SLC15A1 — 103 ClinVar variants
All ClinVar germline SLC15A1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →
5 Benign · 8 Likely benign · 90 Uncertain significance
Full SLC15A1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 87
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 69
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC15A1 p.Ala308Gly Uncertain significance Single submitter
- SLC15A1 p.Ala54Thr Uncertain significance Single submitter
- SLC15A1 p.Ala654Thr Uncertain significance Single submitter
- SLC15A1 p.Ala667Gly Uncertain significance Single submitter
- SLC15A1 p.Ala676Glu Uncertain significance Single submitter
- SLC15A1 p.Arg251Gln Uncertain significance Single submitter
- SLC15A1 p.Arg272Gln Uncertain significance Single submitter
- SLC15A1 p.Arg668Gln Uncertain significance Single submitter
- SLC15A1 p.Asn404Thr Uncertain significance Single submitter
- SLC15A1 p.Asn405Asp Uncertain significance Single submitter
- SLC15A1 p.Asn405Ser Uncertain significance Single submitter
- SLC15A1 p.Asn542His Uncertain significance Single submitter
- SLC15A1 p.Asn577Ser Uncertain significance Single submitter
- SLC15A1 p.Asp75Glu Uncertain significance Single submitter
- SLC15A1 p.Gln195Lys Uncertain significance Single submitter
- SLC15A1 p.Gln229His Uncertain significance Single submitter
- SLC15A1 p.Gln307Arg Uncertain significance Single submitter
- SLC15A1 p.Gln619Arg Uncertain significance Single submitter
- SLC15A1 p.Glu267Gly Uncertain significance Single submitter
- SLC15A1 p.Gly621Val Uncertain significance Single submitter
- SLC15A1 p.Gly70Arg Uncertain significance Single submitter
- SLC15A1 p.His250Arg Uncertain significance Single submitter
- SLC15A1 p.His460Asn Uncertain significance Single submitter
- SLC15A1 p.His460Leu Uncertain significance Single submitter
- SLC15A1 p.Ile45Thr Uncertain significance Single submitter
- SLC15A1 p.Ile93Thr Uncertain significance Single submitter
- SLC15A1 p.Leu168Phe Uncertain significance Single submitter
- SLC15A1 p.Leu175Phe Uncertain significance Single submitter
- SLC15A1 p.Lys157Arg Uncertain significance Single submitter
- SLC15A1 p.Lys483Asn Uncertain significance Single submitter
- SLC15A1 p.Met183Thr Uncertain significance Single submitter
- SLC15A1 p.Met209Val Uncertain significance Single submitter
- SLC15A1 p.Met336Thr Uncertain significance Single submitter
- SLC15A1 p.Met502Thr Uncertain significance Single submitter
- SLC15A1 p.Met581Val Uncertain significance Single submitter
- SLC15A1 p.Met614Ile Uncertain significance Single submitter
- SLC15A1 p.Met699Leu Uncertain significance Single submitter
- SLC15A1 p.Phe151Ser Uncertain significance Single submitter
- SLC15A1 p.Phe285Val Uncertain significance Single submitter
- SLC15A1 p.Phe605Ile Uncertain significance Single submitter
- SLC15A1 p.Phe682Ser Uncertain significance Single submitter
- SLC15A1 p.Pro115Arg Uncertain significance Single submitter
- SLC15A1 p.Pro182Ser Uncertain significance Single submitter
- SLC15A1 p.Pro322Ser Uncertain significance Single submitter
