SLC16A8 — 104 ClinVar variants
All ClinVar germline SLC16A8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 94 flagged for review →
2 Benign · 4 Likely benign · 98 Uncertain significance
Full SLC16A8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 94
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC16A8 p.Ala124Gly Uncertain significance Single submitter
- SLC16A8 p.Ala124Pro Uncertain significance Single submitter
- SLC16A8 p.Ala159Val Uncertain significance Single submitter
- SLC16A8 p.Ala257Thr Uncertain significance Single submitter
- SLC16A8 p.Ala289Pro Uncertain significance Single submitter
- SLC16A8 p.Ala289Thr Uncertain significance Single submitter
- SLC16A8 p.Ala305Glu Uncertain significance Single submitter
- SLC16A8 p.Ala308Asp Uncertain significance Single submitter
- SLC16A8 p.Ala310Glu Uncertain significance Single submitter
- SLC16A8 p.Ala338Thr Uncertain significance Single submitter
- SLC16A8 p.Ala440Val Uncertain significance Single submitter
- SLC16A8 p.Ala500Pro Uncertain significance Single submitter
- SLC16A8 p.Ala52Thr Uncertain significance Single submitter
- SLC16A8 p.Ala52Val Uncertain significance Single submitter
- SLC16A8 p.Ala97Val Uncertain significance Single submitter
- SLC16A8 p.Arg142Gln Uncertain significance Single submitter
- SLC16A8 p.Arg303Gly Uncertain significance Single submitter
- SLC16A8 p.Arg339His Uncertain significance Single submitter
- SLC16A8 p.Arg401His Uncertain significance Single submitter
- SLC16A8 p.Arg436Cys Uncertain significance Single submitter
- SLC16A8 p.Arg485Gln Uncertain significance Single submitter
- SLC16A8 p.Arg7Pro Uncertain significance Single submitter
- SLC16A8 p.Arg7Trp Uncertain significance Single submitter
- SLC16A8 p.Asn126Lys Uncertain significance Single submitter
- SLC16A8 p.Asp14Asn Uncertain significance Single submitter
- SLC16A8 p.Asp250Asn Uncertain significance Single submitter
- SLC16A8 p.Asp456Glu Uncertain significance Single submitter
- SLC16A8 p.Cys306Arg Uncertain significance Single submitter
- SLC16A8 p.Cys84Tyr Uncertain significance Single submitter
- SLC16A8 p.Gln166Leu Uncertain significance Single submitter
- SLC16A8 p.Glu219Lys Uncertain significance Single submitter
- SLC16A8 p.Glu410Lys Uncertain significance Single submitter
- SLC16A8 p.Gly15Asp Uncertain significance Single submitter
- SLC16A8 p.Gly214Arg Uncertain significance Single submitter
- SLC16A8 p.Gly218Asp Uncertain significance Single submitter
- SLC16A8 p.Gly266Arg Uncertain significance Single submitter
- SLC16A8 p.Gly373Arg Uncertain significance Single submitter
- SLC16A8 p.Gly450Arg Uncertain significance Single submitter
- SLC16A8 p.Gly53Ala Uncertain significance Single submitter
- SLC16A8 p.Gly53Ser Uncertain significance Single submitter
- SLC16A8 p.Gly92Glu Uncertain significance Single submitter
- SLC16A8 p.Ile294Val Uncertain significance Single submitter
- SLC16A8 p.Ile394Met Uncertain significance Single submitter
- SLC16A8 p.Ile412Leu Uncertain significance Single submitter
- SLC16A8 p.Leu125Phe Uncertain significance Single submitter
- SLC16A8 p.Leu309Pro Uncertain significance Single submitter
- SLC16A8 p.Leu355Phe Uncertain significance Single submitter
