SIRT2 — 68 ClinVar variants
All ClinVar germline SIRT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
5 Benign · 1 Likely benign · 62 Uncertain significance
Full SIRT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SIRT2 p.Ala241Val Uncertain significance Single submitter
- SIRT2 p.Ala276Val Uncertain significance Single submitter
- SIRT2 p.Ala31Ser Uncertain significance Single submitter
- SIRT2 p.Ala358Gly Uncertain significance Single submitter
- SIRT2 p.Ala91Gly Uncertain significance Single submitter
- SIRT2 p.Arg163His Uncertain significance Single submitter
- SIRT2 p.Arg282His Uncertain significance Single submitter
- SIRT2 p.Arg385Trp Uncertain significance Single submitter
- SIRT2 p.Arg42Gln Uncertain significance Single submitter
- SIRT2 p.Arg57His Uncertain significance Single submitter
- SIRT2 p.Arg69Gln Uncertain significance Single submitter
- SIRT2 p.Arg75His Uncertain significance Single submitter
- SIRT2 p.Arg77Gly Uncertain significance Single submitter
- SIRT2 p.Arg78Ser Uncertain significance Single submitter
- SIRT2 p.Arg97Cys Uncertain significance Single submitter
- SIRT2 p.Asp170Gly Uncertain significance Single submitter
- SIRT2 p.Cys246Ser Uncertain significance Single submitter
- SIRT2 p.Glu185Gln Uncertain significance Single submitter
- SIRT2 p.Glu203Lys Uncertain significance Single submitter
- SIRT2 p.Glu379Lys Uncertain significance Single submitter
- SIRT2 p.Gly102Ser Uncertain significance Single submitter
- SIRT2 p.Gly177Arg Uncertain significance Single submitter
- SIRT2 p.Gly236Asp Uncertain significance Single submitter
- SIRT2 p.Gly322Ser Uncertain significance Single submitter
- SIRT2 p.Gly34Arg Uncertain significance Single submitter
- SIRT2 p.Ile147Thr Uncertain significance Single submitter
- SIRT2 p.Ile87Phe Uncertain significance Single submitter
- SIRT2 p.Leu283Pro Uncertain significance Single submitter
- SIRT2 p.Met247Ile Uncertain significance Single submitter
- SIRT2 p.Phe124Leu Uncertain significance Single submitter
- SIRT2 p.Phe131Val Uncertain significance Single submitter
- SIRT2 p.Pro115Leu Uncertain significance Single submitter
- SIRT2 p.Pro140Leu Uncertain significance Single submitter
- SIRT2 p.Pro369Ser Uncertain significance Single submitter
- SIRT2 p.Pro373Leu Uncertain significance Single submitter
- SIRT2 p.Pro374Thr Uncertain significance Single submitter
- SIRT2 p.Ser293Leu Uncertain significance Single submitter
- SIRT2 p.Ser351Gly Uncertain significance Single submitter
- SIRT2 p.Thr218Met Uncertain significance Single submitter
- SIRT2 p.Thr262Ile Uncertain significance Single submitter
- SIRT2 p.Thr89Ala Uncertain significance Single submitter
- SIRT2 p.Tyr165Asn Uncertain significance Single submitter
- SIRT2 p.Val233Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- SIRT2 p.Arg153His Benign Multiple submitters
- SIRT2 p.Ala354Gly Uncertain significance Single submitter
- SIRT2 p.Arg174Gln Uncertain significance Single submitter
- SIRT2 p.Arg242Gly Uncertain significance Single submitter
- SIRT2 p.Arg242His Uncertain significance Single submitter
- SIRT2 p.Arg346Trp Uncertain significance Single submitter
