SLC28A3 — 81 ClinVar variants
All ClinVar germline SLC28A3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
4 Benign · 5 Likely benign · 72 Uncertain significance
Full SLC28A3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC28A3 p.Ala362Thr Uncertain significance Single submitter
- SLC28A3 p.Ala366Thr Uncertain significance Single submitter
- SLC28A3 p.Ala451Thr Uncertain significance Single submitter
- SLC28A3 p.Ala467Pro Uncertain significance Single submitter
- SLC28A3 p.Ala559Ser Uncertain significance Single submitter
- SLC28A3 p.Ala588Thr Uncertain significance Single submitter
- SLC28A3 p.Arg102Trp Uncertain significance Single submitter
- SLC28A3 p.Arg4Ser Uncertain significance Single submitter
- SLC28A3 p.Asn518Lys Uncertain significance Single submitter
- SLC28A3 p.Asp62Asn Uncertain significance Single submitter
- SLC28A3 p.Asp72Glu Uncertain significance Single submitter
- SLC28A3 p.Asp74His Uncertain significance Single submitter
- SLC28A3 p.Cys486Arg Uncertain significance Single submitter
- SLC28A3 p.Gln61Glu Uncertain significance Single submitter
- SLC28A3 p.Glu75Asp Uncertain significance Single submitter
- SLC28A3 p.Gly107Asp Uncertain significance Single submitter
- SLC28A3 p.Gly205Ser Uncertain significance Single submitter
- SLC28A3 p.Gly367Ala Uncertain significance Single submitter
- SLC28A3 p.Gly439Glu Uncertain significance Single submitter
- SLC28A3 p.Gly537Glu Uncertain significance Single submitter
- SLC28A3 p.His47Tyr Uncertain significance Single submitter
- SLC28A3 p.His69Gln Uncertain significance Single submitter
- SLC28A3 p.Ile105Thr Uncertain significance Single submitter
- SLC28A3 p.Ile208Met Uncertain significance Single submitter
- SLC28A3 p.Ile311Val Uncertain significance Single submitter
- SLC28A3 p.Ile371Phe Uncertain significance Single submitter
- SLC28A3 p.Ile444Leu Uncertain significance Single submitter
- SLC28A3 p.Ile548Val Uncertain significance Single submitter
- SLC28A3 p.Leu26Pro Uncertain significance Single submitter
- SLC28A3 p.Leu352Ser Uncertain significance Single submitter
- SLC28A3 p.Lys405Gln Uncertain significance Single submitter
- SLC28A3 p.Lys80Arg Uncertain significance Single submitter
- SLC28A3 p.Met364Arg Uncertain significance Single submitter
- SLC28A3 p.Met424Ile Uncertain significance Single submitter
- SLC28A3 p.Met506Val Uncertain significance Single submitter
- SLC28A3 p.Met579Val Uncertain significance Single submitter
- SLC28A3 p.Met70Val Uncertain significance Single submitter
- SLC28A3 p.Ser32Pro Uncertain significance Single submitter
- SLC28A3 p.Ser386Pro Uncertain significance Single submitter
- SLC28A3 p.Ser631Ala Uncertain significance Single submitter
- SLC28A3 p.Ser646Asn Uncertain significance Single submitter
- SLC28A3 p.Thr89Ile Uncertain significance Single submitter
- SLC28A3 p.Trp231Arg Uncertain significance Single submitter
- SLC28A3 p.Trp310Arg Uncertain significance Single submitter
- SLC28A3 p.Trp317Arg Uncertain significance Single submitter
- SLC28A3 p.Val17Met Uncertain significance Single submitter
- SLC28A3 p.Val447Glu Uncertain significance Single submitter
- SLC28A3 p.Val600Met Uncertain significance Single submitter
- SLC28A3 p.Val617Ala Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- SLC28A3 p.Ala190Pro Uncertain significance Single submitter
- SLC28A3 p.Arg551His Uncertain significance Single submitter
- SLC28A3 p.Arg585Cys Uncertain significance Single submitter
- SLC28A3 p.Asn518Ser Uncertain significance Single submitter
