SLC15A2 — 100 ClinVar variants

All ClinVar germline SLC15A2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 86 flagged for review →

1 Benign · 5 Likely benign · 94 Uncertain significance

Full SLC15A2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 86

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 70

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 16

The independent predictors disagree with each other — read with care.

All SLC15A2 variants

Benign 1

p.Ser445= Multiple submitters

Likely benign 5

p.Ala609Val Single submitter
p.Arg705Gln Single submitter
p.Asn433Asp Single submitter
p.Met704Ile Single submitter
p.Thr511= Single submitter

Uncertain significance 94

p.Ala47Gly Single submitter ⚠
p.Arg25Pro Single submitter ⚠
p.Arg277Gln Single submitter ⚠
p.Arg322Gln Single submitter ⚠
p.Arg329Ser Single submitter ⚠
p.Asn538Asp Single submitter ⚠
p.Asn604Lys Single submitter ⚠
p.Asp360Asn Single submitter ⚠
p.Asp424Asn Single submitter ⚠
p.Asp542Gly Single submitter ⚠
p.Cys216Phe Single submitter ⚠
p.Cys258Tyr Single submitter ⚠
p.Cys38Arg Single submitter ⚠
p.Gln345Glu Single submitter ⚠
p.Gln594Arg Single submitter ⚠
p.Gln5Arg Single submitter ⚠
p.Gln636Glu Single submitter ⚠
p.Gly149Asp Single submitter ⚠
p.Gly149Ser Single submitter ⚠
p.Gly159Ser Single submitter ⚠
p.Gly225Val Single submitter
p.Gly320Asp Single submitter ⚠
p.Gly706Asp Single submitter ⚠
p.His142Arg Single submitter ⚠
p.His465Arg Single submitter ⚠
p.His479Pro Single submitter ⚠
p.Ile251Thr Single submitter ⚠
p.Ile251Val Single submitter ⚠
p.Ile293Thr Single submitter
p.Ile363Val Single submitter ⚠
p.Ile37Val Single submitter ⚠
p.Ile46Thr Single submitter
p.Ile491Thr Single submitter ⚠
p.Ile529Phe Single submitter ⚠
p.Ile653Thr Single submitter ⚠
p.Leu13Pro Single submitter ⚠
p.Leu227His Single submitter ⚠
p.Leu316Val Single submitter ⚠
p.Leu473Phe Single submitter ⚠
p.Leu523Ser Single submitter ⚠
p.Leu729Phe Single submitter ⚠
p.Lys175Asn Single submitter ⚠
p.Lys257Arg Single submitter ⚠
p.Lys290Arg Single submitter ⚠
p.Lys32Arg Single submitter ⚠
p.Lys448Glu Single submitter ⚠
p.Lys504Asn Single submitter ⚠
p.Lys605Asn Single submitter ⚠
p.Lys6Gln Single submitter ⚠
p.Met344Thr Single submitter
p.Met624Val Single submitter ⚠
p.Met63Thr Single submitter ⚠
p.Met719Lys Single submitter ⚠
p.Phe111Leu Single submitter ⚠
p.Phe221Leu Single submitter ⚠
p.Phe261Leu Single submitter ⚠
p.Phe336Ser Single submitter ⚠
p.Phe355Leu Single submitter ⚠
p.Phe374Ser Single submitter
p.Phe577Val Single submitter ⚠
p.Phe58Ser Single submitter ⚠
p.Phe675Ser Single submitter ⚠
p.Phe74Ile Single submitter ⚠
p.Pro24Leu Single submitter ⚠
p.Pro357Leu Single submitter ⚠
p.Pro35Leu Single submitter ⚠
p.Pro411Leu Single submitter ⚠
p.Pro450Ser Single submitter ⚠
p.Pro97Ser Single submitter ⚠
p.Ser106Leu Single submitter ⚠
p.Ser195Asn Single submitter ⚠
p.Ser375Pro Single submitter ⚠
p.Ser639Thr Single submitter ⚠
p.Ser640Thr Single submitter ⚠
p.Ser82Pro Single submitter ⚠
p.Thr300Pro Single submitter ⚠
p.Thr619Ala Single submitter ⚠
p.Thr652Ala Single submitter ⚠
p.Thr727Arg Single submitter ⚠
p.Trp280Cys Single submitter ⚠
p.Trp672Arg Single submitter ⚠
p.Tyr121Cys Single submitter ⚠
p.Tyr183His Single submitter ⚠
p.Tyr42Cys Single submitter
p.Tyr543Cys Single submitter ⚠
p.Val122Met Single submitter ⚠
p.Val229Ala Single submitter ⚠
p.Val252Gly Single submitter ⚠
p.Val382Ala Single submitter ⚠
p.Val50Leu Single submitter ⚠
p.Val660Leu Single submitter
p.Val660Met Single submitter
p.Val662Ala Single submitter ⚠
p.Val684Leu Single submitter ⚠