SIRT7 — 50 ClinVar variants
All ClinVar germline SIRT7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
2 Likely benign · 48 Uncertain significance
Full SIRT7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SIRT7 p.Ala253Val Uncertain significance Single submitter
- SIRT7 p.Ala254Val Uncertain significance Single submitter
- SIRT7 p.Ala332Val Uncertain significance Single submitter
- SIRT7 p.Ala99Ser Uncertain significance Single submitter
- SIRT7 p.Arg154Cys Uncertain significance Single submitter
- SIRT7 p.Arg16Gln Uncertain significance Single submitter
- SIRT7 p.Arg16Leu Uncertain significance Single submitter
- SIRT7 p.Arg180His Uncertain significance Single submitter
- SIRT7 p.Arg213His Uncertain significance Single submitter
- SIRT7 p.Arg223Trp Uncertain significance Single submitter
- SIRT7 p.Arg279His Uncertain significance Single submitter
- SIRT7 p.Arg290Trp Uncertain significance Single submitter
- SIRT7 p.Arg372Trp Uncertain significance Single submitter
- SIRT7 p.Arg393Pro Uncertain significance Single submitter
- SIRT7 p.Arg49Gln Uncertain significance Single submitter
- SIRT7 p.Arg74Gln Uncertain significance Single submitter
- SIRT7 p.Asp118Gly Uncertain significance Single submitter
- SIRT7 p.Asp371Val Uncertain significance Single submitter
- SIRT7 p.Cys390Arg Uncertain significance Single submitter
- SIRT7 p.Glu142Lys Uncertain significance Single submitter
- SIRT7 p.Glu252Gly Uncertain significance Single submitter
- SIRT7 p.Gly188Arg Uncertain significance Single submitter
- SIRT7 p.His156Arg Uncertain significance Single submitter
- SIRT7 p.His187Arg Uncertain significance Single submitter
- SIRT7 p.Leu216Phe Uncertain significance Single submitter
- SIRT7 p.Leu267Val Uncertain significance Single submitter
- SIRT7 p.Leu274Pro Uncertain significance Single submitter
- SIRT7 p.Leu61Val Uncertain significance Single submitter
- SIRT7 p.Met150Thr Uncertain significance Single submitter
- SIRT7 p.Phe239Leu Uncertain significance Single submitter
- SIRT7 p.Pro287Arg Uncertain significance Single submitter
- SIRT7 p.Pro346Ser Uncertain significance Single submitter
- SIRT7 p.Pro368Ala Uncertain significance Single submitter
- SIRT7 p.Pro375Leu Uncertain significance Single submitter
- SIRT7 p.Pro82Arg Uncertain significance Single submitter
- SIRT7 p.Ser342Leu Uncertain significance Single submitter
- SIRT7 p.Ser44Thr Uncertain significance Single submitter
- SIRT7 p.Ser9Cys Uncertain significance Single submitter
- SIRT7 p.Thr106Arg Uncertain significance Single submitter
- SIRT7 p.Trp336Cys Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All SIRT7 variants
Likely benign 2
- p.Arg372Gln Single submitter
- p.Ser136= Single submitter
Uncertain significance 48
- p.Ala253Val Single submitter ⚠
- p.Ala254Val Single submitter ⚠
- p.Ala332Val Single submitter ⚠
- p.Ala99Ser Single submitter ⚠
- p.Arg154Cys Single submitter ⚠
- p.Arg16Gln Single submitter ⚠
- p.Arg16Leu Single submitter ⚠
- p.Arg180Cys Single submitter
- p.Arg180His Single submitter ⚠
- p.Arg213His Single submitter ⚠
- p.Arg223Trp Single submitter ⚠
- p.Arg279His Single submitter ⚠
- p.Arg290Trp Single submitter ⚠
- p.Arg372Trp Single submitter ⚠
- p.Arg393Pro Single submitter ⚠
- p.Arg49Gln Single submitter ⚠
- p.Arg49Gly Single submitter ⚠
- p.Arg49Trp Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Arg8Ser Single submitter ⚠
- p.Asp118Gly Single submitter ⚠
- p.Asp371Val Single submitter ⚠
- p.Cys390Arg Single submitter ⚠
- p.Glu142Lys Single submitter ⚠
- p.Glu252Gly Single submitter ⚠
- p.Gly188Arg Single submitter ⚠
- p.Gly350Asp Single submitter ⚠
- p.His156Arg Single submitter ⚠
- p.His187Arg Single submitter ⚠
- p.Ile295Val Single submitter ⚠
- p.Leu216Phe Single submitter ⚠
- p.Leu267Val Single submitter ⚠
- p.Leu274Pro Single submitter ⚠
- p.Leu347Pro Single submitter
- p.Leu61Val Single submitter ⚠
- p.Leu92Met Single submitter
- p.Met150Thr Single submitter ⚠
- p.Phe239Leu Single submitter ⚠
- p.Pro287Arg Single submitter ⚠
- p.Pro346Ser Single submitter ⚠
- p.Pro368Ala Single submitter ⚠
- p.Pro375Leu Single submitter ⚠
- p.Pro82Arg Single submitter ⚠
- p.Ser342Leu Single submitter ⚠
- p.Ser44Thr Single submitter ⚠
- p.Ser9Cys Single submitter ⚠
- p.Thr106Arg Single submitter ⚠
- p.Trp336Cys Single submitter ⚠