SLC22A16 — 107 ClinVar variants
All ClinVar germline SLC22A16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
2 Benign · 7 Likely benign · 98 Uncertain significance
Full SLC22A16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 68
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC22A16 p.Ala242Thr Uncertain significance Single submitter
- SLC22A16 p.Ala408Pro Uncertain significance Single submitter
- SLC22A16 p.Ala447Gly Uncertain significance Single submitter
- SLC22A16 p.Ala477Thr Uncertain significance Single submitter
- SLC22A16 p.Arg181Ser Uncertain significance Single submitter
- SLC22A16 p.Arg300Gln Uncertain significance Single submitter
- SLC22A16 p.Arg486Cys Uncertain significance Single submitter
- SLC22A16 p.Asn386Lys Uncertain significance Single submitter
- SLC22A16 p.Asn390Ser Uncertain significance Single submitter
- SLC22A16 p.Asp149His Uncertain significance Single submitter
- SLC22A16 p.Cys285Tyr Uncertain significance Single submitter
- SLC22A16 p.Cys485Phe Uncertain significance Single submitter
- SLC22A16 p.Gln133Glu Uncertain significance Single submitter
- SLC22A16 p.Glu340Asp Uncertain significance Single submitter
- SLC22A16 p.Gly164Arg Uncertain significance Single submitter
- SLC22A16 p.Gly395Asp Uncertain significance Single submitter
- SLC22A16 p.Gly413Arg Uncertain significance Single submitter
- SLC22A16 p.Gly455Arg Uncertain significance Single submitter
- SLC22A16 p.Gly45Arg Uncertain significance Single submitter
- SLC22A16 p.Ile273Phe Uncertain significance Single submitter
- SLC22A16 p.Ile503Val Uncertain significance Single submitter
- SLC22A16 p.Ile568Phe Uncertain significance Single submitter
- SLC22A16 p.Leu23Pro Uncertain significance Single submitter
- SLC22A16 p.Leu288Pro Uncertain significance Single submitter
- SLC22A16 p.Leu322Pro Uncertain significance Single submitter
- SLC22A16 p.Leu325Ile Uncertain significance Single submitter
- SLC22A16 p.Leu325Val Uncertain significance Single submitter
- SLC22A16 p.Leu364Gln Uncertain significance Single submitter
- SLC22A16 p.Leu378Trp Uncertain significance Single submitter
- SLC22A16 p.Leu394Val Uncertain significance Single submitter
- SLC22A16 p.Leu460Phe Uncertain significance Single submitter
- SLC22A16 p.Leu463Val Uncertain significance Single submitter
- SLC22A16 p.Leu516Met Uncertain significance Single submitter
- SLC22A16 p.Lys105Glu Uncertain significance Single submitter
- SLC22A16 p.Lys151Thr Uncertain significance Single submitter
- SLC22A16 p.Met192Leu Uncertain significance Single submitter
- SLC22A16 p.Met448Thr Uncertain significance Single submitter
- SLC22A16 p.Met513Thr Uncertain significance Single submitter
- SLC22A16 p.Met513Val Uncertain significance Single submitter
- SLC22A16 p.Phe373Ser Uncertain significance Single submitter
- SLC22A16 p.Pro292Leu Uncertain significance Single submitter
- SLC22A16 p.Pro338Leu Uncertain significance Single submitter
- SLC22A16 p.Pro338Ser Uncertain significance Single submitter
- SLC22A16 p.Pro493Leu Uncertain significance Single submitter
- SLC22A16 p.Pro525Gln Uncertain significance Single submitter
- SLC22A16 p.Ser110Leu Uncertain significance Single submitter
