SLC22A2 — 58 ClinVar variants
All ClinVar germline SLC22A2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
1 Benign · 4 Likely benign · 53 Uncertain significance
Full SLC22A2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC22A2 p.Ala108Thr Uncertain significance Single submitter
- SLC22A2 p.Ala258Thr Uncertain significance Single submitter
- SLC22A2 p.Ala316Thr Uncertain significance Single submitter
- SLC22A2 p.Ala31Thr Uncertain significance Single submitter
- SLC22A2 p.Ala417Thr Uncertain significance Single submitter
- SLC22A2 p.Arg231Gln Uncertain significance Single submitter
- SLC22A2 p.Arg231Trp Uncertain significance Single submitter
- SLC22A2 p.Arg320Cys Uncertain significance Single submitter
- SLC22A2 p.Arg320His Uncertain significance Single submitter
- SLC22A2 p.Arg91Ser Uncertain significance Single submitter
- SLC22A2 p.Asn113Asp Uncertain significance Single submitter
- SLC22A2 p.Asn145Ser Uncertain significance Single submitter
- SLC22A2 p.Asn273Ile Uncertain significance Single submitter
- SLC22A2 p.Asn464Asp Uncertain significance Single submitter
- SLC22A2 p.Asn72Thr Uncertain significance Single submitter
- SLC22A2 p.Glu227Ala Uncertain significance Single submitter
- SLC22A2 p.Glu524Asp Uncertain significance Single submitter
- SLC22A2 p.Gly230Arg Uncertain significance Single submitter
- SLC22A2 p.Gly373Asp Uncertain significance Single submitter
- SLC22A2 p.Gly426Ser Uncertain significance Single submitter
- SLC22A2 p.Gly64Cys Uncertain significance Single submitter
- SLC22A2 p.Gly82Asp Uncertain significance Single submitter
- SLC22A2 p.Ile205Ser Uncertain significance Single submitter
- SLC22A2 p.Ile303Ser Uncertain significance Single submitter
- SLC22A2 p.Ile543Thr Uncertain significance Single submitter
- SLC22A2 p.Leu331Val Uncertain significance Single submitter
- SLC22A2 p.Leu457Val Uncertain significance Single submitter
- SLC22A2 p.Leu493Val Uncertain significance Single submitter
- SLC22A2 p.Lys541Glu Uncertain significance Single submitter
- SLC22A2 p.Met194Val Uncertain significance Single submitter
- SLC22A2 p.Met369Val Uncertain significance Single submitter
- SLC22A2 p.Met412Val Uncertain significance Single submitter
- SLC22A2 p.Met498Thr Uncertain significance Single submitter
- SLC22A2 p.Pro121Arg Uncertain significance Single submitter
- SLC22A2 p.Pro272Leu Uncertain significance Single submitter
- SLC22A2 p.Pro535Arg Uncertain significance Single submitter
- SLC22A2 p.Ser313Phe Uncertain significance Single submitter
- SLC22A2 p.Ser472Leu Uncertain significance Single submitter
- SLC22A2 p.Thr268Ala Uncertain significance Single submitter
- SLC22A2 p.Tyr382Asp Uncertain significance Single submitter
- SLC22A2 p.Tyr73His Uncertain significance Single submitter
- SLC22A2 p.Val158Ile Uncertain significance Single submitter
- SLC22A2 p.Val247Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All SLC22A2 variants
Benign 1
- p.Thr525= Single submitter
Likely benign 4
- p.Arg123Gln Single submitter
- p.Ile398= Single submitter
- p.Ile401= Single submitter
- p.Pro496= Single submitter
Uncertain significance 53
- p.Ala108Thr Single submitter ⚠
- p.Ala258Thr Single submitter ⚠
- p.Ala316Thr Single submitter ⚠
- p.Ala31Thr Single submitter ⚠
- p.Ala417Thr Single submitter ⚠
- p.Arg231Gln Single submitter ⚠
- p.Arg231Trp Single submitter ⚠
- p.Arg320Cys Single submitter ⚠
- p.Arg320His Single submitter ⚠
- p.Arg62His Single submitter ⚠
- p.Arg91Cys Single submitter
- p.Arg91Ser Single submitter ⚠
- p.Asn113Asp Single submitter ⚠
- p.Asn145Ser Single submitter ⚠
- p.Asn273Ile Single submitter ⚠
- p.Asn464Asp Single submitter ⚠
- p.Asn72Thr Single submitter ⚠
- p.Asp399Asn Single submitter
- p.Glu227Ala Single submitter ⚠
- p.Glu524Asp Single submitter ⚠
- p.Gly125Ser Single submitter
- p.Gly230Arg Single submitter ⚠
- p.Gly373Asp Single submitter ⚠
- p.Gly426Ser Single submitter ⚠
- p.Gly64Cys Single submitter ⚠
- p.Gly82Asp Single submitter ⚠
- p.Ile205Ser Single submitter ⚠
- p.Ile303Ser Single submitter ⚠
- p.Ile366Met Single submitter ⚠
- p.Ile543Thr Single submitter ⚠
- p.Leu331Val Single submitter ⚠
- p.Leu457Val Single submitter ⚠
- p.Leu493Val Single submitter ⚠
- p.Lys541Glu Single submitter ⚠
- p.Met194Val Single submitter ⚠
- p.Met369Val Single submitter ⚠
- p.Met412Val Single submitter ⚠
- p.Met498Thr Single submitter ⚠
- p.Pro106Leu Single submitter
- p.Pro106Thr Single submitter ⚠
- p.Pro121Arg Single submitter ⚠
- p.Pro272Leu Single submitter ⚠
- p.Pro535Arg Single submitter ⚠
- p.Ser270Phe Single submitter ⚠
- p.Ser313Phe Single submitter ⚠
- p.Ser472Leu Single submitter ⚠
- p.Thr268Ala Single submitter ⚠
- p.Tyr382Asp Single submitter ⚠
- p.Tyr73His Single submitter ⚠
- p.Val158Ile Single submitter ⚠
- p.Val247Ala Single submitter ⚠
- p.Val360Ala Single submitter
- p.Val511Met Single submitter ⚠