SLC18A1 — 107 ClinVar variants
All ClinVar germline SLC18A1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 99 flagged for review →
4 Likely benign · 103 Uncertain significance
Full SLC18A1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 99
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC18A1 p.Ala185Pro Uncertain significance Single submitter
- SLC18A1 p.Ala18Thr Uncertain significance Single submitter
- SLC18A1 p.Ala30Thr Uncertain significance Single submitter
- SLC18A1 p.Ala345Ser Uncertain significance Single submitter
- SLC18A1 p.Ala360Gly Uncertain significance Single submitter
- SLC18A1 p.Ala450Val Uncertain significance Single submitter
- SLC18A1 p.Ala483Thr Uncertain significance Single submitter
- SLC18A1 p.Arg197Gln Uncertain significance Single submitter
- SLC18A1 p.Arg20Gln Uncertain significance Single submitter
- SLC18A1 p.Arg421Cys Uncertain significance Single submitter
- SLC18A1 p.Asn154Lys Uncertain significance Single submitter
- SLC18A1 p.Asn162Lys Uncertain significance Single submitter
- SLC18A1 p.Asn35Asp Uncertain significance Single submitter
- SLC18A1 p.Asn361Ser Uncertain significance Single submitter
- SLC18A1 p.Asn388Ser Uncertain significance Single submitter
- SLC18A1 p.Asn396Ser Uncertain significance Single submitter
- SLC18A1 p.Asp518His Uncertain significance Single submitter
- SLC18A1 p.Glu135Asp Uncertain significance Single submitter
- SLC18A1 p.Glu224Gln Uncertain significance Single submitter
- SLC18A1 p.Glu485Asp Uncertain significance Single submitter
- SLC18A1 p.Glu520Gly Uncertain significance Single submitter
- SLC18A1 p.Glu53Gln Uncertain significance Single submitter
- SLC18A1 p.Gly140Glu Uncertain significance Single submitter
- SLC18A1 p.Gly16Ala Uncertain significance Single submitter
- SLC18A1 p.Gly188Glu Uncertain significance Single submitter
- SLC18A1 p.Gly203Glu Uncertain significance Single submitter
- SLC18A1 p.Gly364Cys Uncertain significance Single submitter
- SLC18A1 p.Gly456Val Uncertain significance Single submitter
- SLC18A1 p.Gly514Arg Uncertain significance Single submitter
- SLC18A1 p.Gly64Ser Uncertain significance Single submitter
- SLC18A1 p.His223Arg Uncertain significance Single submitter
- SLC18A1 p.His422Gln Uncertain significance Single submitter
- SLC18A1 p.His71Gln Uncertain significance Single submitter
- SLC18A1 p.Ile176Phe Uncertain significance Single submitter
- SLC18A1 p.Ile202Met Uncertain significance Single submitter
- SLC18A1 p.Ile202Thr Uncertain significance Single submitter
- SLC18A1 p.Ile202Val Uncertain significance Single submitter
- SLC18A1 p.Ile403Val Uncertain significance Single submitter
- SLC18A1 p.Ile432Val Uncertain significance Single submitter
- SLC18A1 p.Ile469Phe Uncertain significance Single submitter
- SLC18A1 p.Leu132Phe Uncertain significance Single submitter
- SLC18A1 p.Leu151Phe Uncertain significance Single submitter
- SLC18A1 p.Leu179Phe Uncertain significance Single submitter
- SLC18A1 p.Leu193Arg Uncertain significance Single submitter
- SLC18A1 p.Leu278Val Uncertain significance Single submitter
- SLC18A1 p.Leu359Met Uncertain significance Single submitter
- SLC18A1 p.Leu399Val Uncertain significance Single submitter
- SLC18A1 p.Leu63Val Uncertain significance Single submitter
- SLC18A1 p.Met149Thr Uncertain significance Single submitter
