENP2 p.Thr39Ser Uncertain significance Single submitter
- SENP2 p.Trp255Cys Uncertain significance Single submitter
- SENP2 p.Trp255Leu Uncertain significance Single submitter
- SENP2 p.Val343Leu Uncertain significance Single submitter
- SENP2 p.Val6Gly Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All SENP2 variants
Benign 2
- p.Asn238Asp Multiple submitters
- p.Thr301Lys Multiple submitters
Likely benign 3
- c.818-4A>G Single submitter
- p.Leu285= Single submitter
- p.Thr297Ser Single submitter
Uncertain significance 68
- p.Ala453Thr Single submitter ⚠
- p.Arg139Gln Single submitter ⚠
- p.Arg143His Single submitter ⚠
- p.Arg165His Single submitter ⚠
- p.Arg165Leu Single submitter ⚠
- p.Arg166His Single submitter ⚠
- p.Arg199His Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Arg222Gln Single submitter ⚠
- p.Arg244Gly Single submitter ⚠
- p.Arg31Leu Single submitter ⚠
- p.Arg341Gly Single submitter ⚠
- p.Arg360Gly Single submitter ⚠
- p.Arg90Trp Single submitter ⚠
- p.Asn378Ser Single submitter ⚠
- p.Asn462Asp Single submitter ⚠
- p.Asn87Tyr Single submitter ⚠
- p.Asp363Glu Single submitter ⚠
- p.Cys233Tyr Single submitter ⚠
- p.Cys283Arg Single submitter ⚠
- p.Gln272His Single submitter ⚠
- p.Gln499Lys Single submitter ⚠
- p.Gln586Arg Single submitter ⚠
- p.Glu187Asp Single submitter ⚠
- p.Glu318Ala Single submitter ⚠
- p.Glu347Gly Single submitter ⚠
- p.Gly157Ala Single submitter ⚠
- p.Gly227Arg Single submitter ⚠
- p.Gly262Arg Single submitter ⚠
- p.Gly337Asp Single submitter ⚠
- p.Gly337Cys Single submitter ⚠
- p.Gly498Glu Single submitter ⚠
- p.His201Tyr Single submitter ⚠
- p.His537Tyr Single submitter ⚠
- p.His57Tyr Single submitter ⚠
- p.Ile346Asn Single submitter ⚠
- p.Leu107Pro Single submitter ⚠
- p.Leu117Val Single submitter ⚠
- p.Leu26Phe Single submitter ⚠
- p.Leu486Arg Single submitter ⚠
- p.Leu63Phe Single submitter ⚠
- p.Leu63Val Single submitter ⚠
- p.Lys271Glu Single submitter ⚠
- p.Lys563Glu Single submitter ⚠
- p.Met177Arg Single submitter ⚠
- p.Met177Ile Single submitter ⚠
- p.Met177Val Single submitter ⚠
- p.Met247Thr Single submitter ⚠
- p.Phe55Leu Single submitter ⚠
- p.Phe55Val Single submitter ⚠
- p.Pro234Arg Single submitter ⚠
- p.Pro281Leu Single submitter ⚠
- p.Pro384Leu Single submitter ⚠
- p.Pro384Ser Single submitter ⚠
- p.Pro573Arg Single submitter ⚠
- p.Ser245Asn Single submitter ⚠
- p.Ser377Asn Single submitter ⚠
- p.Ser390Thr Single submitter ⚠
- p.Ser448Phe Single submitter
- p.Thr11Ile Single submitter ⚠
- p.Thr136Pro Single submitter ⚠
- p.Thr299Ile Single submitter ⚠
- p.Thr39Ala Single submitter ⚠
- p.Thr39Ser Single submitter ⚠
- p.Trp255Cys Single submitter ⚠
- p.Trp255Leu Single submitter ⚠
- p.Val343Leu Single submitter ⚠
- p.Val6Gly Single submitter ⚠