SHC1 — 67 ClinVar variants
All ClinVar germline SHC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
2 Likely benign · 65 Uncertain significance
Full SHC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SHC1 p.Ala373Thr Uncertain significance Single submitter
- SHC1 p.Ala373Val Uncertain significance Single submitter
- SHC1 p.Ala39Val Uncertain significance Single submitter
- SHC1 p.Arg207Thr Uncertain significance Single submitter
- SHC1 p.Arg311His Uncertain significance Single submitter
- SHC1 p.Arg369Trp Uncertain significance Single submitter
- SHC1 p.Arg378Gln Uncertain significance Single submitter
- SHC1 p.Arg438Trp Uncertain significance Single submitter
- SHC1 p.Arg457Gln Uncertain significance Single submitter
- SHC1 p.Arg544Trp Uncertain significance Single submitter
- SHC1 p.Arg549His Uncertain significance Single submitter
- SHC1 p.Arg582Gln Uncertain significance Single submitter
- SHC1 p.Arg77His Uncertain significance Single submitter
- SHC1 p.Asn11Ser Uncertain significance Single submitter
- SHC1 p.Asn452Ser Uncertain significance Single submitter
- SHC1 p.Asn506Ser Uncertain significance Single submitter
- SHC1 p.Asp89Asn Uncertain significance Single submitter
- SHC1 p.Cys416Trp Uncertain significance Single submitter
- SHC1 p.Cys416Tyr Uncertain significance Single submitter
- SHC1 p.Gln314Arg Uncertain significance Single submitter
- SHC1 p.Glu190Lys Uncertain significance Single submitter
- SHC1 p.Glu370Ala Uncertain significance Single submitter
- SHC1 p.Gly127Ser Uncertain significance Single submitter
- SHC1 p.Gly75Arg Uncertain significance Single submitter
- SHC1 p.Ile219Val Uncertain significance Single submitter
- SHC1 p.Ile232Val Uncertain significance Single submitter
- SHC1 p.Leu241Phe Uncertain significance Single submitter
- SHC1 p.Leu390Val Uncertain significance Single submitter
- SHC1 p.Pro106Arg Uncertain significance Single submitter
- SHC1 p.Pro200Leu Uncertain significance Single submitter
- SHC1 p.Pro215Leu Uncertain significance Single submitter
- SHC1 p.Pro387Arg Uncertain significance Single submitter
- SHC1 p.Pro415His Uncertain significance Single submitter
- SHC1 p.Pro446Arg Uncertain significance Single submitter
- SHC1 p.Pro447His Uncertain significance Single submitter
- SHC1 p.Pro47Ser Uncertain significance Single submitter
- SHC1 p.Pro5Ser Uncertain significance Single submitter
- SHC1 p.Pro73Leu Uncertain significance Single submitter
- SHC1 p.Ser115Cys Uncertain significance Single submitter
- SHC1 p.Ser239Gly Uncertain significance Single submitter
- SHC1 p.Thr515Met Uncertain significance Single submitter
- SHC1 p.Tyr276Cys Uncertain significance Single submitter
- SHC1 p.Tyr315Cys Uncertain significance Single submitter
- SHC1 p.Val363Met Uncertain significance Single submitter
- SHC1 p.Val95Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- SHC1 p.Arg146Pro Uncertain significance Single submitter
- SHC1 p.Arg497Gln Uncertain significance Single submitter
- SHC1 p.Arg64Trp Uncertain significance Single submitter
- SHC1 p.Asn563Ser Uncertain significance Single submitter
- SHC1 p.Asp327Gly Uncertain significance Single submitter
- SHC1 p.Asp467Glu Uncertain significance Single submitter
- SHC1 p.Glu500Lys Uncertain significance Single submitter
- SHC1 p.Gly362Ala Uncertain significance Single submitter
- SHC1 p.Gly362Arg Uncertain significance Single submitter
- SHC1 p.Gly362Glu Uncertain significance Single submitter
- SHC1 p.Gly362Val Uncertain significance Single submitter
- SHC1 p.Met329Ile Uncertain significance Single submitter
- SHC1 p.Pro456Leu Uncertain significance Single submitter
- SHC1 p.Ser454Arg Uncertain significance Single submitter
- SHC1 p.Val141Leu Uncertain significance Single submitter
All SHC1 variants
Likely benign 2
- p.Arg69Lys Single submitter
- p.Val400Ala Single submitter
Uncertain significance 65
- p.Ala373Thr Single submitter ⚠
- p.Ala373Val Single submitter ⚠
- p.Ala39Val Single submitter ⚠
- p.Arg146Pro Single submitter ⚠
- p.Arg207Thr Single submitter ⚠
- p.Arg214Cys Single submitter
- p.Arg311His Single submitter ⚠
- p.Arg369Trp Single submitter ⚠
- p.Arg378Gln Single submitter ⚠
- p.Arg438Trp Single submitter ⚠
- p.Arg457Gln Single submitter ⚠
- p.Arg497Gln Single submitter ⚠
- p.Arg497Trp Single submitter
- p.Arg544Trp Single submitter ⚠
- p.Arg549His Single submitter ⚠
- p.Arg582Gln Single submitter ⚠
- p.Arg64Trp Single submitter ⚠
- p.Arg77His Single submitter ⚠
- p.Asn11Ser Single submitter ⚠
- p.Asn452Ser Single submitter ⚠
- p.Asn506Ser Single submitter ⚠
- p.Asn563Ser Single submitter ⚠
- p.Asp327Gly Single submitter ⚠
- p.Asp467Glu Single submitter ⚠
- p.Asp89Asn Single submitter ⚠
- p.Cys416Trp Single submitter ⚠
- p.Cys416Tyr Single submitter ⚠
- p.Gln314Arg Single submitter ⚠
- p.Glu190Lys Single submitter ⚠
- p.Glu341Lys Single submitter
- p.Glu370Ala Single submitter ⚠
- p.Glu500Lys Single submitter ⚠
- p.Gly127Ser Single submitter ⚠
- p.Gly362Ala Single submitter ⚠
- p.Gly362Arg Single submitter ⚠
- p.Gly362Glu Single submitter ⚠
- p.Gly362Val Single submitter ⚠
- p.Gly75Arg Single submitter ⚠
- p.Ile219Val Single submitter ⚠
- p.Ile232Val Single submitter ⚠
- p.Leu241Phe Single submitter ⚠
- p.Leu390Val Single submitter ⚠
- p.Lys436Thr Single submitter
- p.Met329Ile Single submitter ⚠
- p.Pro106Arg Single submitter ⚠
- p.Pro200Leu Single submitter ⚠
- p.Pro215Leu Single submitter ⚠
- p.Pro387Arg Single submitter ⚠
- p.Pro415His Single submitter ⚠
- p.Pro446Arg Single submitter ⚠
- p.Pro447His Single submitter ⚠
- p.Pro456Leu Single submitter ⚠
- p.Pro47Ser Single submitter ⚠
- p.Pro5Ser Single submitter ⚠
- p.Pro73Leu Single submitter ⚠
- p.Ser115Cys Single submitter ⚠
- p.Ser223Asn Single submitter
- p.Ser239Gly Single submitter ⚠
- p.Ser454Arg Single submitter ⚠
- p.Thr515Met Single submitter ⚠
- p.Tyr276Cys Single submitter ⚠
- p.Tyr315Cys Single submitter ⚠
- p.Val141Leu Single submitter ⚠
- p.Val363Met Single submitter ⚠
- p.Val95Ile Single submitter ⚠