SLC2A3 — 70 ClinVar variants
All ClinVar germline SLC2A3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
2 Benign · 9 Likely benign · 59 Uncertain significance
Full SLC2A3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC2A3 p.Ala149Pro Uncertain significance Single submitter
- SLC2A3 p.Ala423Thr Uncertain significance Single submitter
- SLC2A3 p.Ala429Gly Uncertain significance Single submitter
- SLC2A3 p.Ala464Val Uncertain significance Single submitter
- SLC2A3 p.Ala52Val Uncertain significance Single submitter
- SLC2A3 p.Arg267Gln Uncertain significance Single submitter
- SLC2A3 p.Arg398Cys Uncertain significance Single submitter
- SLC2A3 p.Arg398Leu Uncertain significance Single submitter
- SLC2A3 p.Arg463Gln Uncertain significance Single submitter
- SLC2A3 p.Arg87His Uncertain significance Single submitter
- SLC2A3 p.Asn409Ser Uncertain significance Single submitter
- SLC2A3 p.Gln254His Uncertain significance Single submitter
- SLC2A3 p.Gln281His Uncertain significance Single submitter
- SLC2A3 p.Glu482Gln Uncertain significance Single submitter
- SLC2A3 p.Glu487Lys Uncertain significance Single submitter
- SLC2A3 p.Gly361Glu Uncertain significance Single submitter
- SLC2A3 p.Gly479Ser Uncertain significance Single submitter
- SLC2A3 p.Gly77Arg Uncertain significance Single submitter
- SLC2A3 p.Ile214Thr Uncertain significance Single submitter
- SLC2A3 p.Ile271Val Uncertain significance Single submitter
- SLC2A3 p.Ile388Thr Uncertain significance Single submitter
- SLC2A3 p.Ile388Val Uncertain significance Single submitter
- SLC2A3 p.Leu125Val Uncertain significance Single submitter
- SLC2A3 p.Leu276Phe Uncertain significance Single submitter
- SLC2A3 p.Lys112Glu Uncertain significance Single submitter
- SLC2A3 p.Lys44Thr Uncertain significance Single submitter
- SLC2A3 p.Lys490Thr Uncertain significance Single submitter
- SLC2A3 p.Met249Val Uncertain significance Single submitter
- SLC2A3 p.Met483Ile Uncertain significance Single submitter
- SLC2A3 p.Met94Val Uncertain significance Single submitter
- SLC2A3 p.Phe176Leu Uncertain significance Single submitter
- SLC2A3 p.Phe344Leu Uncertain significance Single submitter
- SLC2A3 p.Phe442Val Uncertain significance Single submitter
- SLC2A3 p.Pro147Ser Uncertain significance Single submitter
- SLC2A3 p.Pro185Leu Uncertain significance Single submitter
- SLC2A3 p.Pro206Thr Uncertain significance Single submitter
- SLC2A3 p.Pro209Thr Uncertain significance Single submitter
- SLC2A3 p.Pro421Leu Uncertain significance Single submitter
- SLC2A3 p.Thr232Ala Uncertain significance Single submitter
- SLC2A3 p.Thr333Ile Uncertain significance Single submitter
- SLC2A3 p.Val320Ile Uncertain significance Single submitter
- SLC2A3 p.Val72Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- SLC2A3 p.Ala401Gly Uncertain significance Single submitter
- SLC2A3 p.Arg463Trp Uncertain significance Single submitter
- SLC2A3 p.Glu259Gly Uncertain significance Single submitter
- SLC2A3 p.Gly50Ala Likely benign Single submitter
- SLC2A3 p.Ile214Met Uncertain significance Single submitter
- SLC2A3 p.Met402Val Uncertain significance Single submitter
- SLC2A3 p.Phe137Leu Uncertain significance Single submitter
- SLC2A3 p.Phe376Cys Uncertain significance Single submitter
- SLC2A3 p.Phe387Ile Uncertain significance Single submitter
- SLC2A3 p.Pro54Ser Likely benign Single submitter
- SLC2A3 p.Thr60Met Uncertain significance Single submitter
All SLC2A3 variants
Benign 2
- c.1068+4G>A Multiple submitters
- p.Ser422= Single submitter
Likely benign 9
- c.1272+9A>T Single submitter
- c.511-8G>A Single submitter
- p.Gly50Ala Single submitter ⚠
- p.Ile11= Single submitter
- p.Ile162= Single submitter
- p.Phe107Leu Single submitter
- p.Pro488= Single submitter
- p.Pro54Ser Single submitter ⚠
- p.Val164Ile Single submitter
Uncertain significance 59
- p.Ala149Pro Single submitter ⚠
- p.Ala401Gly Single submitter ⚠
- p.Ala423Thr Single submitter ⚠
- p.Ala429Gly Single submitter ⚠
- p.Ala464Val Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Arg267Gln Single submitter ⚠
- p.Arg398Cys Single submitter ⚠
- p.Arg398Leu Single submitter ⚠
- p.Arg454His Single submitter
- p.Arg463Gln Single submitter ⚠
- p.Arg463Trp Single submitter ⚠
- p.Arg87His Single submitter ⚠
- p.Asn409Ser Single submitter ⚠
- p.Gln254His Single submitter ⚠
- p.Gln281His Single submitter ⚠
- p.Glu259Gly Single submitter ⚠
- p.Glu482Gln Single submitter ⚠
- p.Glu487Lys Single submitter ⚠
- p.Gly361Glu Single submitter ⚠
- p.Gly479Ser Single submitter ⚠
- p.Gly77Arg Single submitter ⚠
- p.Ile214Met Single submitter ⚠
- p.Ile214Thr Single submitter ⚠
- p.Ile271Thr Single submitter
- p.Ile271Val Single submitter ⚠
- p.Ile274Thr Single submitter
- p.Ile370Thr Single submitter
- p.Ile388Thr Single submitter ⚠
- p.Ile388Val Single submitter ⚠
- p.Leu125Val Single submitter ⚠
- p.Leu178Val Single submitter
- p.Leu186Gln Single submitter
- p.Leu276Phe Single submitter ⚠
- p.Lys112Glu Single submitter ⚠
- p.Lys44Thr Single submitter ⚠
- p.Lys490Thr Single submitter ⚠
- p.Met249Val Single submitter ⚠
- p.Met402Val Single submitter ⚠
- p.Met483Ile Single submitter ⚠
- p.Met94Val Single submitter ⚠
- p.Phe137Leu Single submitter ⚠
- p.Phe176Leu Single submitter ⚠
- p.Phe344Leu Single submitter ⚠
- p.Phe376Cys Single submitter ⚠
- p.Phe387Ile Single submitter ⚠
- p.Phe442Val Single submitter ⚠
- p.Pro147Ser Single submitter ⚠
- p.Pro185Leu Single submitter ⚠
- p.Pro206Thr Single submitter ⚠
- p.Pro209Thr Single submitter ⚠
- p.Pro421Leu Single submitter ⚠
- p.Thr156Ser Single submitter
- p.Thr232Ala Single submitter ⚠
- p.Thr333Ile Single submitter ⚠
- p.Thr60Met Single submitter ⚠
- p.Tyr430His Single submitter
- p.Val320Ile Single submitter ⚠
- p.Val72Ile Single submitter ⚠