SLC22A11 — 83 ClinVar variants
All ClinVar germline SLC22A11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
2 Benign · 7 Likely benign · 74 Uncertain significance
Full SLC22A11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC22A11 p.Ala181Ser Uncertain significance Single submitter
- SLC22A11 p.Ala183Thr Uncertain significance Single submitter
- SLC22A11 p.Ala240Thr Uncertain significance Single submitter
- SLC22A11 p.Ala243Val Uncertain significance Single submitter
- SLC22A11 p.Ala348Thr Uncertain significance Single submitter
- SLC22A11 p.Ala379Thr Uncertain significance Single submitter
- SLC22A11 p.Ala390Val Uncertain significance Single submitter
- SLC22A11 p.Arg121Leu Uncertain significance Single submitter
- SLC22A11 p.Arg200Trp Uncertain significance Single submitter
- SLC22A11 p.Arg331Leu Uncertain significance Single submitter
- SLC22A11 p.Arg372His Uncertain significance Single submitter
- SLC22A11 p.Arg430His Uncertain significance Single submitter
- SLC22A11 p.Arg539Trp Uncertain significance Single submitter
- SLC22A11 p.Asn99Ser Uncertain significance Single submitter
- SLC22A11 p.Asp522Asn Uncertain significance Single submitter
- SLC22A11 p.Cys197Tyr Uncertain significance Single submitter
- SLC22A11 p.Gln139Arg Uncertain significance Single submitter
- SLC22A11 p.Gln427His Uncertain significance Single submitter
- SLC22A11 p.Glu107Lys Uncertain significance Single submitter
- SLC22A11 p.Gly152Arg Uncertain significance Single submitter
- SLC22A11 p.Gly198Ser Uncertain significance Single submitter
- SLC22A11 p.Gly246Asp Uncertain significance Single submitter
- SLC22A11 p.Gly46Ser Uncertain significance Single submitter
- SLC22A11 p.Ile313Thr Uncertain significance Single submitter
- SLC22A11 p.Ile443Leu Uncertain significance Single submitter
- SLC22A11 p.Leu15Pro Uncertain significance Single submitter
- SLC22A11 p.Leu173Met Uncertain significance Single submitter
- SLC22A11 p.Leu29Phe Uncertain significance Single submitter
- SLC22A11 p.Leu377Phe Uncertain significance Single submitter
- SLC22A11 p.Leu426Trp Uncertain significance Single submitter
- SLC22A11 p.Met64Val Uncertain significance Single submitter
- SLC22A11 p.Pro171Leu Uncertain significance Single submitter
- SLC22A11 p.Pro340Ser Uncertain significance Single submitter
- SLC22A11 p.Ser147Pro Uncertain significance Single submitter
- SLC22A11 p.Ser239Arg Uncertain significance Single submitter
- SLC22A11 p.Ser359Phe Uncertain significance Single submitter
- SLC22A11 p.Ser529Arg Uncertain significance Single submitter
- SLC22A11 p.Ser532Leu Uncertain significance Single submitter
- SLC22A11 p.Ser547Ile Uncertain significance Single submitter
- SLC22A11 p.Ser549Leu Uncertain significance Single submitter
- SLC22A11 p.Thr110Met Uncertain significance Single submitter
- SLC22A11 p.Thr230Ser Uncertain significance Single submitter
- SLC22A11 p.Thr23Ile Uncertain significance Single submitter
- SLC22A11 p.Thr428Asn Uncertain significance Single submitter
- SLC22A11 p.Thr463Arg Uncertain significance Single submitter
- SLC22A11 p.Trp117Cys Uncertain significance Single submitter
- SLC22A11 p.Val123Ile Uncertain significance Single submitter
- SLC22A11 p.Val324Leu Uncertain significance Single submitter
- SLC22A11 p.Val499Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- SLC22A11 p.Ala240Pro Uncertain significance Single submitter
- SLC22A11 p.Ala280Thr Uncertain significance Single submitter
- SLC22A11 p.Ala43Thr Uncertain significance Single submitter
- SLC22A11 p.Arg281Trp Uncertain significance Single submitter
- SLC22A11 p.Arg402His Uncertain significance Single submitter
- SLC22A11 p.Arg486His Uncertain significance Single submitter
- SLC22A11 p.Arg86His Uncertain significance Single submitter
