SHBG — 61 ClinVar variants
All ClinVar germline SHBG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
6 Benign · 9 Likely benign · 46 Uncertain significance
Full SHBG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SHBG p.Ala114Val Uncertain significance Single submitter
- SHBG p.Ala325Asp Uncertain significance Single submitter
- SHBG p.Ala39Thr Uncertain significance Single submitter
- SHBG p.Arg11Leu Uncertain significance Single submitter
- SHBG p.Arg195His Uncertain significance Single submitter
- SHBG p.Arg346His Uncertain significance Single submitter
- SHBG p.Asn338Lys Uncertain significance Single submitter
- SHBG p.Asn338Ser Uncertain significance Single submitter
- SHBG p.Asp201Glu Uncertain significance Single submitter
- SHBG p.Asp93Tyr Uncertain significance Single submitter
- SHBG p.Cys193Ser Uncertain significance Single submitter
- SHBG p.Gln258His Uncertain significance Single submitter
- SHBG p.Glu137Lys Uncertain significance Single submitter
- SHBG p.Gly158Ala Uncertain significance Single submitter
- SHBG p.Gly173Glu Uncertain significance Single submitter
- SHBG p.Gly365Ser Uncertain significance Single submitter
- SHBG p.Gly370Asp Uncertain significance Single submitter
- SHBG p.His110Gln Uncertain significance Single submitter
- SHBG p.His280Gln Uncertain significance Single submitter
- SHBG p.Leu109Val Uncertain significance Single submitter
- SHBG p.Leu265Phe Uncertain significance Single submitter
- SHBG p.Leu281Ile Uncertain significance Single submitter
- SHBG p.Lys309Thr Uncertain significance Single submitter
- SHBG p.Pro105Thr Uncertain significance Single submitter
- SHBG p.Pro159Thr Uncertain significance Single submitter
- SHBG p.Pro35Ser Uncertain significance Single submitter
- SHBG p.Pro42Leu Uncertain significance Single submitter
- SHBG p.Ser162Gly Uncertain significance Single submitter
- SHBG p.Ser162Ile Uncertain significance Single submitter
- SHBG p.Ser292Trp Uncertain significance Single submitter
- SHBG p.Ser321Trp Uncertain significance Single submitter
- SHBG p.Thr117Met Uncertain significance Single submitter
- SHBG p.Thr270Ile Uncertain significance Single submitter
- SHBG p.Thr398Asn Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- SHBG p.Arg195Cys Uncertain significance Single submitter
- SHBG p.Arg195Leu Uncertain significance Single submitter
- SHBG p.Asp239Val Uncertain significance Single submitter
- SHBG p.Gly27Arg Uncertain significance Single submitter
- SHBG p.Pro228Ala Uncertain significance Single submitter
- SHBG p.Trp199Ser Uncertain significance Single submitter
- SHBG p.Tyr86Cys Uncertain significance Single submitter
All SHBG variants
Benign 6
- p.Ala179Pro Multiple submitters
- p.Arg25His Multiple submitters
- p.Arg314= Multiple submitters
- p.Asp356Asn Multiple submitters
- p.His40= Multiple submitters
- p.Pro185Leu Single submitter
Likely benign 9
- p.Ala400Thr Single submitter
- p.Arg11His Single submitter
- p.Arg22His Single submitter
- p.His280Tyr Single submitter
- p.Ser289= Single submitter
- p.Val219= Single submitter
- c.394-10C>G No assertion criteria SHBG-related disorder
- p.Leu153= No assertion criteria SHBG-related disorder
- p.Ser278Asn No assertion criteria SHBG-related disorder
Uncertain significance 46
- p.Ala114Val Single submitter ⚠
- p.Ala325Asp Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Arg11Leu Single submitter ⚠
- p.Arg195Cys Single submitter ⚠
- p.Arg195His Single submitter ⚠
- p.Arg195Leu Single submitter ⚠
- p.Arg346His Single submitter ⚠
- p.Asn338Lys Single submitter ⚠
- p.Asn338Ser Single submitter ⚠
- p.Asp201Glu Single submitter ⚠
- p.Asp239Val Single submitter ⚠
- p.Asp93Tyr Single submitter ⚠
- p.Cys193Ser Single submitter ⚠
- p.Gln258His Single submitter ⚠
- p.Glu137Lys Single submitter ⚠
- p.Gly147Trp Single submitter
- p.Gly158Ala Single submitter ⚠
- p.Gly173Glu Single submitter ⚠
- p.Gly27Arg Single submitter ⚠
- p.Gly365Ser Single submitter ⚠
- p.Gly370Asp Single submitter ⚠
- p.His110Gln Single submitter ⚠
- p.His280Gln Single submitter ⚠
- p.Leu109Val Single submitter ⚠
- p.Leu265Phe Single submitter ⚠
- p.Leu281Ile Single submitter ⚠
- p.Leu339Pro Single submitter
- p.Lys309Thr Single submitter ⚠
- p.Met97Thr Single submitter
- p.Pro105Thr Single submitter ⚠
- p.Pro159Thr Single submitter ⚠
- p.Pro228Ala Single submitter ⚠
- p.Pro35Ser Single submitter ⚠
- p.Pro42Leu Single submitter ⚠
- p.Ser162Gly Single submitter ⚠
- p.Ser162Ile Single submitter ⚠
- p.Ser292Trp Single submitter ⚠
- p.Ser321Trp Single submitter ⚠
- p.Ser71Cys Single submitter
- p.Thr117Met Single submitter ⚠
- p.Thr270Ile Single submitter ⚠
- p.Thr398Asn Single submitter ⚠
- p.Trp199Ser Single submitter ⚠
- p.Tyr86Cys Single submitter ⚠
- p.Asp376Asn No assertion criteria Sex Hormone-Binding Globulin Deficiency