Sugi Variant

Sugi Variant/SLC26A5

SLC26A5 — 319 ClinVar variants

All ClinVar germline SLC26A5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 131 flagged for review →

14 Pathogenic · 8 Likely pathogenic · 16 Conflicting · 40 Benign · 12 Benign/Likely benign · 83 Likely benign · 146 Uncertain significance

Full SLC26A5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 131

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 8

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 100

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 23

The independent predictors disagree with each other — read with care.

All SLC26A5 variants

Pathogenic 14

Likely pathogenic 8

Conflicting classifications of pathogenicity 16

Benign 40

Benign/Likely benign 12

Likely benign 83

Uncertain significance 146