- SLC22A16 p.Ser169Leu Uncertain significance Single submitter
- SLC22A16 p.Ser323Thr Uncertain significance Single submitter
- SLC22A16 p.Ser354Cys Uncertain significance Single submitter
- SLC22A16 p.Ser380Pro Uncertain significance Single submitter
- SLC22A16 p.Ser480Asn Uncertain significance Single submitter
- SLC22A16 p.Ser517Arg Uncertain significance Single submitter
- SLC22A16 p.Ser548Asn Uncertain significance Single submitter
- SLC22A16 p.Thr117Ala Uncertain significance Single submitter
- SLC22A16 p.Thr117Ile Uncertain significance Single submitter
- SLC22A16 p.Thr207Ile Uncertain significance Single submitter
- SLC22A16 p.Thr276Ala Uncertain significance Single submitter
- SLC22A16 p.Thr356Arg Uncertain significance Single submitter
- SLC22A16 p.Thr361Ser Uncertain significance Single submitter
- SLC22A16 p.Thr557Ala Uncertain significance Single submitter
- SLC22A16 p.Trp136Arg Uncertain significance Single submitter
- SLC22A16 p.Trp152Cys Uncertain significance Single submitter
- SLC22A16 p.Trp286Cys Uncertain significance Single submitter
- SLC22A16 p.Val141Met Uncertain significance Single submitter
- SLC22A16 p.Val165Ala Uncertain significance Single submitter
- SLC22A16 p.Val203Gly Uncertain significance Single submitter
- SLC22A16 p.Val449Gly Uncertain significance Single submitter
- SLC22A16 p.Val496Ala Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- SLC22A16 p.Ala199Glu Uncertain significance Single submitter
- SLC22A16 p.Ala211Gly Uncertain significance Single submitter
- SLC22A16 p.Asn352Tyr Uncertain significance Single submitter
- SLC22A16 p.Glu526Gln Uncertain significance Single submitter
- SLC22A16 p.Gly481Ser Uncertain significance Single submitter
- SLC22A16 p.Ile435Met Uncertain significance Single submitter
- SLC22A16 p.Ile9Met Uncertain significance Single submitter
- SLC22A16 p.Leu296Phe Uncertain significance Single submitter
- SLC22A16 p.Met192Ile Uncertain significance Single submitter
- SLC22A16 p.Met192Lys Uncertain significance Single submitter
- SLC22A16 p.Met231Ile Uncertain significance Single submitter
- SLC22A16 p.Met311Thr Uncertain significance Single submitter
- SLC22A16 p.Met448Ile Uncertain significance Single submitter
- SLC22A16 p.Phe123Leu Uncertain significance Single submitter
- SLC22A16 p.Phe16Ser Uncertain significance Single submitter
- SLC22A16 p.Phe494Leu Uncertain significance Single submitter
- SLC22A16 p.Ser189Gly Uncertain significance Single submitter
- SLC22A16 p.Thr465Ala Uncertain significance Single submitter
- SLC22A16 p.Tyr116His Uncertain significance Single submitter
- SLC22A16 p.Tyr206Cys Uncertain significance Single submitter
- SLC22A16 p.Val147Ile Uncertain significance Single submitter
All SLC22A16 variants
Benign 2
- p.Leu296= Single submitter
- p.Val432Ile Single submitter
Likely benign 7
- p.Ala199Val Single submitter
- p.Ala567Val Single submitter
- p.Gly113Asp Single submitter
- p.Lys105Arg Single submitter
- p.Met231Thr Single submitter
- p.Phe175Leu Single submitter
- p.Thr87Met Single submitter
Uncertain significance 98
- p.Ala199Glu Single submitter ⚠
- p.Ala211Gly Single submitter ⚠
