SERBP1 — 56 ClinVar variants
All ClinVar germline SERBP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
56 Uncertain significance
Full SERBP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SERBP1 c.696-10A>G Uncertain significance Single submitter
- SERBP1 c.696-23A>G Uncertain significance Single submitter
- SERBP1 c.696-8A>G Uncertain significance Single submitter
- SERBP1 p.Ala318Val Uncertain significance Single submitter
- SERBP1 p.Ala55Gly Uncertain significance Single submitter
- SERBP1 p.Arg175His Uncertain significance Single submitter
- SERBP1 p.Arg349Cys Uncertain significance Single submitter
- SERBP1 p.Arg369His Uncertain significance Single submitter
- SERBP1 p.Asn36Lys Uncertain significance Single submitter
- SERBP1 p.Asn36Ser Uncertain significance Single submitter
- SERBP1 p.Asn62Asp Uncertain significance Single submitter
- SERBP1 p.Asn62Thr Uncertain significance Single submitter
- SERBP1 p.Asp374Asn Uncertain significance Single submitter
- SERBP1 p.Asp374Gly Uncertain significance Single submitter
- SERBP1 p.Gln118His Uncertain significance Single submitter
- SERBP1 p.Glu241Asp Uncertain significance Single submitter
- SERBP1 p.Glu263Asp Uncertain significance Single submitter
- SERBP1 p.Gly149Val Uncertain significance Single submitter
- SERBP1 p.Gly370Val Uncertain significance Single submitter
- SERBP1 p.His249Asp Uncertain significance Single submitter
- SERBP1 p.Ile157Leu Uncertain significance Single submitter
- SERBP1 p.Ile281Leu Uncertain significance Single submitter
- SERBP1 p.Lys68Arg Uncertain significance Single submitter
- SERBP1 p.Lys72Arg Uncertain significance Single submitter
- SERBP1 p.Lys92Gln Uncertain significance Single submitter
- SERBP1 p.Pro128Leu Uncertain significance Single submitter
- SERBP1 p.Pro132Thr Uncertain significance Single submitter
- SERBP1 p.Pro244His Uncertain significance Single submitter
- SERBP1 p.Pro83Ser Uncertain significance Single submitter
- SERBP1 p.Pro83Thr Uncertain significance Single submitter
- SERBP1 p.Pro97Leu Uncertain significance Single submitter
- SERBP1 p.Ser237Leu Uncertain significance Single submitter
- SERBP1 p.Ser25Leu Uncertain significance Single submitter
- SERBP1 p.Ser85Ile Uncertain significance Single submitter
- SERBP1 p.Thr255Asn Uncertain significance Single submitter
- SERBP1 p.Thr95Met Uncertain significance Single submitter
- SERBP1 p.Val227Ile Uncertain significance Single submitter
- SERBP1 p.Val252Leu Uncertain significance Single submitter
- SERBP1 p.Val265Ile Uncertain significance Single submitter
- SERBP1 p.Val324Ile Uncertain significance Single submitter
- SERBP1 p.Val46Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- SERBP1 p.Arg131Gln Uncertain significance Single submitter
- SERBP1 p.Arg165His Uncertain significance Single submitter
- SERBP1 p.Arg181Leu Uncertain significance Single submitter
- SERBP1 p.Arg216His Uncertain significance Single submitter
- SERBP1 p.Arg78Gly Uncertain significance Single submitter
- SERBP1 p.Asn343Ser Uncertain significance Single submitter
- SERBP1 p.Asp18His Uncertain significance Single submitter
- SERBP1 p.Glu259Lys Uncertain significance Single submitter
- SERBP1 p.Gly171Ser Uncertain significance Single submitter
- SERBP1 p.Pro2Ser Uncertain significance Single submitter
- SERBP1 p.Val109Ala Uncertain significance Single submitter
All SERBP1 variants
Uncertain significance 56
- c.606-2A>G Single submitter
- c.696-10A>G Single submitter ⚠
- c.696-23A>G Single submitter ⚠
- c.696-45_696-42del Single submitter
- c.696-8A>G Single submitter ⚠
- p.Ala318Val Single submitter ⚠
- p.Ala55Gly Single submitter ⚠
- p.Arg131Gln Single submitter ⚠
- p.Arg165His Single submitter ⚠
- p.Arg175His Single submitter ⚠
- p.Arg181Leu Single submitter ⚠
- p.Arg216His Single submitter ⚠
- p.Arg349Cys Single submitter ⚠
- p.Arg369His Single submitter ⚠
- p.Arg78Gly Single submitter ⚠
- p.Asn343Ser Single submitter ⚠
- p.Asn36Lys Single submitter ⚠
- p.Asn36Ser Single submitter ⚠
- p.Asn62Asp Single submitter ⚠
- p.Asn62Thr Single submitter ⚠
- p.Asp18His Single submitter ⚠
- p.Asp374Asn Single submitter ⚠
- p.Asp374Gly Single submitter ⚠
- p.Gln118His Single submitter ⚠
- p.Glu241Asp Single submitter ⚠
- p.Glu259Lys Single submitter ⚠
- p.Glu263Asp Single submitter ⚠
- p.Gly149Val Single submitter ⚠
- p.Gly171Ser Single submitter ⚠
- p.Gly370Val Single submitter ⚠
- p.His249Asp Single submitter ⚠
- p.Ile157Leu Single submitter ⚠
- p.Ile281Leu Single submitter ⚠
- p.Lys190Arg Single submitter
- p.Lys68Arg Single submitter ⚠
- p.Lys72Arg Single submitter ⚠
- p.Lys92Gln Single submitter ⚠
- p.Pro128Leu Single submitter ⚠
- p.Pro132Thr Single submitter ⚠
- p.Pro156Leu Single submitter
- p.Pro244His Single submitter ⚠
- p.Pro2Ser Single submitter ⚠
- p.Pro83Ser Single submitter ⚠
- p.Pro83Thr Single submitter ⚠
- p.Pro97Leu Single submitter ⚠
- p.Ser237Leu Single submitter ⚠
- p.Ser25Leu Single submitter ⚠
- p.Ser85Ile Single submitter ⚠
- p.Thr255Asn Single submitter ⚠
- p.Thr95Met Single submitter ⚠
- p.Val109Ala Single submitter ⚠
- p.Val227Ile Single submitter ⚠
- p.Val252Leu Single submitter ⚠
- p.Val265Ile Single submitter ⚠
- p.Val324Ile Single submitter ⚠
- p.Val46Ile Single submitter ⚠