SIGLEC7 — 64 ClinVar variants
All ClinVar germline SIGLEC7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
1 Benign · 63 Uncertain significance
Full SIGLEC7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SIGLEC7 p.Arg198Cys Uncertain significance Multiple submitters
- SIGLEC7 p.Ala113Thr Uncertain significance Single submitter
- SIGLEC7 p.Ala118Val Uncertain significance Single submitter
- SIGLEC7 p.Arg23Gln Uncertain significance Single submitter
- SIGLEC7 p.Arg321Gln Uncertain significance Single submitter
- SIGLEC7 p.Arg385Lys Uncertain significance Single submitter
- SIGLEC7 p.Arg45His Uncertain significance Single submitter
- SIGLEC7 p.Arg92Gln Uncertain significance Single submitter
- SIGLEC7 p.Asn165Ser Uncertain significance Single submitter
- SIGLEC7 p.Asn235Ser Uncertain significance Single submitter
- SIGLEC7 p.Asn281Ser Uncertain significance Single submitter
- SIGLEC7 p.Asn399Lys Uncertain significance Single submitter
- SIGLEC7 p.Asp112Gly Uncertain significance Single submitter
- SIGLEC7 p.Asp392Glu Uncertain significance Single submitter
- SIGLEC7 p.Asp417Tyr Uncertain significance Single submitter
- SIGLEC7 p.Cys46Arg Uncertain significance Single submitter
- SIGLEC7 p.Gln407Arg Uncertain significance Single submitter
- SIGLEC7 p.Glu14Asp Uncertain significance Single submitter
- SIGLEC7 p.Gly354Ala Uncertain significance Single submitter
- SIGLEC7 p.Gly354Arg Uncertain significance Single submitter
- SIGLEC7 p.Gly357Arg Uncertain significance Single submitter
- SIGLEC7 p.Gly403Arg Uncertain significance Single submitter
- SIGLEC7 p.His210Gln Uncertain significance Single submitter
- SIGLEC7 p.His43Pro Uncertain significance Single submitter
- SIGLEC7 p.Ile130Thr Uncertain significance Single submitter
- SIGLEC7 p.Lys20Asn Uncertain significance Single submitter
- SIGLEC7 p.Lys24Thr Uncertain significance Single submitter
- SIGLEC7 p.Lys75Arg Uncertain significance Single submitter
- SIGLEC7 p.Met115Thr Uncertain significance Single submitter
- SIGLEC7 p.Met345Ile Uncertain significance Single submitter
- SIGLEC7 p.Phe373Leu Uncertain significance Single submitter
- SIGLEC7 p.Ser109Asn Uncertain significance Single submitter
- SIGLEC7 p.Ser383Leu Uncertain significance Single submitter
- SIGLEC7 p.Ser404Pro Uncertain significance Single submitter
- SIGLEC7 p.Thr203Asn Uncertain significance Single submitter
- SIGLEC7 p.Thr342Ile Uncertain significance Single submitter
- SIGLEC7 p.Thr400Ile Uncertain significance Single submitter
- SIGLEC7 p.Trp65Gly Uncertain significance Single submitter
- SIGLEC7 p.Val189Leu Uncertain significance Single submitter
- SIGLEC7 p.Val356Ala Uncertain significance Single submitter
- SIGLEC7 p.Val390Met Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- SIGLEC7 p.Gln207Pro Uncertain significance Single submitter
- SIGLEC7 p.Gly128Glu Uncertain significance Single submitter
- SIGLEC7 p.Gly177Arg Uncertain significance Single submitter
- SIGLEC7 p.Gly186Glu Uncertain significance Single submitter
- SIGLEC7 p.Gly223Glu Uncertain significance Single submitter
- SIGLEC7 p.Gly269Arg Uncertain significance Single submitter
