SKIC8 — 23 ClinVar variants
All ClinVar germline SKIC8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
23 Uncertain significance
Full SKIC8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SKIC8 p.Ala86Val Uncertain significance Single submitter
- SKIC8 p.Arg264Lys Uncertain significance Single submitter
- SKIC8 p.Asn31Asp Uncertain significance Single submitter
- SKIC8 p.Asn3Thr Uncertain significance Single submitter
- SKIC8 p.Asp16Asn Uncertain significance Single submitter
- SKIC8 p.Glu33Gln Uncertain significance Single submitter
- SKIC8 p.Gly262Ala Uncertain significance Single submitter
- SKIC8 p.His299Tyr Uncertain significance Single submitter
- SKIC8 p.Ile168Arg Uncertain significance Single submitter
- SKIC8 p.Ile305Val Uncertain significance Single submitter
- SKIC8 p.Leu228Pro Uncertain significance Single submitter
- SKIC8 p.Pro200Leu Uncertain significance Single submitter
- SKIC8 p.Ser137Thr Uncertain significance Single submitter
- SKIC8 p.Ser59Arg Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- SKIC8 p.Arg89His Uncertain significance Single submitter
- SKIC8 p.Asp108Glu Uncertain significance Single submitter
- SKIC8 p.Gly105Glu Uncertain significance Single submitter
- SKIC8 p.Ile99Met Uncertain significance Single submitter
- SKIC8 p.Leu76Val Uncertain significance Single submitter
- SKIC8 p.Pro200Arg Uncertain significance Single submitter
- SKIC8 p.Ser233Phe Uncertain significance Single submitter
All SKIC8 variants
Uncertain significance 23
- p.Ala86Val Single submitter ⚠
- p.Arg264Lys Single submitter ⚠
- p.Arg89His Single submitter ⚠
- p.Asn31Asp Single submitter ⚠
- p.Asn3Thr Single submitter ⚠
- p.Asp108Glu Single submitter ⚠
- p.Asp16Asn Single submitter ⚠
- p.Gln203Leu Single submitter
- p.Glu33Gln Single submitter ⚠
- p.Gly105Glu Single submitter ⚠
- p.Gly262Ala Single submitter ⚠
- p.His299Tyr Single submitter ⚠
- p.Ile168Arg Single submitter ⚠
- p.Ile300Met Single submitter
- p.Ile305Val Single submitter ⚠
- p.Ile99Met Single submitter ⚠
- p.Leu228Pro Single submitter ⚠
- p.Leu76Val Single submitter ⚠
- p.Pro200Arg Single submitter ⚠
- p.Pro200Leu Single submitter ⚠
- p.Ser137Thr Single submitter ⚠
- p.Ser233Phe Single submitter ⚠
- p.Ser59Arg Single submitter ⚠