SLC6A15 — 79 ClinVar variants
All ClinVar germline SLC6A15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
2 Benign · 2 Likely benign · 75 Uncertain significance
Full SLC6A15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC6A15 p.Ala33Thr Uncertain significance Single submitter
- SLC6A15 p.Ala360Glu Uncertain significance Single submitter
- SLC6A15 p.Ala435Thr Uncertain significance Single submitter
- SLC6A15 p.Ala442Gly Uncertain significance Single submitter
- SLC6A15 p.Ala455Thr Uncertain significance Single submitter
- SLC6A15 p.Ala719Gly Uncertain significance Single submitter
- SLC6A15 p.Arg126Trp Uncertain significance Single submitter
- SLC6A15 p.Arg640His Uncertain significance Single submitter
- SLC6A15 p.Asn643Ser Uncertain significance Single submitter
- SLC6A15 p.Asn709Ser Uncertain significance Single submitter
- SLC6A15 p.Asn94Ser Uncertain significance Single submitter
- SLC6A15 p.Asp13Gly Uncertain significance Single submitter
- SLC6A15 p.Asp15Gly Uncertain significance Single submitter
- SLC6A15 p.Asp180Asn Uncertain significance Single submitter
- SLC6A15 p.Asp559Tyr Uncertain significance Single submitter
- SLC6A15 p.Asp646Gly Uncertain significance Single submitter
- SLC6A15 p.Cys501Ser Uncertain significance Single submitter
- SLC6A15 p.Glu555Gly Uncertain significance Single submitter
- SLC6A15 p.Glu684Lys Uncertain significance Single submitter
- SLC6A15 p.Gly313Arg Uncertain significance Single submitter
- SLC6A15 p.Gly357Ala Uncertain significance Single submitter
- SLC6A15 p.Gly562Ser Uncertain significance Single submitter
- SLC6A15 p.Gly671Asp Uncertain significance Single submitter
- SLC6A15 p.Ile105Val Uncertain significance Single submitter
- SLC6A15 p.Ile279Thr Uncertain significance Single submitter
- SLC6A15 p.Ile318Thr Uncertain significance Single submitter
- SLC6A15 p.Ile428Thr Uncertain significance Single submitter
- SLC6A15 p.Ile508Phe Uncertain significance Single submitter
- SLC6A15 p.Ile511Leu Uncertain significance Single submitter
- SLC6A15 p.Ile542Thr Uncertain significance Single submitter
- SLC6A15 p.Ile638Leu Uncertain significance Single submitter
- SLC6A15 p.Ile714Thr Uncertain significance Single submitter
- SLC6A15 p.Leu259Val Uncertain significance Single submitter
- SLC6A15 p.Leu405Phe Uncertain significance Single submitter
- SLC6A15 p.Leu421Arg Uncertain significance Single submitter
- SLC6A15 p.Leu704Pro Uncertain significance Single submitter
- SLC6A15 p.Met108Val Uncertain significance Single submitter
- SLC6A15 p.Met243Val Uncertain significance Single submitter
- SLC6A15 p.Met376Leu Uncertain significance Single submitter
- SLC6A15 p.Met376Val Uncertain significance Single submitter
- SLC6A15 p.Met523Leu Uncertain significance Single submitter
- SLC6A15 p.Met572Thr Uncertain significance Single submitter
- SLC6A15 p.Met722Thr Uncertain significance Single submitter
- SLC6A15 p.Met725Ile Uncertain significance Single submitter
- SLC6A15 p.Phe286Cys Uncertain significance Single submitter
- SLC6A15 p.Pro596Leu Uncertain significance Single submitter
- SLC6A15 p.Pro597Ser Uncertain significance Single submitter
- SLC6A15 p.Pro666Arg Uncertain significance Single submitter
- SLC6A15 p.Pro682Leu Uncertain significance Single submitter
- SLC6A15 p.Pro723Ser Uncertain significance Single submitter
- SLC6A15 p.Ser170Ala Uncertain significance Single submitter
- SLC6A15 p.Thr229Ala Uncertain significance Single submitter
- SLC6A15 p.Thr397Asn Uncertain significance Single submitter
