SLC35E1 — 48 ClinVar variants
All ClinVar germline SLC35E1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Likely benign · 47 Uncertain significance
Full SLC35E1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC35E1 p.Val128Ile Uncertain significance Multiple submitters
- SLC35E1 p.Ala196Val Uncertain significance Single submitter
- SLC35E1 p.Ala279Thr Uncertain significance Single submitter
- SLC35E1 p.Ala28Val Uncertain significance Single submitter
- SLC35E1 p.Ala4Ser Uncertain significance Single submitter
- SLC35E1 p.Ala54Asp Uncertain significance Single submitter
- SLC35E1 p.Arg344Gly Uncertain significance Single submitter
- SLC35E1 p.Arg360Cys Uncertain significance Single submitter
- SLC35E1 p.Arg362Trp Uncertain significance Single submitter
- SLC35E1 p.Arg384Cys Uncertain significance Single submitter
- SLC35E1 p.Asn295Ser Uncertain significance Single submitter
- SLC35E1 p.Asn406Lys Uncertain significance Single submitter
- SLC35E1 p.Asp338Asn Uncertain significance Single submitter
- SLC35E1 p.Gln381Glu Uncertain significance Single submitter
- SLC35E1 p.Gln393Arg Uncertain significance Single submitter
- SLC35E1 p.Glu183Gly Uncertain significance Single submitter
- SLC35E1 p.Gly14Asp Uncertain significance Single submitter
- SLC35E1 p.Gly371Ser Uncertain significance Single submitter
- SLC35E1 p.Gly378Arg Uncertain significance Single submitter
- SLC35E1 p.Gly7Arg Uncertain significance Single submitter
- SLC35E1 p.His361Tyr Uncertain significance Single submitter
- SLC35E1 p.His369Tyr Uncertain significance Single submitter
- SLC35E1 p.His377Gln Uncertain significance Single submitter
- SLC35E1 p.Ile173Val Uncertain significance Single submitter
- SLC35E1 p.Ile387Val Uncertain significance Single submitter
- SLC35E1 p.Leu102Gln Uncertain significance Single submitter
- SLC35E1 p.Leu151Phe Uncertain significance Single submitter
- SLC35E1 p.Lys334Glu Uncertain significance Single submitter
- SLC35E1 p.Phe201Cys Uncertain significance Single submitter
- SLC35E1 p.Pro109Ala Uncertain significance Single submitter
- SLC35E1 p.Pro114Leu Uncertain significance Single submitter
- SLC35E1 p.Ser395Gly Uncertain significance Single submitter
- SLC35E1 p.Trp131Arg Uncertain significance Single submitter
- SLC35E1 p.Trp238Arg Uncertain significance Single submitter
- SLC35E1 p.Tyr137Ser Uncertain significance Single submitter
- SLC35E1 p.Tyr254Ser Uncertain significance Single submitter
- SLC35E1 p.Val181Ile Uncertain significance Single submitter
- SLC35E1 p.Val255Ile Uncertain significance Single submitter
- SLC35E1 p.Val293Ile Uncertain significance Single submitter
- SLC35E1 p.Val302Phe Uncertain significance Single submitter
- SLC35E1 p.Val319Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- SLC35E1 p.Cys34Phe Uncertain significance Single submitter
- SLC35E1 p.Gly269Ser Uncertain significance Single submitter
- SLC35E1 p.Ile130Thr Uncertain significance Single submitter
- SLC35E1 p.Ile155Thr Uncertain significance Single submitter
- SLC35E1 p.Phe117Leu Uncertain significance Single submitter
- SLC35E1 p.Phe233Leu Uncertain significance Single submitter
All SLC35E1 variants
Likely benign 1
- p.Ser99Pro Single submitter
Uncertain significance 47
- p.Val128Ile Multiple submitters ⚠
- p.Ala196Val Single submitter ⚠
- p.Ala279Thr Single submitter ⚠
- p.Ala28Val Single submitter ⚠
- p.Ala4Ser Single submitter ⚠
- p.Ala54Asp Single submitter ⚠
- p.Arg344Gly Single submitter ⚠
- p.Arg360Cys Single submitter ⚠
- p.Arg362Trp Single submitter ⚠
- p.Arg384Cys Single submitter ⚠
- p.Asn295Ser Single submitter ⚠
- p.Asn406Lys Single submitter ⚠
- p.Asp338Asn Single submitter ⚠
- p.Cys34Phe Single submitter ⚠
- p.Gln381Glu Single submitter ⚠
- p.Gln393Arg Single submitter ⚠
- p.Glu183Gly Single submitter ⚠
- p.Gly14Asp Single submitter ⚠
- p.Gly269Ser Single submitter ⚠
- p.Gly371Ser Single submitter ⚠
- p.Gly378Arg Single submitter ⚠
- p.Gly7Arg Single submitter ⚠
- p.His361Tyr Single submitter ⚠
- p.His369Tyr Single submitter ⚠
- p.His377Gln Single submitter ⚠
- p.Ile130Thr Single submitter ⚠
- p.Ile155Thr Single submitter ⚠
- p.Ile173Val Single submitter ⚠
- p.Ile387Val Single submitter ⚠
- p.Leu102Gln Single submitter ⚠
- p.Leu151Phe Single submitter ⚠
- p.Lys334Glu Single submitter ⚠
- p.Phe117Leu Single submitter ⚠
- p.Phe201Cys Single submitter ⚠
- p.Phe233Leu Single submitter ⚠
- p.Pro109Ala Single submitter ⚠
- p.Pro114Leu Single submitter ⚠
- p.Ser395Gly Single submitter ⚠
- p.Trp131Arg Single submitter ⚠
- p.Trp238Arg Single submitter ⚠
- p.Tyr137Ser Single submitter ⚠
- p.Tyr254Ser Single submitter ⚠
- p.Val181Ile Single submitter ⚠
- p.Val255Ile Single submitter ⚠
- p.Val293Ile Single submitter ⚠
- p.Val302Phe Single submitter ⚠
- p.Val319Ile Single submitter ⚠