- p.Ala242Thr Single submitter ⚠
- p.Ala401Thr Single submitter
- p.Ala408Pro Single submitter ⚠
- p.Ala447Gly Single submitter ⚠
- p.Ala477Thr Single submitter ⚠
- p.Arg181Ser Single submitter ⚠
- p.Arg300Gln Single submitter ⚠
- p.Arg486Cys Single submitter ⚠
- p.Asn352Tyr Single submitter ⚠
- p.Asn386Lys Single submitter ⚠
- p.Asn390Ser Single submitter ⚠
- p.Asp132Glu Single submitter
- p.Asp149His Single submitter ⚠
- p.Cys285Tyr Single submitter ⚠
- p.Cys485Phe Single submitter ⚠
- p.Gln133Glu Single submitter ⚠
- p.Glu340Asp Single submitter ⚠
- p.Glu526Gln Single submitter ⚠
- p.Glu538Lys Single submitter
- p.Gly164Arg Single submitter ⚠
- p.Gly299Ala Single submitter
- p.Gly395Asp Single submitter ⚠
- p.Gly413Arg Single submitter ⚠
- p.Gly455Arg Single submitter ⚠
- p.Gly45Arg Single submitter ⚠
- p.Gly481Ser Single submitter ⚠
- p.His247Leu Single submitter
- p.Ile273Phe Single submitter ⚠
- p.Ile435Met Single submitter ⚠
- p.Ile503Val Single submitter ⚠
- p.Ile568Phe Single submitter ⚠
- p.Ile9Met Single submitter ⚠
- p.Leu166Ile Single submitter
- p.Leu23Pro Single submitter ⚠
- p.Leu288Phe Single submitter
- p.Leu288Pro Single submitter ⚠
- p.Leu296Phe Single submitter ⚠
- p.Leu322Pro Single submitter ⚠
- p.Leu325Ile Single submitter ⚠
- p.Leu325Val Single submitter ⚠
- p.Leu364Gln Single submitter ⚠
- p.Leu378Trp Single submitter ⚠
- p.Leu394Val Single submitter ⚠
- p.Leu460Phe Single submitter ⚠
- p.Leu463Val Single submitter ⚠
- p.Leu516Met Single submitter ⚠
- p.Lys105Glu Single submitter ⚠
- p.Lys151Thr Single submitter ⚠
- p.Met192Ile Single submitter ⚠
- p.Met192Leu Single submitter ⚠
- p.Met192Lys Single submitter ⚠
- p.Met231Ile Single submitter ⚠
- p.Met311Thr Single submitter ⚠
- p.Met448Ile Single submitter ⚠
- p.Met448Thr Single submitter ⚠
- p.Met513Thr Single submitter ⚠
- p.Met513Val Single submitter ⚠
- p.Phe123Leu Single submitter ⚠
- p.Phe16Ser Single submitter ⚠
- p.Phe373Ser Single submitter ⚠
- p.Phe494Leu Single submitter ⚠
- p.Pro292Leu Single submitter ⚠
- p.Pro338Leu Single submitter ⚠
- p.Pro338Ser Single submitter ⚠
- p.Pro493Leu Single submitter ⚠
- p.Pro525Gln Single submitter ⚠
- p.Ser110Leu Single submitter ⚠
- p.Ser169Leu Single submitter ⚠
- p.Ser189Gly Single submitter ⚠
- p.Ser323Thr Single submitter ⚠
- p.Ser354Cys Single submitter ⚠
- p.Ser380Pro Single submitter ⚠
- p.Ser480Asn Single submitter ⚠
- p.Ser517Arg Single submitter ⚠
- p.Ser548Asn Single submitter ⚠
- p.Thr117Ala Single submitter ⚠
- p.Thr117Ile Single submitter ⚠
- p.Thr207Ile Single submitter ⚠
- p.Thr276Ala Single submitter ⚠
- p.Thr356Arg Single submitter ⚠
- p.Thr361Ser Single submitter ⚠
- p.Thr465Ala Single submitter ⚠
- p.Thr557Ala Single submitter ⚠
- p.Trp136Arg Single submitter ⚠
- p.Trp152Cys Single submitter ⚠
- p.Trp286Cys Single submitter ⚠
- p.Tyr116His Single submitter ⚠
- p.Tyr206Cys Single submitter ⚠
- p.Tyr262Ser Single submitter
- p.Val13Ala Single submitter
- p.Val141Met Single submitter ⚠
- p.Val147Ile Single submitter ⚠
- p.Val165Ala Single submitter ⚠
- p.Val203Gly Single submitter ⚠
- p.Val449Gly Single submitter ⚠
- p.Val496Ala Single submitter ⚠