SLC9A2 — 72 ClinVar variants
All ClinVar germline SLC9A2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
4 Likely benign · 68 Uncertain significance
Full SLC9A2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC9A2 p.Ala26Glu Uncertain significance Single submitter
- SLC9A2 p.Ala39Thr Uncertain significance Single submitter
- SLC9A2 p.Ala406Val Uncertain significance Single submitter
- SLC9A2 p.Ala42Asp Uncertain significance Single submitter
- SLC9A2 p.Ala444Val Uncertain significance Single submitter
- SLC9A2 p.Ala497Thr Uncertain significance Single submitter
- SLC9A2 p.Ala53Val Uncertain significance Single submitter
- SLC9A2 p.Ala564Asp Uncertain significance Single submitter
- SLC9A2 p.Ala564Thr Uncertain significance Single submitter
- SLC9A2 p.Ala700Val Uncertain significance Single submitter
- SLC9A2 p.Arg456Gln Uncertain significance Single submitter
- SLC9A2 p.Arg586Cys Uncertain significance Single submitter
- SLC9A2 p.Arg586His Uncertain significance Single submitter
- SLC9A2 p.Arg615Gln Uncertain significance Single submitter
- SLC9A2 p.Arg656Gln Uncertain significance Single submitter
- SLC9A2 p.Arg656Leu Uncertain significance Single submitter
- SLC9A2 p.Arg67Gly Uncertain significance Single submitter
- SLC9A2 p.Arg710Thr Uncertain significance Single submitter
- SLC9A2 p.Arg713Leu Uncertain significance Single submitter
- SLC9A2 p.Arg796Thr Uncertain significance Single submitter
- SLC9A2 p.Arg803Gln Uncertain significance Single submitter
- SLC9A2 p.Asn492Ser Uncertain significance Single submitter
- SLC9A2 p.Asp201Asn Uncertain significance Single submitter
- SLC9A2 p.Asp736His Uncertain significance Single submitter
- SLC9A2 p.Gln495Lys Uncertain significance Single submitter
- SLC9A2 p.Glu810Gln Uncertain significance Single submitter
- SLC9A2 p.Gly154Ser Uncertain significance Single submitter
- SLC9A2 p.Gly59Glu Uncertain significance Single submitter
- SLC9A2 p.Gly761Ala Uncertain significance Single submitter
- SLC9A2 p.Ile115Thr Uncertain significance Single submitter
- SLC9A2 p.Ile182Thr Uncertain significance Single submitter
- SLC9A2 p.Ile237Thr Uncertain significance Single submitter
- SLC9A2 p.Leu36Met Uncertain significance Single submitter
- SLC9A2 p.Leu654Phe Uncertain significance Single submitter
- SLC9A2 p.Leu767Arg Uncertain significance Single submitter
- SLC9A2 p.Leu781Val Uncertain significance Single submitter
- SLC9A2 p.Lys770Glu Uncertain significance Single submitter
- SLC9A2 p.Met116Thr Uncertain significance Single submitter
- SLC9A2 p.Pro16Leu Uncertain significance Single submitter
- SLC9A2 p.Pro28Leu Uncertain significance Single submitter
- SLC9A2 p.Pro28Ser Uncertain significance Single submitter
- SLC9A2 p.Pro748Gln Uncertain significance Single submitter
- SLC9A2 p.Pro748Ser Uncertain significance Single submitter
- SLC9A2 p.Ser46Thr Uncertain significance Single submitter
- SLC9A2 p.Ser54Thr Uncertain significance Single submitter
- SLC9A2 p.Ser647Gly Uncertain significance Single submitter
- SLC9A2 p.Ser696Pro Uncertain significance Single submitter
- SLC9A2 p.Ser723Tyr Uncertain significance Single submitter
- SLC9A2 p.Ser739Ala Uncertain significance Single submitter
- SLC9A2 p.Thr337Ser Uncertain significance Single submitter
- SLC9A2 p.Thr397Asn Uncertain significance Single submitter
- SLC9A2 p.Thr702Ser Uncertain significance Single submitter
