SLC22A3 — 74 ClinVar variants
All ClinVar germline SLC22A3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
3 Benign · 2 Likely benign · 69 Uncertain significance
Full SLC22A3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC22A3 p.Ala102Asp Uncertain significance Single submitter
- SLC22A3 p.Ala57Thr Uncertain significance Single submitter
- SLC22A3 p.Arg128His Uncertain significance Single submitter
- SLC22A3 p.Arg212Cys Uncertain significance Single submitter
- SLC22A3 p.Arg310His Uncertain significance Single submitter
- SLC22A3 p.Arg348Trp Uncertain significance Single submitter
- SLC22A3 p.Arg371His Uncertain significance Single submitter
- SLC22A3 p.Arg407Leu Uncertain significance Single submitter
- SLC22A3 p.Arg545Thr Uncertain significance Single submitter
- SLC22A3 p.Arg73His Uncertain significance Single submitter
- SLC22A3 p.Arg79Leu Uncertain significance Single submitter
- SLC22A3 p.Arg86Gly Uncertain significance Single submitter
- SLC22A3 p.Asn266Ser Uncertain significance Single submitter
- SLC22A3 p.Asn322Lys Uncertain significance Single submitter
- SLC22A3 p.Asn335Asp Uncertain significance Single submitter
- SLC22A3 p.Asn378Asp Uncertain significance Single submitter
- SLC22A3 p.Cys314Tyr Uncertain significance Single submitter
- SLC22A3 p.Glu533Asp Uncertain significance Single submitter
- SLC22A3 p.Glu61Gln Uncertain significance Single submitter
- SLC22A3 p.Glu68Asp Uncertain significance Single submitter
- SLC22A3 p.Glu6Gln Uncertain significance Single submitter
- SLC22A3 p.Glu85Lys Uncertain significance Single submitter
- SLC22A3 p.Gly259Arg Uncertain significance Single submitter
- SLC22A3 p.Gly393Glu Uncertain significance Single submitter
- SLC22A3 p.Gly442Arg Uncertain significance Single submitter
- SLC22A3 p.Gly88Ser Uncertain significance Single submitter
- SLC22A3 p.Ile375Arg Uncertain significance Single submitter
- SLC22A3 p.Ile401Thr Uncertain significance Single submitter
- SLC22A3 p.Ile452Thr Uncertain significance Single submitter
- SLC22A3 p.Ile505Thr Uncertain significance Single submitter
- SLC22A3 p.Leu108Val Uncertain significance Single submitter
- SLC22A3 p.Lys534Glu Uncertain significance Single submitter
- SLC22A3 p.Met153Leu Uncertain significance Single submitter
- SLC22A3 p.Phe263Leu Uncertain significance Single submitter
- SLC22A3 p.Pro2His Uncertain significance Single submitter
- SLC22A3 p.Pro499Leu Uncertain significance Single submitter
- SLC22A3 p.Pro499Ser Uncertain significance Single submitter
- SLC22A3 p.Pro83Ser Uncertain significance Single submitter
- SLC22A3 p.Ser236Leu Uncertain significance Single submitter
- SLC22A3 p.Ser78Pro Uncertain significance Single submitter
- SLC22A3 p.Thr105Ser Uncertain significance Single submitter
- SLC22A3 p.Thr440Ala Uncertain significance Single submitter
- SLC22A3 p.Trp267Cys Uncertain significance Single submitter
- SLC22A3 p.Val147Leu Uncertain significance Single submitter
- SLC22A3 p.Val183Ile Uncertain significance Single submitter
- SLC22A3 p.Val217Glu Uncertain significance Single submitter
- SLC22A3 p.Val228Leu Uncertain significance Single submitter
- SLC22A3 p.Val242Ala Uncertain significance Single submitter
- SLC22A3 p.Val245Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- SLC22A3 p.Arg298Trp Uncertain significance Single submitter
