SLC9A5 — 119 ClinVar variants
All ClinVar germline SLC9A5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →
5 Likely benign · 114 Uncertain significance
Full SLC9A5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 108
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 93
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC9A5 p.Ala14Val Uncertain significance Single submitter
- SLC9A5 p.Ala16Gly Uncertain significance Single submitter
- SLC9A5 p.Ala183Val Uncertain significance Single submitter
- SLC9A5 p.Ala215Thr Uncertain significance Single submitter
- SLC9A5 p.Ala289Thr Uncertain significance Single submitter
- SLC9A5 p.Ala412Asp Uncertain significance Single submitter
- SLC9A5 p.Ala4Ser Uncertain significance Single submitter
- SLC9A5 p.Ala598Val Uncertain significance Single submitter
- SLC9A5 p.Ala676Val Uncertain significance Single submitter
- SLC9A5 p.Ala809Ser Uncertain significance Single submitter
- SLC9A5 p.Ala840Thr Uncertain significance Single submitter
- SLC9A5 p.Ala848Ser Uncertain significance Single submitter
- SLC9A5 p.Ala98Pro Uncertain significance Single submitter
- SLC9A5 p.Arg515Pro Uncertain significance Single submitter
- SLC9A5 p.Arg519Cys Uncertain significance Single submitter
- SLC9A5 p.Arg521Gln Uncertain significance Single submitter
- SLC9A5 p.Arg530Lys Uncertain significance Single submitter
- SLC9A5 p.Arg534Gln Uncertain significance Single submitter
- SLC9A5 p.Arg534Trp Uncertain significance Single submitter
- SLC9A5 p.Arg560Cys Uncertain significance Single submitter
- SLC9A5 p.Arg573Lys Uncertain significance Single submitter
- SLC9A5 p.Arg590Cys Uncertain significance Single submitter
- SLC9A5 p.Arg590His Uncertain significance Single submitter
- SLC9A5 p.Arg593Gln Uncertain significance Single submitter
- SLC9A5 p.Arg595His Uncertain significance Single submitter
- SLC9A5 p.Arg613His Uncertain significance Single submitter
- SLC9A5 p.Arg621His Uncertain significance Single submitter
- SLC9A5 p.Arg631Gln Uncertain significance Single submitter
- SLC9A5 p.Arg643Trp Uncertain significance Single submitter
- SLC9A5 p.Arg663Gln Uncertain significance Single submitter
- SLC9A5 p.Arg665Cys Uncertain significance Single submitter
- SLC9A5 p.Arg669His Uncertain significance Single submitter
- SLC9A5 p.Arg669Leu Uncertain significance Single submitter
- SLC9A5 p.Arg68Gly Uncertain significance Single submitter
- SLC9A5 p.Arg727His Uncertain significance Single submitter
- SLC9A5 p.Arg749Gln Uncertain significance Single submitter
- SLC9A5 p.Arg820Trp Uncertain significance Single submitter
- SLC9A5 p.Arg836His Uncertain significance Single submitter
- SLC9A5 p.Asn225Thr Uncertain significance Single submitter
- SLC9A5 p.Asp692Gly Uncertain significance Single submitter
- SLC9A5 p.Asp834Asn Uncertain significance Single submitter
- SLC9A5 p.Cys745Ser Uncertain significance Single submitter
- SLC9A5 p.Cys806Tyr Uncertain significance Single submitter
- SLC9A5 p.Glu279Gln Uncertain significance Single submitter
- SLC9A5 p.Glu823Asp Uncertain significance Single submitter
- SLC9A5 p.Glu99Gly Uncertain significance Single submitter
- SLC9A5 p.Gly33Asp Uncertain significance Single submitter
- SLC9A5 p.Gly736Arg Uncertain significance Single submitter
- SLC9A5 p.Gly821Asp Uncertain significance Single submitter
- SLC9A5 p.Gly821Val Uncertain significance Single submitter
- SLC9A5 p.His490Gln Uncertain significance Single submitter
- SLC9A5 p.Ile205Met Uncertain significance Single submitter
- SLC9A5 p.Ile278Val Uncertain significance Single submitter
- SLC9A5 p.Leu132Val Uncertain significance Single submitter
