SGK2 — 68 ClinVar variants
All ClinVar germline SGK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
1 Likely pathogenic · 2 Benign · 2 Benign/Likely benign · 3 Likely benign · 60 Uncertain significance
Full SGK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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SGK2 p.Arg127Gln
Likely pathogenic
No assertion criteria
colorectal cancer
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SGK2 p.Ala140Thr Uncertain significance Single submitter
- SGK2 p.Ala214Val Uncertain significance Single submitter
- SGK2 p.Ala261Thr Uncertain significance Single submitter
- SGK2 p.Arg100His Uncertain significance Single submitter
- SGK2 p.Arg257Gln Uncertain significance Single submitter
- SGK2 p.Arg257Trp Uncertain significance Single submitter
- SGK2 p.Arg54Cys Uncertain significance Single submitter
- SGK2 p.Arg84Cys Uncertain significance Single submitter
- SGK2 p.Arg84His Uncertain significance Single submitter
- SGK2 p.Asn21Ser Uncertain significance Single submitter
- SGK2 p.Asn296Ser Uncertain significance Single submitter
- SGK2 p.Asp216Val Uncertain significance Single submitter
- SGK2 p.Cys367Phe Uncertain significance Single submitter
- SGK2 p.Gly179Asp Uncertain significance Single submitter
- SGK2 p.Gly18Arg Uncertain significance Single submitter
- SGK2 p.Gly256Asp Uncertain significance Single submitter
- SGK2 p.Gly315Arg Uncertain significance Single submitter
- SGK2 p.Gly336Ala Uncertain significance Single submitter
- SGK2 p.Gly47Arg Uncertain significance Single submitter
- SGK2 p.Ile253Phe Uncertain significance Single submitter
- SGK2 p.Ile286Val Uncertain significance Single submitter
- SGK2 p.Ile71Val Uncertain significance Single submitter
- SGK2 p.Leu206Phe Uncertain significance Single submitter
- SGK2 p.Leu247Met Uncertain significance Single submitter
- SGK2 p.Lys303Asn Uncertain significance Single submitter
- SGK2 p.Met81Val Uncertain significance Single submitter
- SGK2 p.Phe234Leu Uncertain significance Single submitter
- SGK2 p.Pro106His Uncertain significance Single submitter
- SGK2 p.Pro13Ala Uncertain significance Single submitter
- SGK2 p.Pro232Leu Uncertain significance Single submitter
- SGK2 p.Pro24His Uncertain significance Single submitter
- SGK2 p.Pro24Ser Uncertain significance Single submitter
- SGK2 p.Pro24Thr Uncertain significance Single submitter
- SGK2 p.Pro28Leu Uncertain significance Single submitter
- SGK2 p.Ser344Arg Uncertain significance Single submitter
- SGK2 p.Thr105Ala Uncertain significance Single submitter
- SGK2 p.Thr176Met Uncertain significance Single submitter
- SGK2 p.Tyr115Ser Uncertain significance Single submitter
- SGK2 p.Tyr211His Uncertain significance Single submitter
- SGK2 p.Val185Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- SGK2 p.Arg207Gly Uncertain significance Single submitter
- SGK2 p.Arg92Trp Uncertain significance Single submitter
- SGK2 p.Glu107Lys Uncertain significance Single submitter
- SGK2 p.Met242Ile Uncertain significance Single submitter
- SGK2 p.Pro250Leu Uncertain significance Single submitter
- SGK2 p.Ser78Ile Uncertain significance Single submitter
- SGK2 p.Thr190Asn Uncertain significance Single submitter
All SGK2 variants
Likely pathogenic 1
- p.Arg127Gln No assertion criteria colorectal cancer ⚠
Benign 2
- c.228+8A>T Multiple submitters
- c.510+5GT[17] Multiple submitters
Benign/Likely benign 2
- c.510+5GT[16] Multiple submitters
- c.510+5GT[18] Multiple submitters
Likely benign 3
- c.510+7_510+8insGGGGTGTG Single submitter
- c.-23-94G>C Single submitter
- p.Arg92Gln Single submitter
Uncertain significance 60
- c.-23-109T>C Single submitter
- c.-23-139T>C Single submitter
- c.-23-144T>A Single submitter
- c.-23-150G>A Single submitter
- c.-23-31C>G Single submitter
- c.-23-3C>A Single submitter
- c.-23-55G>A Single submitter
- c.-23-73C>G Single submitter
- c.-23-75G>A Single submitter
- c.-23-97G>C Single submitter
- c.-23-9T>G Single submitter
- p.Ala140Thr Single submitter ⚠
- p.Ala214Val Single submitter ⚠
- p.Ala261Thr Single submitter ⚠
- p.Arg100His Single submitter ⚠
- p.Arg135Gln Single submitter
- p.Arg207Gly Single submitter ⚠
- p.Arg257Gln Single submitter ⚠
- p.Arg257Trp Single submitter ⚠
- p.Arg54Cys Single submitter ⚠
- p.Arg84Cys Single submitter ⚠
- p.Arg84His Single submitter ⚠
- p.Arg92Trp Single submitter ⚠
- p.Asn21Ser Single submitter ⚠
- p.Asn296Ser Single submitter ⚠
- p.Asp114Asn Single submitter
- p.Asp216Val Single submitter ⚠
- p.Cys367Phe Single submitter ⚠
- p.Glu107Lys Single submitter ⚠
- p.Gly179Asp Single submitter ⚠
- p.Gly18Arg Single submitter ⚠
- p.Gly256Asp Single submitter ⚠
- p.Gly315Arg Single submitter ⚠
- p.Gly336Ala Single submitter ⚠
- p.Gly47Arg Single submitter ⚠
- p.Ile253Phe Single submitter ⚠
- p.Ile286Val Single submitter ⚠
- p.Ile71Val Single submitter ⚠
- p.Leu206Phe Single submitter ⚠
- p.Leu247Met Single submitter ⚠
- p.Lys303Asn Single submitter ⚠
- p.Met242Ile Single submitter ⚠
- p.Met81Val Single submitter ⚠
- p.Phe234Leu Single submitter ⚠
- p.Pro106His Single submitter ⚠
- p.Pro13Ala Single submitter ⚠
- p.Pro232Leu Single submitter ⚠
- p.Pro24His Single submitter ⚠
- p.Pro24Ser Single submitter ⚠
- p.Pro24Thr Single submitter ⚠
- p.Pro250Leu Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Ser344Arg Single submitter ⚠
- p.Ser78Ile Single submitter ⚠
- p.Thr105Ala Single submitter ⚠
- p.Thr176Met Single submitter ⚠
- p.Thr190Asn Single submitter ⚠
- p.Tyr115Ser Single submitter ⚠
- p.Tyr211His Single submitter ⚠
- p.Val185Ala Single submitter ⚠