- SIRT2 p.Arg57Cys Uncertain significance Single submitter
- SIRT2 p.Arg69Trp Uncertain significance Single submitter
- SIRT2 p.Arg75Cys Uncertain significance Single submitter
- SIRT2 p.Arg77Cys Uncertain significance Single submitter
- SIRT2 p.Asp294Tyr Uncertain significance Single submitter
- SIRT2 p.Asp308Val Uncertain significance Single submitter
- SIRT2 p.Asp325Asn Uncertain significance Single submitter
- SIRT2 p.Gln267His Uncertain significance Single submitter
- SIRT2 p.Glu323Lys Uncertain significance Single submitter
- SIRT2 p.Ile232Val Uncertain significance Single submitter
- SIRT2 p.Leu107Ile Uncertain significance Single submitter
- SIRT2 p.Leu64Phe Uncertain significance Single submitter
- SIRT2 p.Ser27Cys Uncertain significance Single submitter
- SIRT2 p.Ser73Asn Uncertain significance Single submitter
All SIRT2 variants
Benign 5
- p.Arg153His Multiple submitters ⚠
- p.Leu344Ile Multiple submitters
- p.Leu44Phe Multiple submitters
- p.Ala198Thr Single submitter
- p.Ala358= Single submitter
Likely benign 1
- p.Phe132= Single submitter
Uncertain significance 62
- p.Ala241Val Single submitter ⚠
- p.Ala276Val Single submitter ⚠
- p.Ala31Ser Single submitter ⚠
- p.Ala354Gly Single submitter ⚠
- p.Ala358Gly Single submitter ⚠
- p.Ala91Gly Single submitter ⚠
- p.Arg163His Single submitter ⚠
- p.Arg174Gln Single submitter ⚠
- p.Arg242Gly Single submitter ⚠
- p.Arg242His Single submitter ⚠
- p.Arg282His Single submitter ⚠
- p.Arg346Trp Single submitter ⚠
- p.Arg385Trp Single submitter ⚠
- p.Arg42Gln Single submitter ⚠
- p.Arg57Cys Single submitter ⚠
- p.Arg57His Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Arg69Trp Single submitter ⚠
- p.Arg75Cys Single submitter ⚠
- p.Arg75His Single submitter ⚠
- p.Arg77Cys Single submitter ⚠
- p.Arg77Gly Single submitter ⚠
- p.Arg78Ser Single submitter ⚠
- p.Arg97Cys Single submitter ⚠
- p.Asp170Gly Single submitter ⚠
- p.Asp294Tyr Single submitter ⚠
- p.Asp308Val Single submitter ⚠
- p.Asp325Asn Single submitter ⚠
- p.Cys246Ser Single submitter ⚠
- p.Gln267His Single submitter ⚠
- p.Glu185Gln Single submitter ⚠
- p.Glu203Lys Single submitter ⚠
- p.Glu323Lys Single submitter ⚠
- p.Glu379Lys Single submitter ⚠
- p.Gly102Ser Single submitter ⚠
- p.Gly177Arg Single submitter ⚠
- p.Gly236Asp Single submitter ⚠
- p.Gly322Ser Single submitter ⚠
- p.Gly34Arg Single submitter ⚠
- p.Ile147Thr Single submitter ⚠
- p.Ile232Val Single submitter ⚠
- p.Ile87Phe Single submitter ⚠
- p.Leu107Ile Single submitter ⚠
- p.Leu283Pro Single submitter ⚠
- p.Leu64Phe Single submitter ⚠
- p.Met247Ile Single submitter ⚠
- p.Phe124Leu Single submitter ⚠
- p.Phe131Val Single submitter ⚠
- p.Pro115Leu Single submitter ⚠
- p.Pro140Leu Single submitter ⚠
- p.Pro369Ser Single submitter ⚠
- p.Pro373Leu Single submitter ⚠
- p.Pro374Thr Single submitter ⚠
- p.Ser27Cys Single submitter ⚠
- p.Ser293Leu Single submitter ⚠
- p.Ser351Gly Single submitter ⚠
- p.Ser73Asn Single submitter ⚠
- p.Thr218Met Single submitter ⚠
- p.Thr262Ile Single submitter ⚠
- p.Thr89Ala Single submitter ⚠
- p.Tyr165Asn Single submitter ⚠
- p.Val233Ile Single submitter ⚠