SENP6 — 144 ClinVar variants

All ClinVar germline SENP6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 128 flagged for review →

3 Benign · 9 Likely benign · 132 Uncertain significance

Full SENP6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 128

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 113

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 15

The independent predictors disagree with each other — read with care.

All SENP6 variants

Benign 3

c.1959-4A>T Single submitter
p.Arg179= Single submitter
p.Thr254= Single submitter

Likely benign 9

p.Arg157Gln Single submitter
p.Arg157Ter Single submitter Synophrys
p.Arg383His Single submitter
p.Arg73Gln Single submitter
p.Asn578Ser Single submitter
p.Asp478Glu Single submitter
p.Gln624= Single submitter
p.His141Asn Single submitter
p.Val656= Single submitter

Uncertain significance 132

c.1426+1G>A Single submitter
p.Ala10Val Single submitter ⚠
p.Ala433Thr Single submitter ⚠
p.Ala433Val Single submitter ⚠
p.Ala581Val Single submitter ⚠
p.Ala868Val Single submitter ⚠
p.Arg1072Gln Single submitter ⚠
p.Arg179Trp Single submitter ⚠
p.Arg185Cys Single submitter ⚠
p.Arg386Gln Single submitter ⚠
p.Arg457Gly Single submitter
p.Arg500Gln Single submitter ⚠
p.Arg717His Single submitter ⚠
p.Arg724Lys Single submitter ⚠
p.Arg849His Single submitter ⚠
p.Arg887Thr Single submitter ⚠
p.Arg91Gly Single submitter ⚠
p.Arg980Gln Single submitter ⚠
p.Asn1108Ser Single submitter ⚠
p.Asn1108Thr Single submitter ⚠
p.Asn113Ser Single submitter ⚠
p.Asn114Ser Single submitter ⚠
p.Asn329Ser Single submitter ⚠
p.Asn33Ser Single submitter ⚠
p.Asn33Tyr Single submitter ⚠
p.Asn524Lys Single submitter ⚠
p.Asn531Ser Single submitter ⚠
p.Asn817Asp Single submitter ⚠
p.Asp1112Gly Single submitter ⚠
p.Asp430Val Single submitter ⚠
p.Asp475Asn Single submitter ⚠
p.Asp475Tyr Single submitter ⚠
p.Asp480Tyr Single submitter ⚠
p.Asp480Val Single submitter ⚠
p.Asp490His Single submitter ⚠
p.Asp801Asn Single submitter ⚠
p.Cys238Ser Single submitter ⚠
p.Cys360Arg Single submitter ⚠
p.Cys595Ser Single submitter ⚠
p.Cys814Ser Single submitter ⚠
p.Cys833Tyr Single submitter ⚠
p.Gln181Pro Single submitter ⚠
p.Gln215Glu Single submitter ⚠
p.Gln520Pro Single submitter ⚠
p.Gln545Arg Single submitter ⚠
p.Gln734Arg Single submitter ⚠
p.Gln895Arg Single submitter ⚠
p.Glu1101Lys Single submitter ⚠
p.Glu159Lys Single submitter ⚠
p.Glu349Gln Single submitter ⚠
p.Glu611Asp Single submitter ⚠
p.Glu652Asp Single submitter ⚠
p.Glu897Gln Single submitter ⚠
p.Gly103fs Single submitter
p.Gly261Arg Single submitter ⚠
p.Gly309Ala Single submitter ⚠
p.Gly453Arg Single submitter ⚠
p.Gly4Ala Single submitter ⚠
p.Gly590Asp Single submitter ⚠
p.Gly590Val Single submitter ⚠
p.Gly605Arg Single submitter ⚠
p.Gly664Arg Single submitter ⚠
p.Gly959Ala Single submitter ⚠
p.His166Tyr Single submitter ⚠
p.His230Arg Single submitter ⚠
p.His38Arg Single submitter ⚠
p.His674Arg Single submitter ⚠
p.His708Asn Single submitter ⚠
p.His726Tyr Single submitter ⚠
p.Ile1046Met Single submitter ⚠
p.Ile1046Val Single submitter ⚠
p.Ile106Val Single submitter ⚠
p.Ile450Met Single submitter ⚠
p.Ile460Val Single submitter ⚠
p.Ile464Thr Single submitter ⚠
p.Ile464Val Single submitter ⚠
p.Ile510Val Single submitter ⚠
p.Ile547Met Single submitter ⚠
p.Ile547Val Single submitter ⚠
p.Ile550Ser Single submitter ⚠
p.Ile570Leu Single submitter ⚠
p.Ile76Val Single submitter ⚠
p.Ile854Met Single submitter ⚠
p.Ile967Val Single submitter ⚠
p.Leu16Val Single submitter ⚠
p.Leu307Ser Single submitter ⚠
p.Leu625Arg Single submitter ⚠
p.Leu979Phe Single submitter ⚠
p.Lys1006Thr Single submitter ⚠
p.Lys369Arg Single submitter ⚠
p.Lys48Gln Single submitter ⚠
p.Lys795Glu Single submitter ⚠
p.Lys876Glu Single submitter ⚠
p.Lys889Glu Single submitter ⚠
p.Met1053Val Single submitter ⚠
p.Met110Ile Single submitter ⚠
p.Met187Leu Single submitter ⚠
p.Pro1062Leu Single submitter ⚠
p.Pro145Arg Single submitter ⚠
p.Pro164Leu Single submitter ⚠
p.Pro174Leu Single submitter ⚠
p.Pro462Arg Single submitter ⚠
p.Pro584Arg Single submitter ⚠
p.Pro584Ser Single submitter ⚠
p.Pro779Ala Single submitter ⚠
p.Pro841His Single submitter ⚠
p.Pro848Arg Single submitter ⚠
p.Pro965Thr Single submitter ⚠
p.Ser1109Gly Single submitter ⚠
p.Ser193Phe Single submitter ⚠
p.Ser260Phe Single submitter ⚠
p.Ser336Gly Single submitter ⚠
p.Ser42Thr Single submitter ⚠
p.Ser442Gly Single submitter ⚠
p.Ser618Ter Single submitter
p.Ser813Arg Single submitter ⚠
p.Ser818Pro Single submitter ⚠
p.Ser856Arg Single submitter ⚠
p.Ser879Cys Single submitter ⚠
p.Ser944Gly Single submitter ⚠
p.Ser9Ile Single submitter ⚠
p.Ser9Thr Single submitter ⚠
p.Thr213Ala Single submitter ⚠
p.Thr268Lys Single submitter ⚠
p.Thr488Asn Single submitter ⚠
p.Thr729Pro Single submitter ⚠
p.Tyr214Cys Single submitter ⚠
p.Tyr781Cys Single submitter ⚠
p.Val197Glu Single submitter ⚠
p.Val562Gly Single submitter ⚠
p.Val748Ile Single submitter ⚠
p.Val823Leu Single submitter ⚠