- SLC22A11 p.Asp526Tyr Uncertain significance Single submitter
- SLC22A11 p.Cys447Arg Uncertain significance Single submitter
- SLC22A11 p.Gln259His Uncertain significance Single submitter
- SLC22A11 p.Gln34Arg Uncertain significance Single submitter
- SLC22A11 p.Gly209Ser Uncertain significance Single submitter
- SLC22A11 p.Gly77Ser Uncertain significance Single submitter
- SLC22A11 p.Ile44Phe Uncertain significance Single submitter
- SLC22A11 p.Met478Arg Uncertain significance Single submitter
- SLC22A11 p.Phe189Ser Uncertain significance Single submitter
- SLC22A11 p.Phe337Leu Uncertain significance Single submitter
- SLC22A11 p.Pro519Leu Uncertain significance Single submitter
- SLC22A11 p.Pro82Thr Uncertain significance Single submitter
- SLC22A11 p.Ser332Trp Uncertain significance Single submitter
- SLC22A11 p.Thr101Met Uncertain significance Single submitter
- SLC22A11 p.Trp160Arg Uncertain significance Single submitter
All SLC22A11 variants
Likely benign 7
- p.Arg121His Single submitter
- p.Arg48Ter Single submitter
- p.Gly57Ser Single submitter
- p.Ile450Val Single submitter
- p.Ala183= No assertion criteria SLC22A11-related disorder
- p.Ala2Val No assertion criteria SLC22A11-related disorder
- p.Arg343Leu No assertion criteria SLC22A11-related disorder
Uncertain significance 74
- p.Ala181Ser Single submitter ⚠
- p.Ala183Thr Single submitter ⚠
- p.Ala240Pro Single submitter ⚠
- p.Ala240Thr Single submitter ⚠
- p.Ala243Val Single submitter ⚠
- p.Ala280Thr Single submitter ⚠
- p.Ala348Thr Single submitter ⚠
- p.Ala379Thr Single submitter ⚠
- p.Ala390Val Single submitter ⚠
- p.Ala43Thr Single submitter ⚠
- p.Arg121Leu Single submitter ⚠
- p.Arg200Trp Single submitter ⚠
- p.Arg281Trp Single submitter ⚠
- p.Arg331Leu Single submitter ⚠
- p.Arg372His Single submitter ⚠
- p.Arg402His Single submitter ⚠
- p.Arg430His Single submitter ⚠
- p.Arg486His Single submitter ⚠
- p.Arg539Trp Single submitter ⚠
- p.Arg86His Single submitter ⚠
- p.Asn99Ser Single submitter ⚠
- p.Asp522Asn Single submitter ⚠
- p.Asp526Tyr Single submitter ⚠
- p.Cys197Tyr Single submitter ⚠
- p.Cys447Arg Single submitter ⚠
- p.Gln139Arg Single submitter ⚠
- p.Gln259His Single submitter ⚠
- p.Gln34Arg Single submitter ⚠
- p.Gln427His Single submitter ⚠
- p.Glu107Lys Single submitter ⚠
- p.Gly11Arg Single submitter
- p.Gly152Arg Single submitter ⚠
- p.Gly198Ser Single submitter ⚠
- p.Gly209Ser Single submitter ⚠
- p.Gly246Asp Single submitter ⚠
- p.Gly371Arg Single submitter
- p.Gly413Ser Single submitter
- p.Gly46Ser Single submitter ⚠
- p.Gly77Ser Single submitter ⚠
- p.Ile313Thr Single submitter ⚠
- p.Ile443Leu Single submitter ⚠
- p.Ile44Phe Single submitter ⚠
- p.Leu15Pro Single submitter ⚠
- p.Leu173Met Single submitter ⚠
- p.Leu29Phe Single submitter ⚠
- p.Leu377Phe Single submitter ⚠
- p.Leu426Trp Single submitter ⚠
- p.Met478Arg Single submitter ⚠
- p.Met64Val Single submitter ⚠
- p.Phe189Ser Single submitter ⚠
- p.Phe337Leu Single submitter ⚠
- p.Pro171Leu Single submitter ⚠
- p.Pro340Ser Single submitter ⚠
- p.Pro519Leu Single submitter ⚠
- p.Pro82Thr Single submitter ⚠
- p.Ser147Pro Single submitter ⚠
- p.Ser239Arg Single submitter ⚠
- p.Ser332Trp Single submitter ⚠
- p.Ser359Phe Single submitter ⚠
- p.Ser529Arg Single submitter ⚠
- p.Ser532Leu Single submitter ⚠
- p.Ser547Ile Single submitter ⚠
- p.Ser549Leu Single submitter ⚠
- p.Thr101Met Single submitter ⚠
- p.Thr110Met Single submitter ⚠
- p.Thr230Ser Single submitter ⚠
- p.Thr23Ile Single submitter ⚠
- p.Thr428Asn Single submitter ⚠
- p.Thr463Arg Single submitter ⚠
- p.Trp117Cys Single submitter ⚠
- p.Trp160Arg Single submitter ⚠
- p.Val123Ile Single submitter ⚠
- p.Val324Leu Single submitter ⚠
- p.Val499Ile Single submitter ⚠