- SLC9A5 p.Leu176Pro Uncertain significance Single submitter
- SLC9A5 p.Leu202Val Uncertain significance Single submitter
- SLC9A5 p.Leu299Val Uncertain significance Single submitter
- SLC9A5 p.Leu733Phe Uncertain significance Single submitter
- SLC9A5 p.Leu79Pro Uncertain significance Single submitter
- SLC9A5 p.Lys423Glu Uncertain significance Single submitter
- SLC9A5 p.Lys652Arg Uncertain significance Single submitter
- SLC9A5 p.Met402Leu Uncertain significance Single submitter
- SLC9A5 p.Met557Val Uncertain significance Single submitter
- SLC9A5 p.Met787Thr Uncertain significance Single submitter
- SLC9A5 p.Met869Val Uncertain significance Single submitter
- SLC9A5 p.Phe477Ser Uncertain significance Single submitter
- SLC9A5 p.Pro27Leu Uncertain significance Single submitter
- SLC9A5 p.Pro664Ser Uncertain significance Single submitter
- SLC9A5 p.Pro753Arg Uncertain significance Single submitter
- SLC9A5 p.Pro832Arg Uncertain significance Single submitter
- SLC9A5 p.Ser324Thr Uncertain significance Single submitter
- SLC9A5 p.Ser461Asn Uncertain significance Single submitter
- SLC9A5 p.Ser766Arg Uncertain significance Single submitter
- SLC9A5 p.Ser878Gly Uncertain significance Single submitter
- SLC9A5 p.Thr238Ser Uncertain significance Single submitter
- SLC9A5 p.Thr441Ala Uncertain significance Single submitter
- SLC9A5 p.Thr550Ile Uncertain significance Single submitter
- SLC9A5 p.Thr651Ser Uncertain significance Single submitter
- SLC9A5 p.Thr756Ala Uncertain significance Single submitter
- SLC9A5 p.Thr883Ala Uncertain significance Single submitter
- SLC9A5 p.Thr883Ile Uncertain significance Single submitter
- SLC9A5 p.Trp359Arg Uncertain significance Single submitter
- SLC9A5 p.Val218Met Uncertain significance Single submitter
- SLC9A5 p.Val257Met Uncertain significance Single submitter
- SLC9A5 p.Val275Ile Uncertain significance Single submitter
- SLC9A5 p.Val342Met Uncertain significance Single submitter
- SLC9A5 p.Val438Ala Uncertain significance Single submitter
- SLC9A5 p.Val444Met Uncertain significance Single submitter
- SLC9A5 p.Val546Ile Uncertain significance Single submitter
- SLC9A5 p.Val563Met Uncertain significance Single submitter
- SLC9A5 p.Val732Ile Uncertain significance Single submitter
- SLC9A5 p.Val773Ala Uncertain significance Single submitter
- SLC9A5 p.Val86Ala Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- SLC9A5 p.Arg573Ser Uncertain significance Single submitter
- SLC9A5 p.Arg613Cys Uncertain significance Single submitter
- SLC9A5 p.Arg621Cys Uncertain significance Single submitter
- SLC9A5 p.Gly161Arg Uncertain significance Single submitter
- SLC9A5 p.His601Tyr Uncertain significance Single submitter
- SLC9A5 p.Leu531Val Uncertain significance Single submitter
- SLC9A5 p.Leu9Phe Uncertain significance Single submitter
- SLC9A5 p.Lys329Arg Uncertain significance Single submitter
- SLC9A5 p.Lys465Ile Uncertain significance Single submitter
- SLC9A5 p.Lys642Thr Uncertain significance Single submitter
- SLC9A5 p.Lys652Asn Uncertain significance Single submitter
- SLC9A5 p.Ser58Asn Uncertain significance Single submitter
- SLC9A5 p.Thr651Ile Uncertain significance Single submitter
- SLC9A5 p.Trp764Cys Uncertain significance Single submitter
- SLC9A5 p.Val198Ile Uncertain significance Single submitter
All SLC9A5 variants
Likely benign 5
- p.Ala579= Single submitter
- p.Arg852His Single submitter
- p.His818Arg Single submitter
- p.Pro819= Single submitter
- p.Ser894Gly Single submitter
Uncertain significance 114
- p.Ala14Val Single submitter ⚠
- p.Ala16Gly Single submitter ⚠
- p.Ala183Val Single submitter ⚠
