SFRP1 — 30 ClinVar variants
All ClinVar germline SFRP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
2 Benign · 1 Likely benign · 27 Uncertain significance
Full SFRP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SFRP1 p.Ala168Ser Uncertain significance Single submitter
- SFRP1 p.Ala174Thr Uncertain significance Single submitter
- SFRP1 p.Ala254Thr Uncertain significance Single submitter
- SFRP1 p.Arg50His Uncertain significance Single submitter
- SFRP1 p.Arg50Pro Uncertain significance Single submitter
- SFRP1 p.Gln110His Uncertain significance Single submitter
- SFRP1 p.Gly2Val Uncertain significance Single submitter
- SFRP1 p.Gly9Val Uncertain significance Single submitter
- SFRP1 p.Ile167Met Uncertain significance Single submitter
- SFRP1 p.Ile199Val Uncertain significance Single submitter
- SFRP1 p.Leu233Val Uncertain significance Single submitter
- SFRP1 p.Lys286Arg Uncertain significance Single submitter
- SFRP1 p.Pro232Ala Uncertain significance Single submitter
- SFRP1 p.Pro45Arg Uncertain significance Single submitter
- SFRP1 p.Ser311Pro Uncertain significance Single submitter
- SFRP1 p.Ser38Asn Uncertain significance Single submitter
- SFRP1 p.Thr184Met Uncertain significance Single submitter
- SFRP1 p.Tyr46His Uncertain significance Single submitter
- SFRP1 p.Val312Met Uncertain significance Single submitter
- SFRP1 p.Val59Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- SFRP1 p.Asp60Val Uncertain significance Single submitter
- SFRP1 p.Glu141Gly Uncertain significance Single submitter
- SFRP1 p.His201Gln Uncertain significance Single submitter
- SFRP1 p.Lys231Thr Uncertain significance Single submitter
- SFRP1 p.Met271Ile Uncertain significance Single submitter
- SFRP1 p.Met271Val Uncertain significance Single submitter
- SFRP1 p.Tyr150Cys Uncertain significance Single submitter
All SFRP1 variants
Likely benign 1
- p.Ala63Val Single submitter
Uncertain significance 27
- p.Ala168Ser Single submitter ⚠
- p.Ala174Thr Single submitter ⚠
- p.Ala254Thr Single submitter ⚠
- p.Arg50His Single submitter ⚠
- p.Arg50Pro Single submitter ⚠
- p.Asp60Val Single submitter ⚠
- p.Gln110His Single submitter ⚠
- p.Glu141Gly Single submitter ⚠
- p.Gly2Val Single submitter ⚠
- p.Gly9Val Single submitter ⚠
- p.His201Gln Single submitter ⚠
- p.Ile167Met Single submitter ⚠
- p.Ile199Val Single submitter ⚠
- p.Leu233Val Single submitter ⚠
- p.Lys231Thr Single submitter ⚠
- p.Lys286Arg Single submitter ⚠
- p.Met271Ile Single submitter ⚠
- p.Met271Val Single submitter ⚠
- p.Pro232Ala Single submitter ⚠
- p.Pro45Arg Single submitter ⚠
- p.Ser311Pro Single submitter ⚠
- p.Ser38Asn Single submitter ⚠
- p.Thr184Met Single submitter ⚠
- p.Tyr150Cys Single submitter ⚠
- p.Tyr46His Single submitter ⚠
- p.Val312Met Single submitter ⚠
- p.Val59Leu Single submitter ⚠