SLC22A8 — 67 ClinVar variants
All ClinVar germline SLC22A8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
3 Benign · 7 Likely benign · 57 Uncertain significance
Full SLC22A8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC22A8 p.Ala231Thr Uncertain significance Single submitter
- SLC22A8 p.Ala482Thr Uncertain significance Single submitter
- SLC22A8 p.Ala514Val Uncertain significance Single submitter
- SLC22A8 p.Ala526Ser Uncertain significance Single submitter
- SLC22A8 p.Arg291Ser Uncertain significance Single submitter
- SLC22A8 p.Arg75Cys Uncertain significance Single submitter
- SLC22A8 p.Arg9His Uncertain significance Single submitter
- SLC22A8 p.Asn54Ser Uncertain significance Single submitter
- SLC22A8 p.Asn86Asp Uncertain significance Single submitter
- SLC22A8 p.Cys421Arg Uncertain significance Single submitter
- SLC22A8 p.Gly132Asp Uncertain significance Single submitter
- SLC22A8 p.Gly164Cys Uncertain significance Single submitter
- SLC22A8 p.Gly184Cys Uncertain significance Single submitter
- SLC22A8 p.Gly221Val Uncertain significance Single submitter
- SLC22A8 p.Gly338Ser Uncertain significance Single submitter
- SLC22A8 p.Gly447Val Uncertain significance Single submitter
- SLC22A8 p.Gly467Asp Uncertain significance Single submitter
- SLC22A8 p.Gly58Glu Uncertain significance Single submitter
- SLC22A8 p.His20Gln Uncertain significance Single submitter
- SLC22A8 p.Ile275Val Uncertain significance Single submitter
- SLC22A8 p.Leu143Pro Uncertain significance Single submitter
- SLC22A8 p.Leu307Ser Uncertain significance Single submitter
- SLC22A8 p.Leu380Pro Uncertain significance Single submitter
- SLC22A8 p.Leu391Phe Uncertain significance Single submitter
- SLC22A8 p.Leu500Ser Uncertain significance Single submitter
- SLC22A8 p.Leu74Phe Uncertain significance Single submitter
- SLC22A8 p.Met13Thr Uncertain significance Single submitter
- SLC22A8 p.Met326Thr Uncertain significance Single submitter
- SLC22A8 p.Phe185Leu Uncertain significance Single submitter
- SLC22A8 p.Pro438Thr Uncertain significance Single submitter
- SLC22A8 p.Pro534Ser Uncertain significance Single submitter
- SLC22A8 p.Pro537Thr Uncertain significance Single submitter
- SLC22A8 p.Pro66Ser Uncertain significance Single submitter
- SLC22A8 p.Ser331Phe Uncertain significance Single submitter
- SLC22A8 p.Ser425Thr Uncertain significance Single submitter
- SLC22A8 p.Ser449Asn Uncertain significance Single submitter
- SLC22A8 p.Thr212Ile Uncertain significance Single submitter
- SLC22A8 p.Thr409Ile Uncertain significance Single submitter
- SLC22A8 p.Thr57Ile Uncertain significance Single submitter
- SLC22A8 p.Trp235Ser Uncertain significance Single submitter
- SLC22A8 p.Val109Met Uncertain significance Single submitter
- SLC22A8 p.Val139Met Uncertain significance Single submitter
- SLC22A8 p.Val178Gly Uncertain significance Single submitter
- SLC22A8 p.Val195Ile Uncertain significance Single submitter
- SLC22A8 p.Val413Ile Uncertain significance Single submitter
- SLC22A8 p.Val469Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- SLC22A8 p.Arg319Gln Uncertain significance Single submitter
- SLC22A8 p.Arg325Cys Uncertain significance Single submitter
- SLC22A8 p.Arg325His Uncertain significance Single submitter
- SLC22A8 p.Arg9Cys Uncertain significance Single submitter
- SLC22A8 p.Gly189Ala Uncertain significance Single submitter
- SLC22A8 p.Gly227Ser Uncertain significance Single submitter
- SLC22A8 p.Leu121Pro Uncertain significance Single submitter
- SLC22A8 p.Leu159Gln Uncertain significance Single submitter
- SLC22A8 p.Lys122Gln Uncertain significance Single submitter
- SLC22A8 p.Pro368Leu Uncertain significance Single submitter
All SLC22A8 variants
Benign 3
- p.Ile305Phe Multiple submitters
- p.Ile530= Multiple submitters
- p.Val281Ala Multiple submitters
Likely benign 7
- p.Ala43Thr Single submitter
- p.Arg205Gln Single submitter
- p.Arg513Gln Single submitter
- p.His15Arg Single submitter
- p.Leu344= Single submitter
- p.Met326Val Single submitter
- p.Val248Ile Single submitter
Uncertain significance 57
- p.Ala231Thr Single submitter ⚠
- p.Ala482Thr Single submitter ⚠
- p.Ala514Val Single submitter ⚠
- p.Ala526Ser Single submitter ⚠
- p.Arg291Ser Single submitter ⚠
- p.Arg319Gln Single submitter ⚠
- p.Arg325Cys Single submitter ⚠
- p.Arg325His Single submitter ⚠
- p.Arg75Cys Single submitter ⚠
- p.Arg9Cys Single submitter ⚠
- p.Arg9His Single submitter ⚠
- p.Asn54Ser Single submitter ⚠
- p.Asn86Asp Single submitter ⚠
- p.Cys421Arg Single submitter ⚠
- p.Gln443Pro Single submitter
- p.Gly132Asp Single submitter ⚠
- p.Gly164Cys Single submitter ⚠
- p.Gly184Cys Single submitter ⚠
- p.Gly189Ala Single submitter ⚠
- p.Gly221Val Single submitter ⚠
- p.Gly227Ser Single submitter ⚠
- p.Gly338Ser Single submitter ⚠
- p.Gly447Val Single submitter ⚠
- p.Gly467Asp Single submitter ⚠
- p.Gly58Glu Single submitter ⚠
- p.His20Gln Single submitter ⚠
- p.Ile275Val Single submitter ⚠
- p.Leu121Pro Single submitter ⚠
- p.Leu143Pro Single submitter ⚠
- p.Leu159Gln Single submitter ⚠
- p.Leu307Ser Single submitter ⚠
- p.Leu380Pro Single submitter ⚠
- p.Leu391Phe Single submitter ⚠
- p.Leu500Ser Single submitter ⚠
- p.Leu74Phe Single submitter ⚠
- p.Lys122Gln Single submitter ⚠
- p.Met13Thr Single submitter ⚠
- p.Met326Thr Single submitter ⚠
- p.Phe185Leu Single submitter ⚠
- p.Pro368Leu Single submitter ⚠
- p.Pro438Thr Single submitter ⚠
- p.Pro534Ser Single submitter ⚠
- p.Pro537Thr Single submitter ⚠
- p.Pro66Ser Single submitter ⚠
- p.Ser331Phe Single submitter ⚠
- p.Ser425Thr Single submitter ⚠
- p.Ser449Asn Single submitter ⚠
- p.Thr212Ile Single submitter ⚠
- p.Thr409Ile Single submitter ⚠
- p.Thr57Ile Single submitter ⚠
- p.Trp235Ser Single submitter ⚠
- p.Val109Met Single submitter ⚠
- p.Val139Met Single submitter ⚠
- p.Val178Gly Single submitter ⚠
- p.Val195Ile Single submitter ⚠
- p.Val413Ile Single submitter ⚠
- p.Val469Ile Single submitter ⚠