- SLC6A15 p.Thr397Ser Uncertain significance Single submitter
- SLC6A15 p.Thr447Ile Uncertain significance Single submitter
- SLC6A15 p.Thr49Lys Uncertain significance Single submitter
- SLC6A15 p.Thr703Ile Uncertain significance Single submitter
- SLC6A15 p.Val109Ile Uncertain significance Single submitter
- SLC6A15 p.Val436Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- SLC6A15 p.Ala449Val Uncertain significance Single submitter
- SLC6A15 p.Asn394Lys Uncertain significance Single submitter
- SLC6A15 p.Gln171Leu Uncertain significance Single submitter
- SLC6A15 p.Glu417Lys Uncertain significance Single submitter
- SLC6A15 p.Leu100Ile Uncertain significance Single submitter
- SLC6A15 p.Lys552Glu Uncertain significance Single submitter
- SLC6A15 p.Thr304Ile Uncertain significance Single submitter
- SLC6A15 p.Thr484Ser Uncertain significance Single submitter
- SLC6A15 p.Val306Leu Uncertain significance Single submitter
All SLC6A15 variants
Likely benign 2
- p.Gln370= Single submitter
- p.Phe378Leu Single submitter
Uncertain significance 75
- p.Ala33Thr Single submitter ⚠
- p.Ala360Glu Single submitter ⚠
- p.Ala435Thr Single submitter ⚠
- p.Ala442Gly Single submitter ⚠
- p.Ala449Val Single submitter ⚠
- p.Ala455Thr Single submitter ⚠
- p.Ala719Gly Single submitter ⚠
- p.Arg126Trp Single submitter ⚠
- p.Arg640His Single submitter ⚠
- p.Asn394Lys Single submitter ⚠
- p.Asn643Ser Single submitter ⚠
- p.Asn709Ser Single submitter ⚠
- p.Asn94Ser Single submitter ⚠
- p.Asp13Gly Single submitter ⚠
- p.Asp15Gly Single submitter ⚠
- p.Asp180Asn Single submitter ⚠
- p.Asp559Tyr Single submitter ⚠
- p.Asp646Gly Single submitter ⚠
- p.Asp729Val Single submitter
- p.Cys501Ser Single submitter ⚠
- p.Gln171Leu Single submitter ⚠
- p.Glu417Lys Single submitter ⚠
- p.Glu555Gly Single submitter ⚠
- p.Glu684Lys Single submitter ⚠
- p.Gly313Arg Single submitter ⚠
- p.Gly357Ala Single submitter ⚠
- p.Gly562Ser Single submitter ⚠
- p.Gly671Asp Single submitter ⚠
- p.Ile105Val Single submitter ⚠
- p.Ile247Val Single submitter
- p.Ile279Thr Single submitter ⚠
- p.Ile318Thr Single submitter ⚠
- p.Ile428Thr Single submitter ⚠
- p.Ile508Phe Single submitter ⚠
- p.Ile511Leu Single submitter ⚠
- p.Ile542Thr Single submitter ⚠
- p.Ile638Leu Single submitter ⚠
- p.Ile714Thr Single submitter ⚠
- p.Leu100Ile Single submitter ⚠
- p.Leu259Val Single submitter ⚠
- p.Leu405Phe Single submitter ⚠
- p.Leu421Arg Single submitter ⚠
- p.Leu644His Single submitter
- p.Leu663Pro Single submitter
- p.Leu704Pro Single submitter ⚠
- p.Lys552Glu Single submitter ⚠
- p.Met108Val Single submitter ⚠
- p.Met243Val Single submitter ⚠
- p.Met285Leu Single submitter
- p.Met376Leu Single submitter ⚠
- p.Met376Val Single submitter ⚠
- p.Met523Leu Single submitter ⚠
- p.Met572Thr Single submitter ⚠
- p.Met722Thr Single submitter ⚠
- p.Met725Ile Single submitter ⚠
- p.Phe286Cys Single submitter ⚠
- p.Pro596Leu Single submitter ⚠
- p.Pro597Ser Single submitter ⚠
- p.Pro666Arg Single submitter ⚠
- p.Pro682Leu Single submitter ⚠
- p.Pro723Ser Single submitter ⚠
- p.Ser170Ala Single submitter ⚠
- p.Ser683Arg Single submitter
- p.Thr229Ala Single submitter ⚠
- p.Thr304Ile Single submitter ⚠
- p.Thr397Asn Single submitter ⚠
- p.Thr397Ser Single submitter ⚠
- p.Thr447Ile Single submitter ⚠
- p.Thr484Ser Single submitter ⚠
- p.Thr49Lys Single submitter ⚠
- p.Thr703Ile Single submitter ⚠
- p.Val109Ile Single submitter ⚠
- p.Val306Leu Single submitter ⚠
- p.Val436Ile Single submitter ⚠
- p.Val655Ala Single submitter