- SIGLEC7 p.Ile232Met Uncertain significance Single submitter
- SIGLEC7 p.Leu258Met Uncertain significance Single submitter
- SIGLEC7 p.Leu274Phe Uncertain significance Single submitter
- SIGLEC7 p.Leu295Pro Uncertain significance Single submitter
- SIGLEC7 p.Leu97Phe Uncertain significance Single submitter
- SIGLEC7 p.Phe66Val Uncertain significance Single submitter
- SIGLEC7 p.Pro77Ser Uncertain significance Single submitter
- SIGLEC7 p.Ser280Arg Uncertain significance Single submitter
- SIGLEC7 p.Ser49Cys Uncertain significance Single submitter
- SIGLEC7 p.Thr178Met Uncertain significance Single submitter
- SIGLEC7 p.Val143Leu Uncertain significance Single submitter
- SIGLEC7 p.Val170Met Uncertain significance Single submitter
- SIGLEC7 p.Val226Met Uncertain significance Single submitter
- SIGLEC7 p.Val36Met Uncertain significance Single submitter
- SIGLEC7 p.Val371Asp Uncertain significance Single submitter
All SIGLEC7 variants
Benign 1
- p.Met181Val Multiple submitters
Uncertain significance 63
- p.Arg198Cys Multiple submitters ⚠
- p.Ala113Thr Single submitter ⚠
- p.Ala118Val Single submitter ⚠
- p.Arg23Gln Single submitter ⚠
- p.Arg321Gln Single submitter ⚠
- p.Arg385Lys Single submitter ⚠
- p.Arg45His Single submitter ⚠
- p.Arg92Gln Single submitter ⚠
- p.Asn165Ser Single submitter ⚠
- p.Asn235Ser Single submitter ⚠
- p.Asn281Ser Single submitter ⚠
- p.Asn399Lys Single submitter ⚠
- p.Asp112Gly Single submitter ⚠
- p.Asp392Glu Single submitter ⚠
- p.Asp417Tyr Single submitter ⚠
- p.Cys46Arg Single submitter ⚠
- p.Gln207Pro Single submitter ⚠
- p.Gln407Arg Single submitter ⚠
- p.Glu14Asp Single submitter ⚠
- p.Gly128Glu Single submitter ⚠
- p.Gly177Arg Single submitter ⚠
- p.Gly186Glu Single submitter ⚠
- p.Gly223Glu Single submitter ⚠
- p.Gly269Arg Single submitter ⚠
- p.Gly354Ala Single submitter ⚠
- p.Gly354Arg Single submitter ⚠
- p.Gly357Arg Single submitter ⚠
- p.Gly403Arg Single submitter ⚠
- p.His210Gln Single submitter ⚠
- p.His43Pro Single submitter ⚠
- p.Ile130Thr Single submitter ⚠
- p.Ile232Met Single submitter ⚠
- p.Leu258Met Single submitter ⚠
- p.Leu274Phe Single submitter ⚠
- p.Leu295Pro Single submitter ⚠
- p.Leu97Phe Single submitter ⚠
- p.Lys20Asn Single submitter ⚠
- p.Lys24Thr Single submitter ⚠
- p.Lys75Arg Single submitter ⚠
- p.Met115Thr Single submitter ⚠
- p.Met345Ile Single submitter ⚠
- p.Phe373Leu Single submitter ⚠
- p.Phe66Val Single submitter ⚠
- p.Pro77Ser Single submitter ⚠
- p.Ser109Asn Single submitter ⚠
- p.Ser280Arg Single submitter ⚠
- p.Ser383Leu Single submitter ⚠
- p.Ser404Pro Single submitter ⚠
- p.Ser49Cys Single submitter ⚠
- p.Thr178Met Single submitter ⚠
- p.Thr203Asn Single submitter ⚠
- p.Thr342Ile Single submitter ⚠
- p.Thr400Ile Single submitter ⚠
- p.Trp65Gly Single submitter ⚠
- p.Val143Leu Single submitter ⚠
- p.Val143Met Single submitter
- p.Val170Met Single submitter ⚠
- p.Val189Leu Single submitter ⚠
- p.Val226Met Single submitter ⚠
- p.Val356Ala Single submitter ⚠
- p.Val36Met Single submitter ⚠
- p.Val371Asp Single submitter ⚠
- p.Val390Met Single submitter ⚠