SLC2A4 — 57 ClinVar variants
All ClinVar germline SLC2A4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
1 Conflicting · 1 Benign · 5 Likely benign · 50 Uncertain significance
Full SLC2A4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
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SLC2A4 p.Val383Ile
Conflicting
Single submitter
type 2 diabetes mellitus
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC2A4 p.Ala251Ser Uncertain significance Single submitter
- SLC2A4 p.Ala347Val Uncertain significance Single submitter
- SLC2A4 p.Ala454Val Uncertain significance Single submitter
- SLC2A4 p.Arg110Ser Uncertain significance Single submitter
- SLC2A4 p.Arg228Cys Uncertain significance Single submitter
- SLC2A4 p.Arg246His Uncertain significance Single submitter
- SLC2A4 p.Arg269Cys Uncertain significance Single submitter
- SLC2A4 p.Arg271Gln Uncertain significance Single submitter
- SLC2A4 p.Arg376Gln Uncertain significance Single submitter
- SLC2A4 p.Arg474Gln Uncertain significance Single submitter
- SLC2A4 p.Arg485Gln Uncertain significance Single submitter
- SLC2A4 p.Asn304Asp Uncertain significance Single submitter
- SLC2A4 p.Gln234Glu Uncertain significance Single submitter
- SLC2A4 p.Glu225Lys Uncertain significance Single submitter
- SLC2A4 p.Glu409Lys Uncertain significance Single submitter
- SLC2A4 p.Glu67Ala Uncertain significance Single submitter
- SLC2A4 p.Gly328Arg Uncertain significance Single submitter
- SLC2A4 p.Gly75Asp Uncertain significance Single submitter
- SLC2A4 p.Ile145Phe Uncertain significance Single submitter
- SLC2A4 p.Ile388Met Uncertain significance Single submitter
- SLC2A4 p.Ile8Met Uncertain significance Single submitter
- SLC2A4 p.Leu342Val Uncertain significance Single submitter
- SLC2A4 p.Leu451Pro Uncertain significance Single submitter
- SLC2A4 p.Leu456Phe Uncertain significance Single submitter
- SLC2A4 p.Leu98Phe Uncertain significance Single submitter
- SLC2A4 p.Met360Ile Uncertain significance Single submitter
- SLC2A4 p.Pro15Ala Uncertain significance Single submitter
- SLC2A4 p.Pro378Ser Uncertain significance Single submitter
- SLC2A4 p.Pro487Ser Uncertain significance Single submitter
- SLC2A4 p.Thr351Met Uncertain significance Single submitter
- SLC2A4 p.Thr464Ile Uncertain significance Single submitter
- SLC2A4 p.Trp404Ser Uncertain significance Single submitter
- SLC2A4 p.Val319Ile Uncertain significance Single submitter
- SLC2A4 p.Val331Ala Uncertain significance Single submitter
- SLC2A4 p.Val468Ala Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- SLC2A4 p.Ala171Thr Uncertain significance Single submitter
- SLC2A4 p.Arg282Cys Uncertain significance Single submitter
- SLC2A4 p.Arg285Gln Uncertain significance Single submitter
- SLC2A4 p.Arg285Trp Uncertain significance Single submitter
- SLC2A4 p.Arg346Trp Uncertain significance Single submitter
- SLC2A4 p.Glu237Lys Uncertain significance Single submitter
- SLC2A4 p.Ile433Ser Uncertain significance Single submitter
- SLC2A4 p.Met367Lys Uncertain significance Single submitter
- SLC2A4 p.Tyr324Ser Uncertain significance Single submitter
- SLC2A4 p.Val293Met Uncertain significance Single submitter
All SLC2A4 variants
Conflicting classifications of pathogenicity 1
- p.Val383Ile Single submitter type 2 diabetes mellitus ⚠
Benign 1
- p.Ile186= Multiple submitters
Likely benign 5
- c.448+3A>T Single submitter
- p.Ala358Val Single submitter
- p.Arg282His Single submitter
- p.Thr79Ser Single submitter
- p.Val117Ile Single submitter
Uncertain significance 50
- p.Ala119Val Single submitter
- p.Ala164Thr Single submitter
- p.Ala171Thr Single submitter ⚠
- p.Ala251Ser Single submitter ⚠
- p.Ala347Val Single submitter ⚠
- p.Ala454Val Single submitter ⚠
- p.Arg110Ser Single submitter ⚠
- p.Arg228Cys Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg269Cys Single submitter ⚠
- p.Arg271Gln Single submitter ⚠
- p.Arg282Cys Single submitter ⚠
- p.Arg285Gln Single submitter ⚠
- p.Arg285Trp Single submitter ⚠
- p.Arg346Trp Single submitter ⚠
- p.Arg376Gln Single submitter ⚠
- p.Arg474Gln Single submitter ⚠
- p.Arg485Gln Single submitter ⚠
- p.Asn304Asp Single submitter ⚠
- p.Gln234Glu Single submitter ⚠
- p.Glu225Lys Single submitter ⚠
- p.Glu237Lys Single submitter ⚠
- p.Glu409Lys Single submitter ⚠
- p.Glu67Ala Single submitter ⚠
- p.Gly328Arg Single submitter ⚠
- p.Gly75Asp Single submitter ⚠
- p.Ile145Phe Single submitter ⚠
- p.Ile388Met Single submitter ⚠
- p.Ile433Ser Single submitter ⚠
- p.Ile8Met Single submitter ⚠
- p.Leu192Phe Single submitter
- p.Leu342Val Single submitter ⚠
- p.Leu451Pro Single submitter ⚠
- p.Leu456Phe Single submitter ⚠
- p.Leu98Phe Single submitter ⚠
- p.Met360Ile Single submitter ⚠
- p.Met367Lys Single submitter ⚠
- p.Pro15Ala Single submitter ⚠
- p.Pro378Ser Single submitter ⚠
- p.Pro487Ser Single submitter ⚠
- p.Thr351Met Single submitter ⚠
- p.Thr464Ile Single submitter ⚠
- p.Trp404Ser Single submitter ⚠
- p.Tyr324Ser Single submitter ⚠
- p.Val160Met Single submitter
- p.Val293Met Single submitter ⚠
- p.Val319Ile Single submitter ⚠
- p.Val331Ala Single submitter ⚠
- p.Val468Ala Single submitter ⚠
- p.Val51Ala Single submitter