- SLC18A1 p.Met170Thr Uncertain significance Single submitter
- SLC18A1 p.Met214Thr Uncertain significance Single submitter
- SLC18A1 p.Met414Leu Uncertain significance Single submitter
- SLC18A1 p.Phe390Leu Uncertain significance Single submitter
- SLC18A1 p.Phe82Cys Uncertain significance Single submitter
- SLC18A1 p.Pro112Arg Uncertain significance Single submitter
- SLC18A1 p.Pro169Ser Uncertain significance Single submitter
- SLC18A1 p.Pro259Arg Uncertain significance Single submitter
- SLC18A1 p.Pro280His Uncertain significance Single submitter
- SLC18A1 p.Pro384Leu Uncertain significance Single submitter
- SLC18A1 p.Pro482Ala Uncertain significance Single submitter
- SLC18A1 p.Ser19Pro Uncertain significance Single submitter
- SLC18A1 p.Ser248Gly Uncertain significance Single submitter
- SLC18A1 p.Ser281Thr Uncertain significance Single submitter
- SLC18A1 p.Ser480Asn Uncertain significance Single submitter
- SLC18A1 p.Ser492Arg Uncertain significance Single submitter
- SLC18A1 p.Thr109Ile Uncertain significance Single submitter
- SLC18A1 p.Thr129Pro Uncertain significance Single submitter
- SLC18A1 p.Thr499Asn Uncertain significance Single submitter
- SLC18A1 p.Thr499Ser Uncertain significance Single submitter
- SLC18A1 p.Val153Ile Uncertain significance Single submitter
- SLC18A1 p.Val254Ala Uncertain significance Single submitter
- SLC18A1 p.Val466Phe Uncertain significance Single submitter
- SLC18A1 p.Val470Ala Uncertain significance Single submitter
- SLC18A1 p.Val96Ile Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- SLC18A1 p.Ala144Thr Uncertain significance Single submitter
- SLC18A1 p.Ala433Thr Uncertain significance Single submitter
- SLC18A1 p.Arg365Trp Uncertain significance Single submitter
- SLC18A1 p.Arg421His Uncertain significance Single submitter
- SLC18A1 p.Asn162Ser Uncertain significance Single submitter
- SLC18A1 p.Asn396Thr Uncertain significance Single submitter
- SLC18A1 p.Asp222Ala Uncertain significance Single submitter
- SLC18A1 p.Asp222Asn Uncertain significance Single submitter
- SLC18A1 p.Gly449Cys Uncertain significance Single submitter
- SLC18A1 p.Gly456Ser Uncertain significance Single submitter
- SLC18A1 p.Leu350Phe Uncertain significance Single submitter
- SLC18A1 p.Lys362Glu Uncertain significance Single submitter
- SLC18A1 p.Met170Val Uncertain significance Single submitter
- SLC18A1 p.Met229Val Uncertain significance Single submitter
- SLC18A1 p.Met411Ile Uncertain significance Single submitter
- SLC18A1 p.Phe441Ser Uncertain significance Single submitter
- SLC18A1 p.Pro155Ala Uncertain significance Single submitter
- SLC18A1 p.Pro155Thr Uncertain significance Single submitter
- SLC18A1 p.Pro280Ala Uncertain significance Single submitter
- SLC18A1 p.Pro280Ser Uncertain significance Single submitter
- SLC18A1 p.Pro482Leu Uncertain significance Single submitter
- SLC18A1 p.Tyr471Cys Uncertain significance Single submitter
- SLC18A1 p.Tyr476His Uncertain significance Single submitter
- SLC18A1 p.Val157Met Uncertain significance Single submitter
- SLC18A1 p.Val452Gly Uncertain significance Single submitter
All SLC18A1 variants
Likely benign 4
- p.Ala74Thr Single submitter
- p.Leu491= Single submitter
- p.Ser95= Single submitter
- p.Val90Met Single submitter
Uncertain significance 103
- p.Ala144Thr Single submitter ⚠
