SF3A2 — 7 ClinVar variants
All ClinVar germline SF3A2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
7 Uncertain significance
Full SF3A2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All SF3A2 variants
Uncertain significance 7
- p.Ala98Thr Single submitter ⚠
- p.Arg6His Single submitter ⚠
- p.Asp25Asn Single submitter ⚠
- p.Glu21Lys Single submitter ⚠
- p.Ile38Val Single submitter ⚠
- p.Thr73Met Single submitter ⚠
- p.Val16Met Single submitter ⚠