- SLC22A3 p.Arg371Ser Uncertain significance Single submitter
- SLC22A3 p.Arg73Ser Uncertain significance Single submitter
- SLC22A3 p.Arg92Cys Uncertain significance Single submitter
- SLC22A3 p.Asp5Ala Uncertain significance Single submitter
- SLC22A3 p.Glu96Gln Uncertain significance Single submitter
- SLC22A3 p.Gly376Val Uncertain significance Single submitter
- SLC22A3 p.Gly377Ser Uncertain significance Single submitter
- SLC22A3 p.Ile244Thr Uncertain significance Single submitter
- SLC22A3 p.Leu124Pro Uncertain significance Single submitter
- SLC22A3 p.Phe170Leu Uncertain significance Single submitter
- SLC22A3 p.Phe218Ile Uncertain significance Single submitter
- SLC22A3 p.Phe468Ser Uncertain significance Single submitter
- SLC22A3 p.Ser78Cys Uncertain significance Single submitter
- SLC22A3 p.Val494Met Uncertain significance Single submitter
All SLC22A3 variants
Benign 3
- c.430-10863C>T Single submitter
- c.-29G>A Single submitter
- p.Ala411= Single submitter
Likely benign 2
- p.Arg86= Single submitter
- p.Val11Ala Single submitter
Uncertain significance 69
- p.Ala102Asp Single submitter ⚠
- p.Ala57Thr Single submitter ⚠
- p.Arg128His Single submitter ⚠
- p.Arg212Cys Single submitter ⚠
- p.Arg298Trp Single submitter ⚠
- p.Arg310His Single submitter ⚠
- p.Arg348Trp Single submitter ⚠
- p.Arg371His Single submitter ⚠
- p.Arg371Ser Single submitter ⚠
- p.Arg407Leu Single submitter ⚠
- p.Arg545Thr Single submitter ⚠
- p.Arg73His Single submitter ⚠
- p.Arg73Ser Single submitter ⚠
- p.Arg79Leu Single submitter ⚠
- p.Arg86Gly Single submitter ⚠
- p.Arg92Cys Single submitter ⚠
- p.Asn204Lys Single submitter
- p.Asn266Ser Single submitter ⚠
- p.Asn322Lys Single submitter ⚠
- p.Asn335Asp Single submitter ⚠
- p.Asn378Asp Single submitter ⚠
- p.Asp5Ala Single submitter ⚠
- p.Cys314Tyr Single submitter ⚠
- p.Glu533Asp Single submitter ⚠
- p.Glu61Gln Single submitter ⚠
- p.Glu68Asp Single submitter ⚠
- p.Glu6Gln Single submitter ⚠
- p.Glu85Lys Single submitter ⚠
- p.Glu96Gln Single submitter ⚠
- p.Gly259Arg Single submitter ⚠
- p.Gly376Val Single submitter ⚠
- p.Gly377Ser Single submitter ⚠
- p.Gly393Glu Single submitter ⚠
- p.Gly442Arg Single submitter ⚠
- p.Gly88Ser Single submitter ⚠
- p.Ile244Thr Single submitter ⚠
- p.Ile375Arg Single submitter ⚠
- p.Ile401Thr Single submitter ⚠
- p.Ile452Thr Single submitter ⚠
- p.Ile505Thr Single submitter ⚠
- p.Leu108Val Single submitter ⚠
- p.Leu124Pro Single submitter ⚠
- p.Leu399Pro Single submitter
- p.Lys534Glu Single submitter ⚠
- p.Met153Leu Single submitter ⚠
- p.Phe170Leu Single submitter ⚠
- p.Phe218Ile Single submitter ⚠
- p.Phe263Leu Single submitter ⚠
- p.Phe468Ser Single submitter ⚠
- p.Pro2His Single submitter ⚠
- p.Pro409Ser Single submitter
- p.Pro499Leu Single submitter ⚠
- p.Pro499Ser Single submitter ⚠
- p.Pro83Ser Single submitter ⚠
- p.Ser236Leu Single submitter ⚠
- p.Ser78Cys Single submitter ⚠
- p.Ser78Pro Single submitter ⚠
- p.Thr105Ser Single submitter ⚠
- p.Thr275Met Single submitter
- p.Thr440Ala Single submitter ⚠
- p.Trp267Cys Single submitter ⚠
- p.Val147Leu Single submitter ⚠
- p.Val183Ile Single submitter ⚠
- p.Val217Glu Single submitter ⚠
- p.Val228Leu Single submitter ⚠
- p.Val242Ala Single submitter ⚠
- p.Val245Met Single submitter ⚠
- p.Val39Ala Single submitter
- p.Val494Met Single submitter ⚠