SLC30A6 — 67 ClinVar variants
All ClinVar germline SLC30A6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
5 Likely benign · 62 Uncertain significance
Full SLC30A6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC30A6 p.Ala209Thr Uncertain significance Single submitter
- SLC30A6 p.Ala296Val Uncertain significance Single submitter
- SLC30A6 p.Arg156Gln Uncertain significance Single submitter
- SLC30A6 p.Arg20Trp Uncertain significance Single submitter
- SLC30A6 p.Arg29Gln Uncertain significance Single submitter
- SLC30A6 p.Arg29Gly Uncertain significance Single submitter
- SLC30A6 p.Arg460Thr Uncertain significance Single submitter
- SLC30A6 p.Asn222Asp Uncertain significance Single submitter
- SLC30A6 p.Asn349Ser Uncertain significance Single submitter
- SLC30A6 p.Asn414Ser Uncertain significance Single submitter
- SLC30A6 p.Asn453Ser Uncertain significance Single submitter
- SLC30A6 p.Asn56Asp Uncertain significance Single submitter
- SLC30A6 p.Cys213Phe Uncertain significance Single submitter
- SLC30A6 p.Ile270Leu Uncertain significance Single submitter
- SLC30A6 p.Ile4Phe Uncertain significance Single submitter
- SLC30A6 p.Ile79Val Uncertain significance Single submitter
- SLC30A6 p.Leu212Val Uncertain significance Single submitter
- SLC30A6 p.Leu342Phe Uncertain significance Single submitter
- SLC30A6 p.Leu402Val Uncertain significance Single submitter
- SLC30A6 p.Leu428Val Uncertain significance Single submitter
- SLC30A6 p.Lys365Glu Uncertain significance Single submitter
- SLC30A6 p.Met198Val Uncertain significance Single submitter
- SLC30A6 p.Met361Lys Uncertain significance Single submitter
- SLC30A6 p.Phe142Ser Uncertain significance Single submitter
- SLC30A6 p.Phe150Leu Uncertain significance Single submitter
- SLC30A6 p.Phe332Leu Uncertain significance Single submitter
- SLC30A6 p.Pro380Ser Uncertain significance Single submitter
- SLC30A6 p.Pro431Leu Uncertain significance Single submitter
- SLC30A6 p.Pro90Ser Uncertain significance Single submitter
- SLC30A6 p.Ser53Asn Uncertain significance Single submitter
- SLC30A6 p.Thr151Met Uncertain significance Single submitter
- SLC30A6 p.Thr169Ala Uncertain significance Single submitter
- SLC30A6 p.Thr258Pro Uncertain significance Single submitter
- SLC30A6 p.Thr275Ile Uncertain significance Single submitter
- SLC30A6 p.Thr289Ser Uncertain significance Single submitter
- SLC30A6 p.Thr406Lys Uncertain significance Single submitter
- SLC30A6 p.Thr418Ile Uncertain significance Single submitter
- SLC30A6 p.Trp288Cys Uncertain significance Single submitter
- SLC30A6 p.Tyr63Cys Uncertain significance Single submitter
- SLC30A6 p.Val227Ile Uncertain significance Single submitter
- SLC30A6 p.Val350Leu Uncertain significance Single submitter
- SLC30A6 p.Val91Phe Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- SLC30A6 p.Arg156Trp Uncertain significance Single submitter
- SLC30A6 p.Asn318Asp Uncertain significance Single submitter
- SLC30A6 p.Asn349Ile Uncertain significance Single submitter
- SLC30A6 p.Cys44Arg Uncertain significance Single submitter
- SLC30A6 p.Gly293Ala Uncertain significance Single submitter
- SLC30A6 p.Leu254Phe Uncertain significance Single submitter
- SLC30A6 p.Phe194Leu Uncertain significance Single submitter
- SLC30A6 p.Phe72Leu Uncertain significance Single submitter
- SLC30A6 p.Pro188Ala Uncertain significance Single submitter
- SLC30A6 p.Pro188Leu Uncertain significance Single submitter
- SLC30A6 p.Pro392Leu Uncertain significance Single submitter
- SLC30A6 p.Thr141Ile Uncertain significance Single submitter
All SLC30A6 variants
Likely benign 5
- p.Arg20Gln Single submitter
- p.Gly95= Single submitter
- p.Met75Ile Single submitter
- p.Thr367Ala Single submitter
- p.Val358Ile Single submitter
Uncertain significance 62
- p.Ala209Thr Single submitter ⚠
- p.Ala296Val Single submitter ⚠
- p.Arg156Gln Single submitter ⚠
- p.Arg156Trp Single submitter ⚠
- p.Arg197Gln Single submitter
- p.Arg20Trp Single submitter ⚠
- p.Arg283Gln Single submitter
- p.Arg29Gln Single submitter ⚠
- p.Arg29Gly Single submitter ⚠
- p.Arg460Thr Single submitter ⚠
- p.Asn222Asp Single submitter ⚠
- p.Asn318Asp Single submitter ⚠
- p.Asn349Ile Single submitter ⚠
- p.Asn349Ser Single submitter ⚠
- p.Asn414Ser Single submitter ⚠
- p.Asn453Ser Single submitter ⚠
- p.Asn56Asp Single submitter ⚠
- p.Cys213Phe Single submitter ⚠
- p.Cys44Arg Single submitter ⚠
- p.Glu386Lys Single submitter
- p.Gly293Ala Single submitter ⚠
- p.His133Tyr Single submitter
- p.Ile204Thr Single submitter
- p.Ile270Leu Single submitter ⚠
- p.Ile4Phe Single submitter ⚠
- p.Ile79Val Single submitter ⚠
- p.Leu212Val Single submitter ⚠
- p.Leu254Phe Single submitter ⚠
- p.Leu342Phe Single submitter ⚠
- p.Leu402Val Single submitter ⚠
- p.Leu428Val Single submitter ⚠
- p.Lys365Glu Single submitter ⚠
- p.Met198Val Single submitter ⚠
- p.Met246Val Single submitter
- p.Met361Lys Single submitter ⚠
- p.Phe142Ser Single submitter ⚠
- p.Phe150Leu Single submitter ⚠
- p.Phe194Leu Single submitter ⚠
- p.Phe332Leu Single submitter ⚠
- p.Phe72Leu Single submitter ⚠
- p.Pro188Ala Single submitter ⚠
- p.Pro188Leu Single submitter ⚠
- p.Pro380Ser Single submitter ⚠
- p.Pro392Leu Single submitter ⚠
- p.Pro431Leu Single submitter ⚠
- p.Pro90Ser Single submitter ⚠
- p.Ser154Tyr Single submitter
- p.Ser53Asn Single submitter ⚠
- p.Thr141Ile Single submitter ⚠
- p.Thr151Met Single submitter ⚠
- p.Thr169Ala Single submitter ⚠
- p.Thr258Pro Single submitter ⚠
- p.Thr275Ile Single submitter ⚠
- p.Thr289Ser Single submitter ⚠
- p.Thr406Lys Single submitter ⚠
- p.Thr418Ile Single submitter ⚠
- p.Trp288Cys Single submitter ⚠
- p.Tyr63Cys Single submitter ⚠
- p.Tyr92His Single submitter
- p.Val227Ile Single submitter ⚠
- p.Val350Leu Single submitter ⚠
- p.Val91Phe Single submitter ⚠