SKP2 — 35 ClinVar variants
All ClinVar germline SKP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Likely benign · 34 Uncertain significance
Full SKP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SKP2 p.Arg182Cys Uncertain significance Single submitter
- SKP2 p.Asn231Tyr Uncertain significance Single submitter
- SKP2 p.Asn406Asp Uncertain significance Single submitter
- SKP2 p.Asn91Asp Uncertain significance Single submitter
- SKP2 p.Asn91Lys Uncertain significance Single submitter
- SKP2 p.Asp11Ala Uncertain significance Single submitter
- SKP2 p.Asp11Val Uncertain significance Single submitter
- SKP2 p.Gln287Glu Uncertain significance Single submitter
- SKP2 p.Gly242Val Uncertain significance Single submitter
- SKP2 p.Ile409Thr Uncertain significance Single submitter
- SKP2 p.Leu261Val Uncertain significance Single submitter
- SKP2 p.Leu353Val Uncertain significance Single submitter
- SKP2 p.Leu378Val Uncertain significance Single submitter
- SKP2 p.Leu424Gln Uncertain significance Single submitter
- SKP2 p.Lys324Thr Uncertain significance Single submitter
- SKP2 p.Pro149Leu Uncertain significance Single submitter
- SKP2 p.Pro62Arg Uncertain significance Single submitter
- SKP2 p.Ser14Gly Uncertain significance Single submitter
- SKP2 p.Ser241Cys Uncertain significance Single submitter
- SKP2 p.Ser26Phe Uncertain significance Single submitter
- SKP2 p.Ser422Arg Uncertain significance Single submitter
- SKP2 p.Thr152Ala Uncertain significance Single submitter
- SKP2 p.Val233Ala Uncertain significance Single submitter
- SKP2 p.Val371Met Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All SKP2 variants
Likely benign 1
- c.*1809A>G Single submitter
Uncertain significance 34
- c.*1825G>A Single submitter
- c.*1833G>C Single submitter
- c.*1846T>C Single submitter
- c.*1871A>C Single submitter
- c.*1900A>G Single submitter
- c.*1918G>A Single submitter
- c.*1939G>T Single submitter
- p.Arg182Cys Single submitter ⚠
- p.Asn231Tyr Single submitter ⚠
- p.Asn406Asp Single submitter ⚠
- p.Asn91Asp Single submitter ⚠
- p.Asn91Lys Single submitter ⚠
- p.Asp11Ala Single submitter ⚠
- p.Asp11Val Single submitter ⚠
- p.Asp373Tyr Single submitter
- p.Gln287Glu Single submitter ⚠
- p.Gly215Cys Single submitter ⚠
- p.Gly242Val Single submitter ⚠
- p.Ile359Thr Single submitter ⚠
- p.Ile409Thr Single submitter ⚠
- p.Leu261Val Single submitter ⚠
- p.Leu353Val Single submitter ⚠
- p.Leu378Val Single submitter ⚠
- p.Leu424Gln Single submitter ⚠
- p.Lys324Thr Single submitter ⚠
- p.Pro149Leu Single submitter ⚠
- p.Pro62Arg Single submitter ⚠
- p.Ser14Gly Single submitter ⚠
- p.Ser241Cys Single submitter ⚠
- p.Ser26Phe Single submitter ⚠
- p.Ser422Arg Single submitter ⚠
- p.Thr152Ala Single submitter ⚠
- p.Val233Ala Single submitter ⚠
- p.Val371Met Single submitter ⚠