- SLC16A8 p.Leu363Pro Uncertain significance Single submitter
- SLC16A8 p.Leu402Val Uncertain significance Single submitter
- SLC16A8 p.Met359Thr Uncertain significance Single submitter
- SLC16A8 p.Met359Val Uncertain significance Single submitter
- SLC16A8 p.Pro129Ser Uncertain significance Single submitter
- SLC16A8 p.Pro234Leu Uncertain significance Single submitter
- SLC16A8 p.Pro238Ser Uncertain significance Single submitter
- SLC16A8 p.Pro375Thr Uncertain significance Single submitter
- SLC16A8 p.Pro397Ser Uncertain significance Single submitter
- SLC16A8 p.Pro442Leu Uncertain significance Single submitter
- SLC16A8 p.Pro445Ser Uncertain significance Single submitter
- SLC16A8 p.Pro488Ser Uncertain significance Single submitter
- SLC16A8 p.Pro497Leu Uncertain significance Single submitter
- SLC16A8 p.Ser337Gly Uncertain significance Single submitter
- SLC16A8 p.Ser483Arg Uncertain significance Single submitter
- SLC16A8 p.Ser55Gly Uncertain significance Single submitter
- SLC16A8 p.Thr286Ile Uncertain significance Single submitter
- SLC16A8 p.Thr286Ser Uncertain significance Single submitter
- SLC16A8 p.Tyr357Phe Uncertain significance Single submitter
- SLC16A8 p.Val193Ile Uncertain significance Single submitter
- SLC16A8 p.Val20Met Uncertain significance Single submitter
- SLC16A8 p.Val27Ala Uncertain significance Single submitter
- SLC16A8 p.Val27Met Uncertain significance Single submitter
- SLC16A8 p.Val295Ala Uncertain significance Single submitter
- SLC16A8 p.Val298Leu Uncertain significance Single submitter
- SLC16A8 p.Val301Ala Uncertain significance Single submitter
- SLC16A8 p.Val39Leu Uncertain significance Single submitter
- SLC16A8 p.Ile132Met Uncertain significance No assertion criteria
Predictors split 19
The independent predictors disagree with each other — read with care.
- SLC16A8 p.Ala189Thr Uncertain significance Single submitter
- SLC16A8 p.Ala362Thr Uncertain significance Single submitter
- SLC16A8 p.Ala399Thr Uncertain significance Single submitter
- SLC16A8 p.Ala52Asp Uncertain significance Single submitter
- SLC16A8 p.Arg141Gln Uncertain significance Single submitter
- SLC16A8 p.Arg316Gln Uncertain significance Single submitter
- SLC16A8 p.Arg376Leu Uncertain significance Single submitter
- SLC16A8 p.Arg401Cys Uncertain significance Single submitter
- SLC16A8 p.Gly23Asp Uncertain significance Single submitter
- SLC16A8 p.Ile412Ser Uncertain significance Single submitter
- SLC16A8 p.Leu267Val Uncertain significance Single submitter
- SLC16A8 p.Leu332Phe Uncertain significance Single submitter
- SLC16A8 p.Leu385Val Uncertain significance Single submitter
- SLC16A8 p.Leu393Phe Uncertain significance Single submitter
- SLC16A8 p.Leu393Val Uncertain significance Single submitter
- SLC16A8 p.Met369Val Uncertain significance Single submitter
- SLC16A8 p.Phe297Leu Uncertain significance Single submitter
- SLC16A8 p.Ser337Arg Uncertain significance Single submitter
- SLC16A8 p.Val367Met Uncertain significance Single submitter
All SLC16A8 variants
Benign 2
- p.Glu502Lys Single submitter
- p.Ser483fs Single submitter
Likely benign 4
- p.Ala501= Single submitter
- p.Ile493Thr Single submitter
- p.Leu227Pro Single submitter
- p.Val387Leu Single submitter
