SIGLEC9 — 65 ClinVar variants
All ClinVar germline SIGLEC9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
3 Benign · 3 Likely benign · 59 Uncertain significance
Full SIGLEC9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SIGLEC9 p.Ala15Glu Uncertain significance Single submitter
- SIGLEC9 p.Ala382Val Uncertain significance Single submitter
- SIGLEC9 p.Arg134Trp Uncertain significance Single submitter
- SIGLEC9 p.Arg14Met Uncertain significance Single submitter
- SIGLEC9 p.Arg194His Uncertain significance Single submitter
- SIGLEC9 p.Arg321Gly Uncertain significance Single submitter
- SIGLEC9 p.Arg321Lys Uncertain significance Single submitter
- SIGLEC9 p.Arg81Leu Uncertain significance Single submitter
- SIGLEC9 p.Arg90Gly Uncertain significance Single submitter
- SIGLEC9 p.Asn225Asp Uncertain significance Single submitter
- SIGLEC9 p.Asn67Asp Uncertain significance Single submitter
- SIGLEC9 p.Asn67Ser Uncertain significance Single submitter
- SIGLEC9 p.Cys320Arg Uncertain significance Single submitter
- SIGLEC9 p.Gln323His Uncertain significance Single submitter
- SIGLEC9 p.Gln338Arg Uncertain significance Single submitter
- SIGLEC9 p.Glu155Gln Uncertain significance Single submitter
- SIGLEC9 p.Gly248Ser Uncertain significance Single submitter
- SIGLEC9 p.Gly303Arg Uncertain significance Single submitter
- SIGLEC9 p.Gly354Ala Uncertain significance Single submitter
- SIGLEC9 p.His38Tyr Uncertain significance Single submitter
- SIGLEC9 p.His48Arg Uncertain significance Single submitter
- SIGLEC9 p.Ile389Val Uncertain significance Single submitter
- SIGLEC9 p.Ile51Val Uncertain significance Single submitter
- SIGLEC9 p.Leu337Gln Uncertain significance Single submitter
- SIGLEC9 p.Pro176Ser Uncertain significance Single submitter
- SIGLEC9 p.Pro296Leu Uncertain significance Single submitter
- SIGLEC9 p.Pro302Leu Uncertain significance Single submitter
- SIGLEC9 p.Pro55Leu Uncertain significance Single submitter
- SIGLEC9 p.Ser186Phe Uncertain significance Single submitter
- SIGLEC9 p.Ser20Thr Uncertain significance Single submitter
- SIGLEC9 p.Ser343Leu Uncertain significance Single submitter
- SIGLEC9 p.Ser377Leu Uncertain significance Single submitter
- SIGLEC9 p.Ser400Phe Uncertain significance Single submitter
- SIGLEC9 p.Thr192Ile Uncertain significance Single submitter
- SIGLEC9 p.Thr19Ile Uncertain significance Single submitter
- SIGLEC9 p.Thr224Met Uncertain significance Single submitter
- SIGLEC9 p.Thr30Ser Uncertain significance Single submitter
- SIGLEC9 p.Thr356Ile Uncertain significance Single submitter
- SIGLEC9 p.Thr387Ala Uncertain significance Single submitter
- SIGLEC9 p.Thr387Met Uncertain significance Single submitter
- SIGLEC9 p.Trp309Ser Uncertain significance Single submitter
- SIGLEC9 p.Trp61Arg Uncertain significance Single submitter
- SIGLEC9 p.Val185Met Uncertain significance Single submitter
- SIGLEC9 p.Val222Met Uncertain significance Single submitter