- p.Ala215Thr Single submitter ⚠
- p.Ala289Thr Single submitter ⚠
- p.Ala412Asp Single submitter ⚠
- p.Ala4Ser Single submitter ⚠
- p.Ala598Val Single submitter ⚠
- p.Ala676Val Single submitter ⚠
- p.Ala809Ser Single submitter ⚠
- p.Ala840Thr Single submitter ⚠
- p.Ala848Ser Single submitter ⚠
- p.Ala98Pro Single submitter ⚠
- p.Arg276His Single submitter
- p.Arg515Pro Single submitter ⚠
- p.Arg519Cys Single submitter ⚠
- p.Arg521Gln Single submitter ⚠
- p.Arg530Lys Single submitter ⚠
- p.Arg534Gln Single submitter ⚠
- p.Arg534Trp Single submitter ⚠
- p.Arg560Cys Single submitter ⚠
- p.Arg573Lys Single submitter ⚠
- p.Arg573Ser Single submitter ⚠
- p.Arg590Cys Single submitter ⚠
- p.Arg590His Single submitter ⚠
- p.Arg593Gln Single submitter ⚠
- p.Arg595His Single submitter ⚠
- p.Arg613Cys Single submitter ⚠
- p.Arg613His Single submitter ⚠
- p.Arg621Cys Single submitter ⚠
- p.Arg621His Single submitter ⚠
- p.Arg631Gln Single submitter ⚠
- p.Arg643Trp Single submitter ⚠
- p.Arg663Gln Single submitter ⚠
- p.Arg665Cys Single submitter ⚠
- p.Arg669His Single submitter ⚠
- p.Arg669Leu Single submitter ⚠
- p.Arg68Gly Single submitter ⚠
- p.Arg727His Single submitter ⚠
- p.Arg749Gln Single submitter ⚠
- p.Arg820Trp Single submitter ⚠
- p.Arg836His Single submitter ⚠
- p.Asn225Thr Single submitter ⚠
- p.Asp692Gly Single submitter ⚠
- p.Asp834Asn Single submitter ⚠
- p.Cys745Ser Single submitter ⚠
- p.Cys806Tyr Single submitter ⚠
- p.Glu279Gln Single submitter ⚠
- p.Glu823Asp Single submitter ⚠
- p.Glu99Gly Single submitter ⚠
- p.Gly161Arg Single submitter ⚠
- p.Gly33Asp Single submitter ⚠
- p.Gly736Arg Single submitter ⚠
- p.Gly821Asp Single submitter ⚠
- p.Gly821Val Single submitter ⚠
- p.His490Gln Single submitter ⚠
- p.His601Tyr Single submitter ⚠
- p.Ile205Met Single submitter ⚠
- p.Ile278Val Single submitter ⚠
- p.Leu132Val Single submitter ⚠
- p.Leu176Pro Single submitter ⚠
- p.Leu202Val Single submitter ⚠
- p.Leu299Val Single submitter ⚠
- p.Leu531Val Single submitter ⚠
- p.Leu733Phe Single submitter ⚠
- p.Leu79Pro Single submitter ⚠
- p.Leu9Phe Single submitter ⚠
- p.Lys329Arg Single submitter ⚠
- p.Lys423Glu Single submitter ⚠
- p.Lys465Ile Single submitter ⚠
- p.Lys642Thr Single submitter ⚠
- p.Lys652Arg Single submitter ⚠
- p.Lys652Asn Single submitter ⚠
- p.Lys716del Single submitter
- p.Met402Leu Single submitter ⚠
- p.Met557Val Single submitter ⚠
- p.Met641Val Single submitter
- p.Met787Thr Single submitter ⚠
- p.Met869Val Single submitter ⚠
- p.Phe477Ser Single submitter ⚠
- p.Pro104Ser Single submitter
- p.Pro27Leu Single submitter ⚠
- p.Pro664Ser Single submitter ⚠
- p.Pro753Arg Single submitter ⚠
- p.Pro832Arg Single submitter ⚠
- p.Ser324Thr Single submitter ⚠
- p.Ser461Asn Single submitter ⚠
- p.Ser58Asn Single submitter ⚠
- p.Ser766Arg Single submitter ⚠
- p.Ser878Gly Single submitter ⚠
- p.Thr238Ser Single submitter ⚠
- p.Thr441Ala Single submitter ⚠
- p.Thr550Ile Single submitter ⚠
- p.Thr651Ile Single submitter ⚠
- p.Thr651Ser Single submitter ⚠
- p.Thr756Ala Single submitter ⚠
- p.Thr883Ala Single submitter ⚠
- p.Thr883Ile Single submitter ⚠
- p.Trp359Arg Single submitter ⚠
- p.Trp764Cys Single submitter ⚠
- p.Val198Ile Single submitter ⚠
- p.Val218Met Single submitter ⚠
- p.Val257Met Single submitter ⚠
- p.Val275Ile Single submitter ⚠
- p.Val342Met Single submitter ⚠
- p.Val352Met Single submitter
- p.Val416Ile Single submitter
- p.Val438Ala Single submitter ⚠
- p.Val444Met Single submitter ⚠
- p.Val546Ile Single submitter ⚠
- p.Val563Met Single submitter ⚠
- p.Val732Ile Single submitter ⚠
- p.Val773Ala Single submitter ⚠
- p.Val86Ala Single submitter ⚠