SLC28A2 — 93 ClinVar variants
All ClinVar germline SLC28A2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
2 Benign · 3 Likely benign · 88 Uncertain significance
Full SLC28A2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 69
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC28A2 p.Ala164Thr Uncertain significance Single submitter
- SLC28A2 p.Ala196Thr Uncertain significance Single submitter
- SLC28A2 p.Ala380Ser Uncertain significance Single submitter
- SLC28A2 p.Ala440Gly Uncertain significance Single submitter
- SLC28A2 p.Ala591Val Uncertain significance Single submitter
- SLC28A2 p.Ala644Asp Uncertain significance Single submitter
- SLC28A2 p.Ala91Val Uncertain significance Single submitter
- SLC28A2 p.Arg103Lys Uncertain significance Single submitter
- SLC28A2 p.Arg399Cys Uncertain significance Single submitter
- SLC28A2 p.Arg7Gly Uncertain significance Single submitter
- SLC28A2 p.Asn627Asp Uncertain significance Single submitter
- SLC28A2 p.Asn627His Uncertain significance Single submitter
- SLC28A2 p.Gln173Lys Uncertain significance Single submitter
- SLC28A2 p.Gln42His Uncertain significance Single submitter
- SLC28A2 p.Gln456Glu Uncertain significance Single submitter
- SLC28A2 p.Gln56Arg Uncertain significance Single submitter
- SLC28A2 p.Gln56Lys Uncertain significance Single submitter
- SLC28A2 p.Gln8His Uncertain significance Single submitter
- SLC28A2 p.Glu517Val Uncertain significance Single submitter
- SLC28A2 p.Gly205Asp Uncertain significance Single submitter
- SLC28A2 p.Gly243Ser Uncertain significance Single submitter
- SLC28A2 p.Gly394Arg Uncertain significance Single submitter
- SLC28A2 p.Gly412Arg Uncertain significance Single submitter
- SLC28A2 p.Gly43Arg Uncertain significance Single submitter
- SLC28A2 p.Gly650Arg Uncertain significance Single submitter
- SLC28A2 p.His194Gln Uncertain significance Single submitter
- SLC28A2 p.Ile214Met Uncertain significance Single submitter
- SLC28A2 p.Ile577Val Uncertain significance Single submitter
- SLC28A2 p.Leu143Arg Uncertain significance Single submitter
- SLC28A2 p.Leu145Pro Uncertain significance Single submitter
- SLC28A2 p.Leu26Pro Uncertain significance Single submitter
- SLC28A2 p.Leu278Pro Uncertain significance Single submitter
- SLC28A2 p.Leu280Phe Uncertain significance Single submitter
- SLC28A2 p.Leu379Pro Uncertain significance Single submitter
- SLC28A2 p.Leu453Phe Uncertain significance Single submitter
- SLC28A2 p.Leu549Ser Uncertain significance Single submitter
- SLC28A2 p.Leu82Phe Uncertain significance Single submitter
- SLC28A2 p.Lys378Gln Uncertain significance Single submitter
- SLC28A2 p.Met182Thr Uncertain significance Single submitter
- SLC28A2 p.Met368Val Uncertain significance Single submitter
- SLC28A2 p.Met479Val Uncertain significance Single submitter
- SLC28A2 p.Met510Ile Uncertain significance Single submitter
- SLC28A2 p.Met643Leu Uncertain significance Single submitter
- SLC28A2 p.Phe108Ser Uncertain significance Single submitter
- SLC28A2 p.Phe138Ser Uncertain significance Single submitter
- SLC28A2 p.Phe151Leu Uncertain significance Single submitter
- SLC28A2 p.Pro171Ala Uncertain significance Single submitter
- SLC28A2 p.Pro382Leu Uncertain significance Single submitter
- SLC28A2 p.Pro52Arg Uncertain significance Single submitter
- SLC28A2 p.Pro52Leu Uncertain significance Single submitter
- SLC28A2 p.Pro599Ser Uncertain significance Single submitter
- SLC28A2 p.Ser13Cys Uncertain significance Single submitter
- SLC28A2 p.Ser366Phe Uncertain significance Single submitter
- SLC28A2 p.Ser387Thr Uncertain significance Single submitter
- SLC28A2 p.Ser540Gly Uncertain significance Single submitter
- SLC28A2 p.Ser558Thr Uncertain significance Single submitter
- SLC28A2 p.Thr14Ala Uncertain significance Single submitter
- SLC28A2 p.Thr338Ala Uncertain significance Single submitter
- SLC28A2 p.Thr529Ala Uncertain significance Single submitter
- SLC28A2 p.Thr530Ile Uncertain significance Single submitter
- SLC28A2 p.Thr601Pro Uncertain significance Single submitter
- SLC28A2 p.Thr610Ser Uncertain significance Single submitter
- SLC28A2 p.Thr72Ala Uncertain significance Single submitter
- SLC28A2 p.Tyr381Phe Uncertain significance Single submitter
- SLC28A2 p.Val154Ile Uncertain significance Single submitter