- SLC15A1 p.Pro338Leu Uncertain significance Single submitter
- SLC15A1 p.Pro467Ser Uncertain significance Single submitter
- SLC15A1 p.Ser193Ile Uncertain significance Single submitter
- SLC15A1 p.Ser302Phe Uncertain significance Single submitter
- SLC15A1 p.Ser511Arg Uncertain significance Single submitter
- SLC15A1 p.Ser512Asn Uncertain significance Single submitter
- SLC15A1 p.Ser616Leu Uncertain significance Single submitter
- SLC15A1 p.Ser88Thr Uncertain significance Single submitter
- SLC15A1 p.Thr178Ile Uncertain significance Single submitter
- SLC15A1 p.Thr305Ser Uncertain significance Single submitter
- SLC15A1 p.Thr406Ala Uncertain significance Single submitter
- SLC15A1 p.Thr424Arg Uncertain significance Single submitter
- SLC15A1 p.Thr429Ile Uncertain significance Single submitter
- SLC15A1 p.Thr545Ile Uncertain significance Single submitter
- SLC15A1 p.Tyr198Cys Uncertain significance Single submitter
- SLC15A1 p.Tyr40His Uncertain significance Single submitter
- SLC15A1 p.Tyr56Cys Uncertain significance Single submitter
- SLC15A1 p.Tyr697His Uncertain significance Single submitter
- SLC15A1 p.Val120Leu Uncertain significance Single submitter
- SLC15A1 p.Val20Met Uncertain significance Single submitter
- SLC15A1 p.Val328Met Uncertain significance Single submitter
- SLC15A1 p.Val334Met Uncertain significance Single submitter
- SLC15A1 p.Val363Phe Uncertain significance Single submitter
- SLC15A1 p.Val596Glu Uncertain significance Single submitter
- SLC15A1 p.Val633Met Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- SLC15A1 p.Asp112His Uncertain significance Single submitter
- SLC15A1 p.Asp116Asn Likely benign Single submitter
- SLC15A1 p.Asp116His Uncertain significance Single submitter
- SLC15A1 p.Cys539Arg Uncertain significance Single submitter
- SLC15A1 p.Gln609Glu Uncertain significance Single submitter
- SLC15A1 p.Gly11Ala Uncertain significance Single submitter
- SLC15A1 p.Gly234Asp Uncertain significance Single submitter
- SLC15A1 p.Gly524Asp Uncertain significance Single submitter
- SLC15A1 p.Gly551Ser Uncertain significance Single submitter
- SLC15A1 p.Leu435Gln Uncertain significance Single submitter
- SLC15A1 p.Met361Ile Uncertain significance Single submitter
- SLC15A1 p.Phe528Leu Uncertain significance Single submitter
- SLC15A1 p.Pro228Leu Uncertain significance Single submitter
- SLC15A1 p.Ser442Pro Uncertain significance Single submitter
- SLC15A1 p.Ser76Leu Uncertain significance Single submitter
- SLC15A1 p.Thr53Ile Uncertain significance Single submitter
- SLC15A1 p.Val378Met Uncertain significance Single submitter
- SLC15A1 p.Val626Met Uncertain significance Single submitter
All SLC15A1 variants
Benign 5
- p.Asn393= Multiple submitters
- p.Glu482= Multiple submitters
- p.Ser86= Multiple submitters
- p.Val122Met Multiple submitters
- c.1150-10T>C Single submitter
Likely benign 8
- p.Ala237Val Single submitter
- p.Asp116Asn Single submitter ⚠
- p.Ile525Val Single submitter
- p.Met183Ile Single submitter
- p.Met415Thr Single submitter