- SIGLEC9 p.Val384Met Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- SIGLEC9 p.Arg120Cys Uncertain significance Single submitter
- SIGLEC9 p.Arg120His Uncertain significance Single submitter
- SIGLEC9 p.Asn324Lys Uncertain significance Single submitter
- SIGLEC9 p.Gly327Ser Uncertain significance Single submitter
- SIGLEC9 p.Leu333Gln Uncertain significance Single submitter
- SIGLEC9 p.Pro79Leu Uncertain significance Single submitter
- SIGLEC9 p.Ser196Leu Uncertain significance Single submitter
- SIGLEC9 p.Thr212Ile Uncertain significance Single submitter
- SIGLEC9 p.Thr30Met Uncertain significance Single submitter
- SIGLEC9 p.Thr319Asn Uncertain significance Single submitter
- SIGLEC9 p.Thr87Ile Uncertain significance Single submitter
- SIGLEC9 p.Trp50Cys Uncertain significance Single submitter
All SIGLEC9 variants
Benign 3
- p.Ala382= Multiple submitters
- p.Asn393= Multiple submitters
- p.Ser125Asn Multiple submitters
Likely benign 3
- p.Leu6= Single submitter
- p.Met241Val Single submitter
- p.Val365Ile Single submitter
Uncertain significance 59
- p.Ala15Glu Single submitter ⚠
- p.Ala382Val Single submitter ⚠
- p.Arg120Cys Single submitter ⚠
- p.Arg120His Single submitter ⚠
- p.Arg134Trp Single submitter ⚠
- p.Arg14Met Single submitter ⚠
- p.Arg194His Single submitter ⚠
- p.Arg321Gly Single submitter ⚠
- p.Arg321Lys Single submitter ⚠
- p.Arg81Leu Single submitter ⚠
- p.Arg90Gly Single submitter ⚠
- p.Asn225Asp Single submitter ⚠
- p.Asn324Lys Single submitter ⚠
- p.Asn67Asp Single submitter ⚠
- p.Asn67Ser Single submitter ⚠
- p.Cys320Arg Single submitter ⚠
- p.Gln323His Single submitter ⚠
- p.Gln338Arg Single submitter ⚠
- p.Glu155Gln Single submitter ⚠
- p.Gly248Ser Single submitter ⚠
- p.Gly303Arg Single submitter ⚠
- p.Gly327Ser Single submitter ⚠
- p.Gly34Ala Single submitter
- p.Gly354Ala Single submitter ⚠
- p.His38Tyr Single submitter ⚠
- p.His48Arg Single submitter ⚠
- p.Ile389Val Single submitter ⚠
- p.Ile51Val Single submitter ⚠
- p.Leu333Gln Single submitter ⚠
- p.Leu337Gln Single submitter ⚠
- p.Pro176Ser Single submitter ⚠
- p.Pro296Leu Single submitter ⚠
- p.Pro302Leu Single submitter ⚠
- p.Pro55Leu Single submitter ⚠
- p.Pro79Leu Single submitter ⚠
- p.Ser186Phe Single submitter ⚠
- p.Ser196Leu Single submitter ⚠
- p.Ser20Thr Single submitter ⚠
- p.Ser343Leu Single submitter ⚠
- p.Ser377Leu Single submitter ⚠
- p.Ser400Phe Single submitter ⚠
- p.Thr103Pro Single submitter
- p.Thr192Ile Single submitter ⚠
- p.Thr19Ile Single submitter ⚠
- p.Thr212Ile Single submitter ⚠
- p.Thr224Met Single submitter ⚠
- p.Thr30Met Single submitter ⚠
- p.Thr30Ser Single submitter ⚠
- p.Thr319Asn Single submitter ⚠
- p.Thr356Ile Single submitter ⚠
- p.Thr387Ala Single submitter ⚠
- p.Thr387Met Single submitter ⚠
- p.Thr87Ile Single submitter ⚠
- p.Trp309Ser Single submitter ⚠
- p.Trp50Cys Single submitter ⚠
- p.Trp61Arg Single submitter ⚠
- p.Val185Met Single submitter ⚠
- p.Val222Met Single submitter ⚠
- p.Val384Met Single submitter ⚠