SF3B3 — 67 ClinVar variants
All ClinVar germline SF3B3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
67 Uncertain significance
Full SF3B3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SF3B3 p.Ala458Ser Uncertain significance Single submitter
- SF3B3 p.Ala810Ser Uncertain significance Single submitter
- SF3B3 p.Arg1016His Uncertain significance Single submitter
- SF3B3 p.Arg1149Gln Uncertain significance Single submitter
- SF3B3 p.Arg603His Uncertain significance Single submitter
- SF3B3 p.Arg690Cys Uncertain significance Single submitter
- SF3B3 p.Arg697Cys Uncertain significance Single submitter
- SF3B3 p.Asn1083Ser Uncertain significance Single submitter
- SF3B3 p.Asn194Ser Uncertain significance Single submitter
- SF3B3 p.Asn594Ser Uncertain significance Single submitter
- SF3B3 p.Asn859Ser Uncertain significance Single submitter
- SF3B3 p.Asn988Ser Uncertain significance Single submitter
- SF3B3 p.Asp367Tyr Uncertain significance Single submitter
- SF3B3 p.Gln119Arg Uncertain significance Single submitter
- SF3B3 p.Gln782Arg Uncertain significance Single submitter
- SF3B3 p.Glu710Asp Uncertain significance Single submitter
- SF3B3 p.Gly658Ser Uncertain significance Single submitter
- SF3B3 p.Gly744Val Uncertain significance Single submitter
- SF3B3 p.Ile1010Met Uncertain significance Single submitter
- SF3B3 p.Ile256Asn Uncertain significance Single submitter
- SF3B3 p.Ile256Ser Uncertain significance Single submitter
- SF3B3 p.Ile256Val Uncertain significance Single submitter
- SF3B3 p.Ile466Thr Uncertain significance Single submitter
- SF3B3 p.Ile78Val Uncertain significance Single submitter
- SF3B3 p.Ile798Val Uncertain significance Single submitter
- SF3B3 p.Ile872Val Uncertain significance Single submitter
- SF3B3 p.Ile986Val Uncertain significance Single submitter
- SF3B3 p.Phe348Leu Uncertain significance Single submitter
- SF3B3 p.Pro421Thr Uncertain significance Single submitter
- SF3B3 p.Pro597Ala Uncertain significance Single submitter
- SF3B3 p.Ser1103Cys Uncertain significance Single submitter
- SF3B3 p.Ser64Ala Uncertain significance Single submitter
- SF3B3 p.Thr204Ile Uncertain significance Single submitter
- SF3B3 p.Thr738Ala Uncertain significance Single submitter
- SF3B3 p.Thr943Ser Uncertain significance Single submitter
- SF3B3 p.Val116Ala Uncertain significance Single submitter
- SF3B3 p.Val288Ile Uncertain significance Single submitter
- SF3B3 p.Val335Ile Uncertain significance Single submitter
- SF3B3 p.Val587Ala Uncertain significance Single submitter
- SF3B3 p.Val777Leu Uncertain significance Single submitter
- SF3B3 p.Val868Leu Uncertain significance Single submitter
- SF3B3 p.Val925Ile Uncertain significance Single submitter
- SF3B3 p.Val931Gly Uncertain significance Single submitter
-
SF3B3 p.Gly501Trp
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 16
The independent predictors disagree with each other — read with care.
