SLC16A7 — 74 ClinVar variants
All ClinVar germline SLC16A7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
2 Benign · 4 Likely benign · 68 Uncertain significance
Full SLC16A7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC16A7 p.Ala162Pro Uncertain significance Single submitter
- SLC16A7 p.Ala263Asp Uncertain significance Single submitter
- SLC16A7 p.Ala412Thr Uncertain significance Single submitter
- SLC16A7 p.Ala433Thr Uncertain significance Single submitter
- SLC16A7 p.Arg196Gly Uncertain significance Single submitter
- SLC16A7 p.Arg312Gln Uncertain significance Single submitter
- SLC16A7 p.Arg370Lys Uncertain significance Single submitter
- SLC16A7 p.Arg430Lys Uncertain significance Single submitter
- SLC16A7 p.Arg86Trp Uncertain significance Single submitter
- SLC16A7 p.Asn165Ser Uncertain significance Single submitter
- SLC16A7 p.Asn209Ser Uncertain significance Single submitter
- SLC16A7 p.Asn428Lys Uncertain significance Single submitter
- SLC16A7 p.Asn461Thr Uncertain significance Single submitter
- SLC16A7 p.Asp238Gly Uncertain significance Single submitter
- SLC16A7 p.Glu473Lys Uncertain significance Single submitter
- SLC16A7 p.Gly123Val Uncertain significance Single submitter
- SLC16A7 p.Gly411Trp Uncertain significance Single submitter
- SLC16A7 p.His456Asp Uncertain significance Single submitter
- SLC16A7 p.Ile380Leu Uncertain significance Single submitter
- SLC16A7 p.Ile427Val Uncertain significance Single submitter
- SLC16A7 p.Ile50Val Uncertain significance Single submitter
- SLC16A7 p.Leu168Pro Uncertain significance Single submitter
- SLC16A7 p.Leu181Trp Uncertain significance Single submitter
- SLC16A7 p.Leu268Phe Uncertain significance Single submitter
- SLC16A7 p.Leu302Phe Uncertain significance Single submitter
- SLC16A7 p.Leu388Pro Uncertain significance Single submitter
- SLC16A7 p.Leu79Ser Uncertain significance Single submitter
- SLC16A7 p.Lys221Glu Uncertain significance Single submitter
- SLC16A7 p.Met145Val Uncertain significance Single submitter
- SLC16A7 p.Pro130Arg Uncertain significance Single submitter
- SLC16A7 p.Pro144Leu Uncertain significance Single submitter
- SLC16A7 p.Pro369Ser Uncertain significance Single submitter
- SLC16A7 p.Ser205Pro Uncertain significance Single submitter
- SLC16A7 p.Ser281Thr Uncertain significance Single submitter
- SLC16A7 p.Ser299Phe Uncertain significance Single submitter
- SLC16A7 p.Ser299Thr Uncertain significance Single submitter
- SLC16A7 p.Ser418Arg Uncertain significance Single submitter
- SLC16A7 p.Ser454Tyr Uncertain significance Single submitter
- SLC16A7 p.Ser465Ala Uncertain significance Single submitter
- SLC16A7 p.Thr214Ala Uncertain significance Single submitter
- SLC16A7 p.Thr225Met Uncertain significance Single submitter
- SLC16A7 p.Tyr140Cys Uncertain significance Single submitter
- SLC16A7 p.Tyr337His Uncertain significance Single submitter
- SLC16A7 p.Tyr34Cys Uncertain significance Single submitter
- SLC16A7 p.Tyr403Cys Uncertain significance Single submitter
- SLC16A7 p.Val101Leu Uncertain significance Single submitter
- SLC16A7 p.Val101Met Uncertain significance Single submitter
- SLC16A7 p.Val345Glu Uncertain significance Single submitter
- SLC16A7 p.Val375Ile Uncertain significance Single submitter
- SLC16A7 p.Val419Ala Uncertain significance Single submitter