- p.Ala185Pro Single submitter ⚠
- p.Ala18Thr Single submitter ⚠
- p.Ala30Thr Single submitter ⚠
- p.Ala345Ser Single submitter ⚠
- p.Ala360Gly Single submitter ⚠
- p.Ala433Thr Single submitter ⚠
- p.Ala450Val Single submitter ⚠
- p.Ala483Thr Single submitter ⚠
- p.Arg197Gln Single submitter ⚠
- p.Arg20Gln Single submitter ⚠
- p.Arg365Trp Single submitter ⚠
- p.Arg421Cys Single submitter ⚠
- p.Arg421His Single submitter ⚠
- p.Asn154Lys Single submitter ⚠
- p.Asn162Lys Single submitter ⚠
- p.Asn162Ser Single submitter ⚠
- p.Asn35Asp Single submitter ⚠
- p.Asn361Ser Single submitter ⚠
- p.Asn388Ser Single submitter ⚠
- p.Asn396Ser Single submitter ⚠
- p.Asn396Thr Single submitter ⚠
- p.Asp222Ala Single submitter ⚠
- p.Asp222Asn Single submitter ⚠
- p.Asp518His Single submitter ⚠
- p.Cys125Gly Single submitter
- p.Glu135Asp Single submitter ⚠
- p.Glu224Gln Single submitter ⚠
- p.Glu485Asp Single submitter ⚠
- p.Glu520Gly Single submitter ⚠
- p.Glu53Gln Single submitter ⚠
- p.Gly140Glu Single submitter ⚠
- p.Gly16Ala Single submitter ⚠
- p.Gly188Glu Single submitter ⚠
- p.Gly203Glu Single submitter ⚠
- p.Gly364Cys Single submitter ⚠
- p.Gly449Cys Single submitter ⚠
- p.Gly456Ser Single submitter ⚠
- p.Gly456Val Single submitter ⚠
- p.Gly514Arg Single submitter ⚠
- p.Gly64Ser Single submitter ⚠
- p.His223Arg Single submitter ⚠
- p.His422Gln Single submitter ⚠
- p.His71Gln Single submitter ⚠
- p.Ile176Phe Single submitter ⚠
- p.Ile202Met Single submitter ⚠
- p.Ile202Thr Single submitter ⚠
- p.Ile202Val Single submitter ⚠
- p.Ile403Val Single submitter ⚠
- p.Ile432Val Single submitter ⚠
- p.Ile469Phe Single submitter ⚠
- p.Leu132Phe Single submitter ⚠
- p.Leu151Phe Single submitter ⚠
- p.Leu179Phe Single submitter ⚠
- p.Leu193Arg Single submitter ⚠
- p.Leu278Val Single submitter ⚠
- p.Leu350Phe Single submitter ⚠
- p.Leu359Met Single submitter ⚠
- p.Leu399Val Single submitter ⚠
- p.Leu63Val Single submitter ⚠
- p.Lys362Glu Single submitter ⚠
- p.Met149Thr Single submitter ⚠
- p.Met170Thr Single submitter ⚠
- p.Met170Val Single submitter ⚠
- p.Met214Thr Single submitter ⚠
- p.Met229Val Single submitter ⚠
- p.Met411Ile Single submitter ⚠
- p.Met414Leu Single submitter ⚠
- p.Phe390Leu Single submitter ⚠
- p.Phe441Ser Single submitter ⚠
- p.Phe82Cys Single submitter ⚠
- p.Pro112Arg Single submitter ⚠
- p.Pro155Ala Single submitter ⚠
- p.Pro155Thr Single submitter ⚠
- p.Pro169Ser Single submitter ⚠
- p.Pro259Arg Single submitter ⚠
- p.Pro280Ala Single submitter ⚠
- p.Pro280His Single submitter ⚠
- p.Pro280Ser Single submitter ⚠
- p.Pro384Leu Single submitter ⚠
- p.Pro412Thr Single submitter
- p.Pro482Ala Single submitter ⚠
- p.Pro482Leu Single submitter ⚠
- p.Ser180Thr Single submitter
- p.Ser19Pro Single submitter ⚠
- p.Ser248Gly Single submitter ⚠
- p.Ser281Thr Single submitter ⚠
- p.Ser480Asn Single submitter ⚠
- p.Ser492Arg Single submitter ⚠
- p.Thr109Ile Single submitter ⚠
- p.Thr129Pro Single submitter ⚠
- p.Thr499Asn Single submitter ⚠
- p.Thr499Ser Single submitter ⚠
- p.Tyr471Cys Single submitter ⚠
- p.Tyr476His Single submitter ⚠
- p.Val153Ile Single submitter ⚠
- p.Val157Leu Single submitter
- p.Val157Met Single submitter ⚠
- p.Val254Ala Single submitter ⚠
- p.Val452Gly Single submitter ⚠
- p.Val466Phe Single submitter ⚠
- p.Val470Ala Single submitter ⚠
- p.Val96Ile Single submitter ⚠