- SF3B3 p.Ala606Gly Uncertain significance Single submitter
- SF3B3 p.Arg463Cys Uncertain significance Single submitter
- SF3B3 p.Arg718His Uncertain significance Single submitter
- SF3B3 p.Arg918Gln Uncertain significance Single submitter
- SF3B3 p.Asn796Lys Uncertain significance Single submitter
- SF3B3 p.Leu1129Val Uncertain significance Single submitter
- SF3B3 p.Leu40Val Uncertain significance Single submitter
- SF3B3 p.Leu713Phe Uncertain significance Single submitter
- SF3B3 p.Lys974Arg Uncertain significance Single submitter
- SF3B3 p.Met298Thr Uncertain significance Single submitter
- SF3B3 p.Met715Ile Uncertain significance Single submitter
- SF3B3 p.Pro1059Ser Uncertain significance Single submitter
- SF3B3 p.Pro954Ser Uncertain significance Single submitter
- SF3B3 p.Ser95Phe Uncertain significance Single submitter
- SF3B3 p.Thr808Pro Uncertain significance Single submitter
- SF3B3 p.Thr811Met Uncertain significance Single submitter
All SF3B3 variants
Uncertain significance 67
- p.Ala458Ser Single submitter ⚠
- p.Ala606Gly Single submitter ⚠
- p.Ala810Ser Single submitter ⚠
- p.Ala910fs Single submitter
- p.Arg1016His Single submitter ⚠
- p.Arg1149Gln Single submitter ⚠
- p.Arg463Cys Single submitter ⚠
- p.Arg464Ter Single submitter
- p.Arg603His Single submitter ⚠
- p.Arg690Cys Single submitter ⚠
- p.Arg697Cys Single submitter ⚠
- p.Arg718His Single submitter ⚠
- p.Arg918Gln Single submitter ⚠
- p.Asn1083Ser Single submitter ⚠
- p.Asn194Ser Single submitter ⚠
- p.Asn594Ser Single submitter ⚠
- p.Asn796Lys Single submitter ⚠
- p.Asn859Ser Single submitter ⚠
- p.Asn988Ser Single submitter ⚠
- p.Asp367Tyr Single submitter ⚠
- p.Gln119Arg Single submitter ⚠
- p.Gln782Arg Single submitter ⚠
- p.Glu400Val Single submitter
- p.Glu710Asp Single submitter ⚠
- p.Gly658Ser Single submitter ⚠
- p.Gly744Val Single submitter ⚠
- p.Ile1010Met Single submitter ⚠
- p.Ile256Asn Single submitter ⚠
- p.Ile256Ser Single submitter ⚠
- p.Ile256Val Single submitter ⚠
- p.Ile466Thr Single submitter ⚠
- p.Ile78Val Single submitter ⚠
- p.Ile798Val Single submitter ⚠
- p.Ile872Val Single submitter ⚠
- p.Ile986Val Single submitter ⚠
- p.Leu1129Val Single submitter ⚠
- p.Leu40Val Single submitter ⚠
- p.Leu713Phe Single submitter ⚠
- p.Lys974Arg Single submitter ⚠
- p.Met298Thr Single submitter ⚠
- p.Met715Ile Single submitter ⚠
- p.Phe348Leu Single submitter ⚠
- p.Pro1059Ser Single submitter ⚠
- p.Pro421Thr Single submitter ⚠
- p.Pro597Ala Single submitter ⚠
- p.Pro848Thr Single submitter
- p.Pro954Ser Single submitter ⚠
- p.Ser1103Cys Single submitter ⚠
- p.Ser64Ala Single submitter ⚠
- p.Ser95Phe Single submitter ⚠
- p.Thr204Ile Single submitter ⚠
- p.Thr738Ala Single submitter ⚠
- p.Thr802Met Single submitter
- p.Thr808Pro Single submitter ⚠
- p.Thr811Met Single submitter ⚠
- p.Thr943Ser Single submitter ⚠
- p.Tyr1041Cys Single submitter
- p.Val116Ala Single submitter ⚠
- p.Val288Ile Single submitter ⚠
- p.Val335Ile Single submitter ⚠
- p.Val587Ala Single submitter ⚠
- p.Val588Leu Single submitter
- p.Val777Leu Single submitter ⚠
- p.Val868Leu Single submitter ⚠
- p.Val925Ile Single submitter ⚠
- p.Val931Gly Single submitter ⚠
- p.Gly501Trp No assertion criteria prostate cancer ⚠