- SLC28A2 p.Val253Ile Uncertain significance Single submitter
- SLC28A2 p.Val284Ile Uncertain significance Single submitter
- SLC28A2 p.Val312Leu Uncertain significance Single submitter
- SLC28A2 p.Val656Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- SLC28A2 p.Ala335Val Uncertain significance Single submitter
- SLC28A2 p.Arg322Cys Uncertain significance Single submitter
- SLC28A2 p.Arg506Cys Uncertain significance Single submitter
- SLC28A2 p.Arg556Trp Uncertain significance Single submitter
- SLC28A2 p.Cys270Tyr Uncertain significance Single submitter
- SLC28A2 p.Cys459Tyr Uncertain significance Single submitter
- SLC28A2 p.Cys657Ser Uncertain significance Single submitter
- SLC28A2 p.Ile184Asn Uncertain significance Single submitter
- SLC28A2 p.Ile417Thr Uncertain significance Single submitter
- SLC28A2 p.Leu185His Uncertain significance Single submitter
- SLC28A2 p.Met314Thr Uncertain significance Single submitter
- SLC28A2 p.Pro171Leu Uncertain significance Single submitter
- SLC28A2 p.Ser9Tyr Uncertain significance Single submitter
- SLC28A2 p.Tyr461Cys Uncertain significance Single submitter
- SLC28A2 p.Val563Asp Uncertain significance Single submitter
All SLC28A2 variants
Benign 2
- p.Pro22Leu Multiple submitters
- p.Ser75Arg Multiple submitters
Likely benign 3
- p.Ala41Thr Single submitter
- p.Ile514Thr Single submitter
- p.Val357Ile Single submitter
Uncertain significance 88
- p.Ala164Thr Single submitter ⚠
- p.Ala196Thr Single submitter ⚠
- p.Ala335Val Single submitter ⚠
- p.Ala380Ser Single submitter ⚠
- p.Ala440Gly Single submitter ⚠
- p.Ala591Val Single submitter ⚠
- p.Ala644Asp Single submitter ⚠
- p.Ala91Val Single submitter ⚠
- p.Arg103Lys Single submitter ⚠
- p.Arg322Cys Single submitter ⚠
- p.Arg399Cys Single submitter ⚠
- p.Arg506Cys Single submitter ⚠
- p.Arg556Trp Single submitter ⚠
- p.Arg7Gly Single submitter ⚠
- p.Asn438Thr Single submitter
- p.Asn627Asp Single submitter ⚠
- p.Asn627His Single submitter ⚠
- p.Cys270Tyr Single submitter ⚠
- p.Cys459Tyr Single submitter ⚠
- p.Cys657Ser Single submitter ⚠
- p.Gln173Lys Single submitter ⚠
- p.Gln42His Single submitter ⚠
- p.Gln456Glu Single submitter ⚠
- p.Gln56Arg Single submitter ⚠
- p.Gln56Lys Single submitter ⚠
- p.Gln8His Single submitter ⚠
- p.Glu517Val Single submitter ⚠
- p.Gly205Asp Single submitter ⚠
- p.Gly243Ser Single submitter ⚠
- p.Gly340Ala Single submitter
- p.Gly394Arg Single submitter ⚠
- p.Gly412Arg Single submitter ⚠
- p.Gly43Arg Single submitter ⚠
- p.Gly650Arg Single submitter ⚠
- p.His194Gln Single submitter ⚠
- p.Ile184Asn Single submitter ⚠
- p.Ile214Met Single submitter ⚠
- p.Ile417Thr Single submitter ⚠
- p.Ile577Val Single submitter ⚠
- p.Leu143Arg Single submitter ⚠
- p.Leu145Pro Single submitter ⚠
- p.Leu185His Single submitter ⚠
- p.Leu26Pro Single submitter ⚠
- p.Leu278Pro Single submitter ⚠
- p.Leu280Phe Single submitter ⚠
- p.Leu379Pro Single submitter ⚠
- p.Leu453Phe Single submitter ⚠
- p.Leu549Ser Single submitter ⚠
- p.Leu82Phe Single submitter ⚠
- p.Lys378Gln Single submitter ⚠
- p.Met182Thr Single submitter ⚠
- p.Met314Thr Single submitter ⚠
- p.Met368Val Single submitter ⚠
- p.Met479Val Single submitter ⚠
- p.Met510Ile Single submitter ⚠
- p.Met643Leu Single submitter ⚠
- p.Phe108Ser Single submitter ⚠
- p.Phe138Ser Single submitter ⚠
- p.Phe151Leu Single submitter ⚠
- p.Phe257Ile Single submitter
- p.Phe267Ile Single submitter
- p.Pro171Ala Single submitter ⚠
- p.Pro171Leu Single submitter ⚠
- p.Pro382Leu Single submitter ⚠
- p.Pro52Arg Single submitter ⚠
- p.Pro52Leu Single submitter ⚠
- p.Pro599Ser Single submitter ⚠
- p.Ser13Cys Single submitter ⚠
- p.Ser366Phe Single submitter ⚠
- p.Ser387Thr Single submitter ⚠
- p.Ser540Gly Single submitter ⚠
- p.Ser558Thr Single submitter ⚠
- p.Ser9Tyr Single submitter ⚠
- p.Thr14Ala Single submitter ⚠
- p.Thr338Ala Single submitter ⚠
- p.Thr529Ala Single submitter ⚠
- p.Thr530Ile Single submitter ⚠
- p.Thr601Pro Single submitter ⚠
- p.Thr610Ser Single submitter ⚠
- p.Thr72Ala Single submitter ⚠
- p.Tyr381Phe Single submitter ⚠
- p.Tyr461Cys Single submitter ⚠
- p.Val154Ile Single submitter ⚠
- p.Val253Ile Single submitter ⚠
- p.Val284Ile Single submitter ⚠
- p.Val312Leu Single submitter ⚠
- p.Val563Asp Single submitter ⚠
- p.Val656Ile Single submitter ⚠