Uncertain significance 98
- p.Ala124Gly Single submitter ⚠
- p.Ala124Pro Single submitter ⚠
- p.Ala159Val Single submitter ⚠
- p.Ala189Thr Single submitter ⚠
- p.Ala257Thr Single submitter ⚠
- p.Ala289Pro Single submitter ⚠
- p.Ala289Thr Single submitter ⚠
- p.Ala305Glu Single submitter ⚠
- p.Ala308Asp Single submitter ⚠
- p.Ala310Glu Single submitter ⚠
- p.Ala338Thr Single submitter ⚠
- p.Ala362Thr Single submitter ⚠
- p.Ala399Thr Single submitter ⚠
- p.Ala440Val Single submitter ⚠
- p.Ala500Pro Single submitter ⚠
- p.Ala52Asp Single submitter ⚠
- p.Ala52Thr Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Ala97Val Single submitter ⚠
- p.Arg141Gln Single submitter ⚠
- p.Arg142Gln Single submitter ⚠
- p.Arg303Gly Single submitter ⚠
- p.Arg316Gln Single submitter ⚠
- p.Arg339His Single submitter ⚠
- p.Arg376Leu Single submitter ⚠
- p.Arg401Cys Single submitter ⚠
- p.Arg401His Single submitter ⚠
- p.Arg436Cys Single submitter ⚠
- p.Arg485Gln Single submitter ⚠
- p.Arg7Pro Single submitter ⚠
- p.Arg7Trp Single submitter ⚠
- p.Asn126Lys Single submitter ⚠
- p.Asp14Asn Single submitter ⚠
- p.Asp244His Single submitter
- p.Asp250Asn Single submitter ⚠
- p.Asp456Glu Single submitter ⚠
- p.Cys306Arg Single submitter ⚠
- p.Cys84Tyr Single submitter ⚠
- p.Gln166Leu Single submitter ⚠
- p.Glu219Lys Single submitter ⚠
- p.Glu410Lys Single submitter ⚠
- p.Gly15Asp Single submitter ⚠
- p.Gly214Arg Single submitter ⚠
- p.Gly218Asp Single submitter ⚠
- p.Gly23Asp Single submitter ⚠
- p.Gly266Arg Single submitter ⚠
- p.Gly373Arg Single submitter ⚠
- p.Gly450Arg Single submitter ⚠
- p.Gly53Ala Single submitter ⚠
- p.Gly53Ser Single submitter ⚠
- p.Gly92Glu Single submitter ⚠
- p.Ile294Val Single submitter ⚠
- p.Ile394Met Single submitter ⚠
- p.Ile412Leu Single submitter ⚠
- p.Ile412Ser Single submitter ⚠
- p.Leu125Phe Single submitter ⚠
- p.Leu267Val Single submitter ⚠
- p.Leu309Pro Single submitter ⚠
- p.Leu332Phe Single submitter ⚠
- p.Leu346Phe Single submitter
- p.Leu355Phe Single submitter ⚠
- p.Leu363Pro Single submitter ⚠
- p.Leu385Val Single submitter ⚠
- p.Leu393Phe Single submitter ⚠
- p.Leu393Val Single submitter ⚠
- p.Leu402Val Single submitter ⚠
- p.Met359Thr Single submitter ⚠
- p.Met359Val Single submitter ⚠
- p.Met369Val Single submitter ⚠
- p.Phe297Leu Single submitter ⚠
- p.Pro129Ser Single submitter ⚠
- p.Pro234Leu Single submitter ⚠
- p.Pro238Ser Single submitter ⚠
- p.Pro375Thr Single submitter ⚠
- p.Pro397Ser Single submitter ⚠
- p.Pro442Leu Single submitter ⚠
- p.Pro445Ser Single submitter ⚠
- p.Pro488Ser Single submitter ⚠
- p.Pro497Leu Single submitter ⚠
- p.Ser337Arg Single submitter ⚠
- p.Ser337Gly Single submitter ⚠
- p.Ser483Arg Single submitter ⚠
- p.Ser55Gly Single submitter ⚠
- p.Thr286Ile Single submitter ⚠
- p.Thr286Ser Single submitter ⚠
- p.Thr80Ile Single submitter
- p.Tyr357Phe Single submitter ⚠
- p.Val193Ile Single submitter ⚠
- p.Val20Met Single submitter ⚠
- p.Val27Ala Single submitter ⚠
- p.Val27Met Single submitter ⚠
- p.Val295Ala Single submitter ⚠
- p.Val298Leu Single submitter ⚠
- p.Val298Met Single submitter
- p.Val301Ala Single submitter ⚠
- p.Val367Met Single submitter ⚠
- p.Val39Leu Single submitter ⚠
- p.Ile132Met No assertion criteria ⚠