- p.Ser700Leu Single submitter
- p.Ser8Gly Single submitter
- p.Thr281Met Single submitter
Uncertain significance 90
- p.Ala308Gly Single submitter ⚠
- p.Ala54Thr Single submitter ⚠
- p.Ala654Thr Single submitter ⚠
- p.Ala667Gly Single submitter ⚠
- p.Ala676Glu Single submitter ⚠
- p.Arg251Gln Single submitter ⚠
- p.Arg272Gln Single submitter ⚠
- p.Arg668Gln Single submitter ⚠
- p.Asn404Thr Single submitter ⚠
- p.Asn405Asp Single submitter ⚠
- p.Asn405Ser Single submitter ⚠
- p.Asn542His Single submitter ⚠
- p.Asn577Ser Single submitter ⚠
- p.Asp112His Single submitter ⚠
- p.Asp116His Single submitter ⚠
- p.Asp75Glu Single submitter ⚠
- p.Cys539Arg Single submitter ⚠
- p.Gln195Lys Single submitter ⚠
- p.Gln229His Single submitter ⚠
- p.Gln307Arg Single submitter ⚠
- p.Gln609Glu Single submitter ⚠
- p.Gln619Arg Single submitter ⚠
- p.Glu267Gly Single submitter ⚠
- p.Gly11Ala Single submitter ⚠
- p.Gly234Asp Single submitter ⚠
- p.Gly524Asp Single submitter ⚠
- p.Gly551Ser Single submitter ⚠
- p.Gly621Val Single submitter ⚠
- p.Gly70Arg Single submitter ⚠
- p.His250Arg Single submitter ⚠
- p.His460Asn Single submitter ⚠
- p.His460Leu Single submitter ⚠
- p.Ile45Thr Single submitter ⚠
- p.Ile93Thr Single submitter ⚠
- p.Leu168Phe Single submitter ⚠
- p.Leu175Phe Single submitter ⚠
- p.Leu435Gln Single submitter ⚠
- p.Leu655Phe Single submitter
- p.Lys157Arg Single submitter ⚠
- p.Lys483Asn Single submitter ⚠
- p.Met183Thr Single submitter ⚠
- p.Met209Val Single submitter ⚠
- p.Met336Thr Single submitter ⚠
- p.Met361Ile Single submitter ⚠
- p.Met361Val Single submitter
- p.Met365Val Single submitter
- p.Met502Thr Single submitter ⚠
- p.Met581Val Single submitter ⚠
- p.Met614Ile Single submitter ⚠
- p.Met699Leu Single submitter ⚠
- p.Phe151Ser Single submitter ⚠
- p.Phe285Val Single submitter ⚠
- p.Phe528Leu Single submitter ⚠
- p.Phe605Ile Single submitter ⚠
- p.Phe682Ser Single submitter ⚠
- p.Pro115Arg Single submitter ⚠
- p.Pro182Ser Single submitter ⚠
- p.Pro228Leu Single submitter ⚠
- p.Pro322Ser Single submitter ⚠
- p.Pro338Leu Single submitter ⚠
- p.Pro467Ser Single submitter ⚠
- p.Ser15Asn Single submitter
- p.Ser193Ile Single submitter ⚠
- p.Ser302Phe Single submitter ⚠
- p.Ser442Pro Single submitter ⚠
- p.Ser511Arg Single submitter ⚠
- p.Ser512Asn Single submitter ⚠
- p.Ser616Leu Single submitter ⚠
- p.Ser76Leu Single submitter ⚠
- p.Ser88Thr Single submitter ⚠
- p.Thr178Ile Single submitter ⚠
- p.Thr305Ser Single submitter ⚠
- p.Thr406Ala Single submitter ⚠
- p.Thr424Arg Single submitter ⚠
- p.Thr429Ile Single submitter ⚠
- p.Thr53Ile Single submitter ⚠
- p.Thr545Ile Single submitter ⚠
- p.Tyr198Cys Single submitter ⚠
- p.Tyr40His Single submitter ⚠
- p.Tyr56Cys Single submitter ⚠
- p.Tyr697His Single submitter ⚠
- p.Val120Leu Single submitter ⚠
- p.Val20Met Single submitter ⚠
- p.Val328Met Single submitter ⚠
- p.Val334Met Single submitter ⚠
- p.Val363Phe Single submitter ⚠
- p.Val378Met Single submitter ⚠
- p.Val596Glu Single submitter ⚠
- p.Val626Met Single submitter ⚠
- p.Val633Met Single submitter ⚠