- SLC16A7 p.Val470Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- SLC16A7 p.Arg310Gln Uncertain significance Single submitter
- SLC16A7 p.Arg86Gln Uncertain significance Single submitter
- SLC16A7 p.Gln314Arg Uncertain significance Single submitter
- SLC16A7 p.Gly367Ser Uncertain significance Single submitter
- SLC16A7 p.Gly84Ser Uncertain significance Single submitter
- SLC16A7 p.Ile423Thr Uncertain significance Single submitter
- SLC16A7 p.Leu286Val Uncertain significance Single submitter
- SLC16A7 p.Met100Thr Uncertain significance Single submitter
- SLC16A7 p.Phe126Leu Uncertain significance Single submitter
- SLC16A7 p.Phe261Leu Uncertain significance Single submitter
- SLC16A7 p.Pro14Ala Uncertain significance Single submitter
- SLC16A7 p.Ser339Arg Uncertain significance Single submitter
- SLC16A7 p.Ser353Asn Uncertain significance Single submitter
All SLC16A7 variants
Benign 2
- p.Ala35= Multiple submitters
- p.Asn201Ser Multiple submitters
Likely benign 4
- p.Asn170= Single submitter
- p.Gln111Glu Single submitter
- p.Ile380Val Single submitter
- p.Leu185Phe Single submitter
Uncertain significance 68
- p.Ala162Pro Single submitter ⚠
- p.Ala263Asp Single submitter ⚠
- p.Ala412Thr Single submitter ⚠
- p.Ala433Thr Single submitter ⚠
- p.Arg196Gly Single submitter ⚠
- p.Arg310Gln Single submitter ⚠
- p.Arg312Gln Single submitter ⚠
- p.Arg370Lys Single submitter ⚠
- p.Arg430Lys Single submitter ⚠
- p.Arg430Ser Single submitter
- p.Arg86Gln Single submitter ⚠
- p.Arg86Trp Single submitter ⚠
- p.Asn165Ser Single submitter ⚠
- p.Asn209Ser Single submitter ⚠
- p.Asn428Lys Single submitter ⚠
- p.Asn461Thr Single submitter ⚠
- p.Asp238Gly Single submitter ⚠
- p.Gln314Arg Single submitter ⚠
- p.Glu435Lys Single submitter
- p.Glu473Lys Single submitter ⚠
- p.Gly123Val Single submitter ⚠
- p.Gly367Ser Single submitter ⚠
- p.Gly411Trp Single submitter ⚠
- p.Gly84Ser Single submitter ⚠
- p.His456Asp Single submitter ⚠
- p.Ile380Leu Single submitter ⚠
- p.Ile423Thr Single submitter ⚠
- p.Ile427Val Single submitter ⚠
- p.Ile50Val Single submitter ⚠
- p.Leu168Pro Single submitter ⚠
- p.Leu181Trp Single submitter ⚠
- p.Leu268Phe Single submitter ⚠
- p.Leu286Val Single submitter ⚠
- p.Leu302Phe Single submitter ⚠
- p.Leu388Pro Single submitter ⚠
- p.Leu79Ser Single submitter ⚠
- p.Lys221Glu Single submitter ⚠
- p.Met100Thr Single submitter ⚠
- p.Met145Val Single submitter ⚠
- p.Phe105Ser Single submitter
- p.Phe126Leu Single submitter ⚠
- p.Phe261Leu Single submitter ⚠
- p.Pro130Arg Single submitter ⚠
- p.Pro144Leu Single submitter ⚠
- p.Pro14Ala Single submitter ⚠
- p.Pro369Ser Single submitter ⚠
- p.Ser205Pro Single submitter ⚠
- p.Ser281Thr Single submitter ⚠
- p.Ser299Phe Single submitter ⚠
- p.Ser299Thr Single submitter ⚠
- p.Ser339Arg Single submitter ⚠
- p.Ser353Asn Single submitter ⚠
- p.Ser418Arg Single submitter ⚠
- p.Ser454Tyr Single submitter ⚠
- p.Ser465Ala Single submitter ⚠
- p.Thr214Ala Single submitter ⚠
- p.Thr225Met Single submitter ⚠
- p.Tyr140Cys Single submitter ⚠
- p.Tyr337His Single submitter ⚠
- p.Tyr34Cys Single submitter ⚠
- p.Tyr403Cys Single submitter ⚠
- p.Val101Leu Single submitter ⚠
- p.Val101Met Single submitter ⚠
- p.Val190Met Single submitter
- p.Val345Glu Single submitter ⚠
- p.Val375Ile Single submitter ⚠
- p.Val419Ala Single submitter ⚠
- p.Val470Ile Single submitter ⚠