- SLC28A3 p.Gly18Asp Uncertain significance Single submitter
- SLC28A3 p.Gly543Arg Uncertain significance Single submitter
- SLC28A3 p.Gly574Ser Uncertain significance Single submitter
- SLC28A3 p.Gly92Arg Uncertain significance Single submitter
- SLC28A3 p.His361Gln Uncertain significance Single submitter
- SLC28A3 p.His361Tyr Uncertain significance Single submitter
- SLC28A3 p.Leu360Phe Uncertain significance Single submitter
- SLC28A3 p.Leu401Val Uncertain significance Single submitter
- SLC28A3 p.Leu510Val Uncertain significance Single submitter
- SLC28A3 p.Pro414Leu Uncertain significance Single submitter
- SLC28A3 p.Ser179Arg Uncertain significance Single submitter
- SLC28A3 p.Ser589Leu Uncertain significance Single submitter
- SLC28A3 p.Thr342Met Uncertain significance Single submitter
- SLC28A3 p.Val292Met Uncertain significance Single submitter
- SLC28A3 p.Val521Ala Uncertain significance Single submitter
All SLC28A3 variants
Benign 4
Likely benign 5
- p.Met209Thr Single submitter
- p.Ser325Thr Single submitter
- p.Thr323Met Single submitter
- p.Val182Ile Single submitter
- p.Val59Ile Single submitter
Uncertain significance 72
- p.Ala190Pro Single submitter ⚠
- p.Ala362Thr Single submitter ⚠
- p.Ala366Thr Single submitter ⚠
- p.Ala451Thr Single submitter ⚠
- p.Ala467Pro Single submitter ⚠
- p.Ala559Ser Single submitter ⚠
- p.Ala559Thr Single submitter
- p.Ala588Thr Single submitter ⚠
- p.Arg102Trp Single submitter ⚠
- p.Arg4Ser Single submitter ⚠
- p.Arg551His Single submitter ⚠
- p.Arg585Cys Single submitter ⚠
- p.Asn518Lys Single submitter ⚠
- p.Asn518Ser Single submitter ⚠
- p.Asp62Asn Single submitter ⚠
- p.Asp72Glu Single submitter ⚠
- p.Asp74His Single submitter ⚠
- p.Cys486Arg Single submitter ⚠
- p.Gln61Glu Single submitter ⚠
- p.Glu75Asp Single submitter ⚠
- p.Gly107Asp Single submitter ⚠
- p.Gly18Asp Single submitter ⚠
- p.Gly205Ser Single submitter ⚠
- p.Gly367Ala Single submitter ⚠
- p.Gly439Glu Single submitter ⚠
- p.Gly537Glu Single submitter ⚠
- p.Gly543Arg Single submitter ⚠
- p.Gly574Ser Single submitter ⚠
- p.Gly92Arg Single submitter ⚠
- p.His361Gln Single submitter ⚠
- p.His361Tyr Single submitter ⚠
- p.His47Tyr Single submitter ⚠
- p.His69Gln Single submitter ⚠
- p.Ile105Thr Single submitter ⚠
- p.Ile208Met Single submitter ⚠
- p.Ile311Val Single submitter ⚠
- p.Ile371Phe Single submitter ⚠
- p.Ile444Leu Single submitter ⚠
- p.Ile548Val Single submitter ⚠
- p.Leu26Pro Single submitter ⚠
- p.Leu352Ser Single submitter ⚠
- p.Leu360Phe Single submitter ⚠
- p.Leu401Val Single submitter ⚠
- p.Leu510Val Single submitter ⚠
- p.Lys405Gln Single submitter ⚠
- p.Lys80Arg Single submitter ⚠
- p.Met364Arg Single submitter ⚠
- p.Met424Ile Single submitter ⚠
- p.Met506Val Single submitter ⚠
- p.Met579Val Single submitter ⚠
- p.Met70Val Single submitter ⚠
- p.Pro290Leu Single submitter
- p.Pro327Arg Single submitter
- p.Pro414Leu Single submitter ⚠
- p.Ser179Arg Single submitter ⚠
- p.Ser32Pro Single submitter ⚠
- p.Ser386Pro Single submitter ⚠
- p.Ser589Leu Single submitter ⚠
- p.Ser631Ala Single submitter ⚠
- p.Ser646Asn Single submitter ⚠
- p.Thr342Met Single submitter ⚠
- p.Thr89Ile Single submitter ⚠
- p.Trp231Arg Single submitter ⚠
- p.Trp310Arg Single submitter ⚠
- p.Trp317Arg Single submitter ⚠
- p.Val17Met Single submitter ⚠
- p.Val292Met Single submitter ⚠
- p.Val348Ala Single submitter
- p.Val447Glu Single submitter ⚠
- p.Val521Ala Single submitter ⚠
- p.Val600Met Single submitter ⚠
- p.Val617Ala Single submitter ⚠