- SLC9A2 p.Thr746Asn Uncertain significance Single submitter
- SLC9A2 p.Thr746Ile Uncertain significance Single submitter
- SLC9A2 p.Val394Ile Uncertain significance Single submitter
- SLC9A2 p.Val453Met Uncertain significance Single submitter
- SLC9A2 p.Val483Met Uncertain significance Single submitter
- SLC9A2 p.Val55Leu Uncertain significance Single submitter
- SLC9A2 p.Val55Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- SLC9A2 p.Arg792Trp Uncertain significance Single submitter
- SLC9A2 p.Glu388Lys Uncertain significance Single submitter
- SLC9A2 p.Gly384Asp Uncertain significance Single submitter
- SLC9A2 p.Leu18Arg Uncertain significance Single submitter
- SLC9A2 p.Ser491Pro Uncertain significance Single submitter
- SLC9A2 p.Ser554Phe Uncertain significance Single submitter
- SLC9A2 p.Trp731Arg Uncertain significance Single submitter
- SLC9A2 p.Val369Ala Uncertain significance Single submitter
All SLC9A2 variants
Likely benign 4
- p.Ala444= Single submitter
- p.Gly774Asp Single submitter
- p.Leu506= Single submitter
- p.Ser652Asn Single submitter
Uncertain significance 68
- p.Ala26Glu Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Ala406Val Single submitter ⚠
- p.Ala42Asp Single submitter ⚠
- p.Ala444Val Single submitter ⚠
- p.Ala497Thr Single submitter ⚠
- p.Ala53Val Single submitter ⚠
- p.Ala564Asp Single submitter ⚠
- p.Ala564Thr Single submitter ⚠
- p.Ala700Val Single submitter ⚠
- p.Arg456Gln Single submitter ⚠
- p.Arg586Cys Single submitter ⚠
- p.Arg586His Single submitter ⚠
- p.Arg615Gln Single submitter ⚠
- p.Arg656Gln Single submitter ⚠
- p.Arg656Leu Single submitter ⚠
- p.Arg67Gly Single submitter ⚠
- p.Arg710Thr Single submitter ⚠
- p.Arg713Leu Single submitter ⚠
- p.Arg792Trp Single submitter ⚠
- p.Arg796Thr Single submitter ⚠
- p.Arg803Gln Single submitter ⚠
- p.Asn492Ser Single submitter ⚠
- p.Asp201Asn Single submitter ⚠
- p.Asp736His Single submitter ⚠
- p.Gln495Lys Single submitter ⚠
- p.Glu388Lys Single submitter ⚠
- p.Glu810Gln Single submitter ⚠
- p.Gly154Ser Single submitter ⚠
- p.Gly384Asp Single submitter ⚠
- p.Gly59Glu Single submitter ⚠
- p.Gly761Ala Single submitter ⚠
- p.Ile115Thr Single submitter ⚠
- p.Ile182Thr Single submitter ⚠
- p.Ile237Thr Single submitter ⚠
- p.Leu18Arg Single submitter ⚠
- p.Leu36Met Single submitter ⚠
- p.Leu654Phe Single submitter ⚠
- p.Leu767Arg Single submitter ⚠
- p.Leu781Val Single submitter ⚠
- p.Lys770Glu Single submitter ⚠
- p.Met116Thr Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro28Ser Single submitter ⚠
- p.Pro748Gln Single submitter ⚠
- p.Pro748Ser Single submitter ⚠
- p.Ser46Thr Single submitter ⚠
- p.Ser491Pro Single submitter ⚠
- p.Ser54Thr Single submitter ⚠
- p.Ser554Phe Single submitter ⚠
- p.Ser647Gly Single submitter ⚠
- p.Ser696Pro Single submitter ⚠
- p.Ser723Tyr Single submitter ⚠
- p.Ser739Ala Single submitter ⚠
- p.Thr337Ser Single submitter ⚠
- p.Thr397Asn Single submitter ⚠
- p.Thr702Ser Single submitter ⚠
- p.Thr746Asn Single submitter ⚠
- p.Thr746Ile Single submitter ⚠
- p.Trp731Arg Single submitter ⚠
- p.Val369Ala Single submitter ⚠
- p.Val394Ile Single submitter ⚠
- p.Val453Met Single submitter ⚠
- p.Val483Met Single submitter ⚠
- p.Val55Leu Single submitter ⚠
- p.Val55Met Single submitter ⚠
- p.Gln725fs No assertion criteria acute megakaryoblastic leukemia