SENP5 — 85 ClinVar variants
All ClinVar germline SENP5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
4 Benign · 2 Likely benign · 79 Uncertain significance
Full SENP5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SENP5 p.Ala575Val Uncertain significance Single submitter
- SENP5 p.Arg132Thr Uncertain significance Single submitter
- SENP5 p.Arg156Gly Uncertain significance Single submitter
- SENP5 p.Arg265Gln Uncertain significance Single submitter
- SENP5 p.Arg280Lys Uncertain significance Single submitter
- SENP5 p.Arg302Gly Uncertain significance Single submitter
- SENP5 p.Arg302Trp Uncertain significance Single submitter
- SENP5 p.Arg46Ser Uncertain significance Single submitter
- SENP5 p.Arg528Lys Uncertain significance Single submitter
- SENP5 p.Asn146Ser Uncertain significance Single submitter
- SENP5 p.Asn153His Uncertain significance Single submitter
- SENP5 p.Asn171Ser Uncertain significance Single submitter
- SENP5 p.Asn354Lys Uncertain significance Single submitter
- SENP5 p.Asn709His Uncertain significance Single submitter
- SENP5 p.Asp127Gly Uncertain significance Single submitter
- SENP5 p.Cys326Ser Uncertain significance Single submitter
- SENP5 p.Cys368Gly Uncertain significance Single submitter
- SENP5 p.Gln151Glu Uncertain significance Single submitter
- SENP5 p.Gln264Arg Uncertain significance Single submitter
- SENP5 p.Gln707His Uncertain significance Single submitter
- SENP5 p.Glu133Asp Uncertain significance Single submitter
- SENP5 p.Glu379Gly Uncertain significance Single submitter
- SENP5 p.Glu735Asp Uncertain significance Single submitter
- SENP5 p.Gly198Ser Uncertain significance Single submitter
- SENP5 p.Gly209Ala Uncertain significance Single submitter
- SENP5 p.Gly209Arg Uncertain significance Single submitter
- SENP5 p.Gly27Ser Uncertain significance Single submitter
- SENP5 p.Gly283Ser Uncertain significance Single submitter
- SENP5 p.Gly398Asp Uncertain significance Single submitter
- SENP5 p.His103Arg Uncertain significance Single submitter
- SENP5 p.His14Pro Uncertain significance Single submitter
- SENP5 p.His222Tyr Uncertain significance Single submitter
- SENP5 p.His36Tyr Uncertain significance Single submitter
- SENP5 p.His380Tyr Uncertain significance Single submitter
- SENP5 p.Leu112Arg Uncertain significance Single submitter
- SENP5 p.Leu119Pro Uncertain significance Single submitter
- SENP5 p.Leu631Val Uncertain significance Single submitter
- SENP5 p.Lys256Asn Uncertain significance Single submitter
- SENP5 p.Lys262Arg Uncertain significance Single submitter
- SENP5 p.Lys270Glu Uncertain significance Single submitter
- SENP5 p.Lys297Glu Uncertain significance Single submitter
- SENP5 p.Lys329Gln Uncertain significance Single submitter
- SENP5 p.Lys336Arg Uncertain significance Single submitter
- SENP5 p.Lys432Asn Uncertain significance Single submitter
- SENP5 p.Lys68Glu Uncertain significance Single submitter
- SENP5 p.Lys708Arg Uncertain significance Single submitter
- SENP5 p.Lys742Arg Uncertain significance Single submitter
- SENP5 p.Lys95Thr Uncertain significance Single submitter
- SENP5 p.Met168Leu Uncertain significance Single submitter
- SENP5 p.Met385Val Uncertain significance Single submitter
- SENP5 p.Phe217Ser Uncertain significance Single submitter
- SENP5 p.Pro144Gln Uncertain significance Single submitter
- SENP5 p.Pro161Leu Uncertain significance Single submitter
- SENP5 p.Pro324Ala Uncertain significance Single submitter
- SENP5 p.Pro378Ser Uncertain significance Single submitter
- SENP5 p.Pro461Ala Uncertain significance Single submitter
- SENP5 p.Pro75Leu Uncertain significance Single submitter
- SENP5 p.Ser121Leu Uncertain significance Single submitter
- SENP5 p.Ser300Ala Uncertain significance Single submitter
