SERPINE3 — 44 ClinVar variants
All ClinVar germline SERPINE3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
7 Likely benign · 37 Uncertain significance
Full SERPINE3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SERPINE3 p.Ala255Ser Uncertain significance Single submitter
- SERPINE3 p.Ala34Ser Uncertain significance Single submitter
- SERPINE3 p.Ala377Val Uncertain significance Single submitter
- SERPINE3 p.Ala43Thr Uncertain significance Single submitter
- SERPINE3 p.Ala68Thr Uncertain significance Single submitter
- SERPINE3 p.Arg23Cys Uncertain significance Single submitter
- SERPINE3 p.Arg371Gln Uncertain significance Single submitter
- SERPINE3 p.Arg379Gln Uncertain significance Single submitter
- SERPINE3 p.Asp265Glu Uncertain significance Single submitter
- SERPINE3 p.Cys214Arg Uncertain significance Single submitter
- SERPINE3 p.Glu156Lys Uncertain significance Single submitter
- SERPINE3 p.Gly165Arg Uncertain significance Single submitter
- SERPINE3 p.Lys30Arg Uncertain significance Single submitter
- SERPINE3 p.Met224Arg Uncertain significance Single submitter
- SERPINE3 p.Met26Ile Uncertain significance Single submitter
- SERPINE3 p.Pro175Leu Uncertain significance Single submitter
- SERPINE3 p.Ser311Asn Uncertain significance Single submitter
- SERPINE3 p.Thr121Met Uncertain significance Single submitter
- SERPINE3 p.Thr154Asn Uncertain significance Single submitter
- SERPINE3 p.Thr319Ser Uncertain significance Single submitter
- SERPINE3 p.Thr356Ala Uncertain significance Single submitter
- SERPINE3 p.Thr83Ser Uncertain significance Single submitter
- SERPINE3 p.Val131Ile Uncertain significance Single submitter
- SERPINE3 p.Val189Leu Uncertain significance Single submitter
- SERPINE3 p.Val222Leu Uncertain significance Single submitter
- SERPINE3 p.Val296Ala Uncertain significance Single submitter
- SERPINE3 p.Val89Leu Uncertain significance Single submitter
- SERPINE3 p.Val96Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All SERPINE3 variants
Likely benign 7
- p.Arg290Lys Single submitter
- p.Glu108Lys Single submitter
- p.Leu352Ser Single submitter
- p.Phe259Leu Single submitter ⚠
- p.Pro2Leu Single submitter
- p.Thr228Met Single submitter
- p.Thr268Ile Single submitter
Uncertain significance 37
- p.Ala255Ser Single submitter ⚠
- p.Ala34Ser Single submitter ⚠
- p.Ala377Val Single submitter ⚠
- p.Ala43Thr Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Arg23Cys Single submitter ⚠
- p.Arg369Thr Single submitter
- p.Arg371Gln Single submitter ⚠
- p.Arg379Gln Single submitter ⚠
- p.Asp265Glu Single submitter ⚠
- p.Cys214Arg Single submitter ⚠
- p.Glu156Lys Single submitter ⚠
- p.Glu274Lys Single submitter
- p.Gly165Arg Single submitter ⚠
- p.Gly317Arg Single submitter
- p.Leu37Phe Single submitter ⚠
- p.Leu61Val Single submitter ⚠
- p.Leu93Ser Single submitter
- p.Lys30Arg Single submitter ⚠
- p.Met224Arg Single submitter ⚠
- p.Met26Ile Single submitter ⚠
- p.Pro175Leu Single submitter ⚠
- p.Pro324Leu Single submitter ⚠
- p.Ser311Asn Single submitter ⚠
- p.Thr121Met Single submitter ⚠
- p.Thr154Asn Single submitter ⚠
- p.Thr319Ser Single submitter ⚠
- p.Thr356Ala Single submitter ⚠
- p.Thr83Ser Single submitter ⚠
- p.Tyr97Asp Single submitter
- p.Val131Ile Single submitter ⚠
- p.Val189Leu Single submitter ⚠
- p.Val222Leu Single submitter ⚠
- p.Val246Met Single submitter ⚠
- p.Val296Ala Single submitter ⚠
- p.Val89Leu Single submitter ⚠
- p.Val96Leu Single submitter ⚠