- SENP5 p.Ser312Asn Uncertain significance Single submitter
- SENP5 p.Ser321Phe Uncertain significance Single submitter
- SENP5 p.Ser331Asn Uncertain significance Single submitter
- SENP5 p.Ser362Cys Uncertain significance Single submitter
- SENP5 p.Ser388Leu Uncertain significance Single submitter
- SENP5 p.Ser439Leu Uncertain significance Single submitter
- SENP5 p.Ser655Pro Uncertain significance Single submitter
- SENP5 p.Thr272Ala Uncertain significance Single submitter
- SENP5 p.Thr403Ser Uncertain significance Single submitter
- SENP5 p.Thr69Met Uncertain significance Single submitter
- SENP5 p.Trp70Ser Uncertain significance Single submitter
- SENP5 p.Val422Gly Uncertain significance Single submitter
- SENP5 p.Val422Met Uncertain significance Single submitter
- SENP5 p.Val434Ile Uncertain significance Single submitter
- SENP5 p.Val673Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All SENP5 variants
Benign 4
- p.Asn83Ser Multiple submitters
- p.Gly350Asp Multiple submitters
- p.Pro47= Multiple submitters
- c.2158-8T>C Single submitter
Likely benign 2
- p.Ala101Thr Single submitter
- p.Gln221Arg Single submitter
Uncertain significance 79
- p.Ala575Val Single submitter ⚠
- p.Arg132Thr Single submitter ⚠
- p.Arg156Gly Single submitter ⚠
- p.Arg265Gln Single submitter ⚠
- p.Arg280Lys Single submitter ⚠
- p.Arg302Gly Single submitter ⚠
- p.Arg302Trp Single submitter ⚠
- p.Arg46Ser Single submitter ⚠
- p.Arg528Lys Single submitter ⚠
- p.Asn146Ser Single submitter ⚠
- p.Asn153His Single submitter ⚠
- p.Asn171Ser Single submitter ⚠
- p.Asn354Lys Single submitter ⚠
- p.Asn709His Single submitter ⚠
- p.Asp127Gly Single submitter ⚠
- p.Cys326Ser Single submitter ⚠
- p.Cys368Gly Single submitter ⚠
- p.Gln151Glu Single submitter ⚠
- p.Gln264Arg Single submitter ⚠
- p.Gln707His Single submitter ⚠
- p.Glu133Asp Single submitter ⚠
- p.Glu379Gly Single submitter ⚠
- p.Glu735Asp Single submitter ⚠
- p.Gly198Ser Single submitter ⚠
- p.Gly209Ala Single submitter ⚠
- p.Gly209Arg Single submitter ⚠
- p.Gly27Ser Single submitter ⚠
- p.Gly283Ser Single submitter ⚠
- p.Gly398Asp Single submitter ⚠
- p.His103Arg Single submitter ⚠
- p.His14Pro Single submitter ⚠
- p.His222Tyr Single submitter ⚠
- p.His36Tyr Single submitter ⚠
- p.His380Tyr Single submitter ⚠
- p.Ile595Leu Single submitter ⚠
- p.Leu112Arg Single submitter ⚠
- p.Leu119Pro Single submitter ⚠
- p.Leu227Ter Single submitter
- p.Leu631Val Single submitter ⚠
- p.Lys256Asn Single submitter ⚠
- p.Lys262Arg Single submitter ⚠
- p.Lys270Glu Single submitter ⚠
- p.Lys297Glu Single submitter ⚠
- p.Lys329Gln Single submitter ⚠
- p.Lys336Arg Single submitter ⚠
- p.Lys432Asn Single submitter ⚠
- p.Lys68Glu Single submitter ⚠
- p.Lys708Arg Single submitter ⚠
- p.Lys742Arg Single submitter ⚠
- p.Lys95Thr Single submitter ⚠
- p.Met168Leu Single submitter ⚠
- p.Met385Val Single submitter ⚠
- p.Phe217Ser Single submitter ⚠
- p.Pro144Gln Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro324Ala Single submitter ⚠
- p.Pro378Ser Single submitter ⚠
- p.Pro461Ala Single submitter ⚠
- p.Pro690Arg Single submitter ⚠
- p.Pro75Leu Single submitter ⚠
- p.Ser121Leu Single submitter ⚠
- p.Ser300Ala Single submitter ⚠
- p.Ser312Asn Single submitter ⚠
- p.Ser321Phe Single submitter ⚠
- p.Ser331Asn Single submitter ⚠
- p.Ser362Cys Single submitter ⚠
- p.Ser388Leu Single submitter ⚠
- p.Ser439Leu Single submitter ⚠
- p.Ser648Ala Single submitter ⚠
- p.Ser655Pro Single submitter ⚠
- p.Thr272Ala Single submitter ⚠
- p.Thr403Ser Single submitter ⚠
- p.Thr616Ile Single submitter ⚠
- p.Thr69Met Single submitter ⚠
- p.Trp70Ser Single submitter ⚠
- p.Val422Gly Single submitter ⚠
- p.Val422Met Single submitter ⚠
- p.Val434Ile Single submitter ⚠
- p.Val673Ile Single submitter ⚠