SLC9B2 — 78 ClinVar variants
All ClinVar germline SLC9B2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →
3 Benign · 75 Uncertain significance
Full SLC9B2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 74
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLC9B2 p.Ala180Val Uncertain significance Single submitter
- SLC9B2 p.Ala350Thr Uncertain significance Single submitter
- SLC9B2 p.Ala392Val Uncertain significance Single submitter
- SLC9B2 p.Ala456Val Uncertain significance Single submitter
- SLC9B2 p.Arg330His Uncertain significance Single submitter
- SLC9B2 p.Arg339Ser Uncertain significance Single submitter
- SLC9B2 p.Arg71Ile Uncertain significance Single submitter
- SLC9B2 p.Asn302Ser Uncertain significance Single submitter
- SLC9B2 p.Asp41Glu Uncertain significance Single submitter
- SLC9B2 p.Asp473Gly Uncertain significance Single submitter
- SLC9B2 p.Gln70Arg Uncertain significance Single submitter
- SLC9B2 p.Glu11Lys Uncertain significance Single submitter
- SLC9B2 p.Glu386Ala Uncertain significance Single submitter
- SLC9B2 p.Glu480Lys Uncertain significance Single submitter
- SLC9B2 p.Glu528Ala Uncertain significance Single submitter
- SLC9B2 p.Glu532Lys Uncertain significance Single submitter
- SLC9B2 p.Gly128Ser Uncertain significance Single submitter
- SLC9B2 p.Gly153Glu Uncertain significance Single submitter
- SLC9B2 p.Gly210Arg Uncertain significance Single submitter
- SLC9B2 p.Gly266Val Uncertain significance Single submitter
- SLC9B2 p.Gly361Glu Uncertain significance Single submitter
- SLC9B2 p.Gly377Ala Uncertain significance Single submitter
- SLC9B2 p.Gly39Ala Uncertain significance Single submitter
- SLC9B2 p.Gly444Ser Uncertain significance Single submitter
- SLC9B2 p.Gly468Glu Uncertain significance Single submitter
- SLC9B2 p.His356Arg Uncertain significance Single submitter
- SLC9B2 p.His68Leu Uncertain significance Single submitter
- SLC9B2 p.His68Tyr Uncertain significance Single submitter
- SLC9B2 p.His81Arg Uncertain significance Single submitter
- SLC9B2 p.Ile104Ser Uncertain significance Single submitter
- SLC9B2 p.Ile127Val Uncertain significance Single submitter
- SLC9B2 p.Ile135Thr Uncertain significance Single submitter
- SLC9B2 p.Ile427Thr Uncertain significance Single submitter
- SLC9B2 p.Leu115Val Uncertain significance Single submitter
- SLC9B2 p.Leu304Phe Uncertain significance Single submitter
- SLC9B2 p.Leu320Ile Uncertain significance Single submitter
- SLC9B2 p.Leu349Ile Uncertain significance Single submitter
- SLC9B2 p.Leu52Ser Uncertain significance Single submitter
- SLC9B2 p.Lys171Arg Uncertain significance Single submitter
- SLC9B2 p.Met209Thr Uncertain significance Single submitter
- SLC9B2 p.Met376Val Uncertain significance Single submitter
- SLC9B2 p.Phe116Leu Uncertain significance Single submitter
- SLC9B2 p.Phe239Cys Uncertain significance Single submitter
- SLC9B2 p.Phe327Val Uncertain significance Single submitter
- SLC9B2 p.Pro211Arg Uncertain significance Single submitter
- SLC9B2 p.Ser353Gly Uncertain significance Single submitter
- SLC9B2 p.Ser354Ile Uncertain significance Single submitter
- SLC9B2 p.Ser49Gly Uncertain significance Single submitter
- SLC9B2 p.Thr218Ile Uncertain significance Single submitter
- SLC9B2 p.Thr284Pro Uncertain significance Single submitter
- SLC9B2 p.Thr284Ser Uncertain significance Single submitter
- SLC9B2 p.Thr299Ala Uncertain significance Single submitter
- SLC9B2 p.Thr299Ile Uncertain significance Single submitter
- SLC9B2 p.Thr462Ala Uncertain significance Single submitter
- SLC9B2 p.Thr62Ile Uncertain significance Single submitter
- SLC9B2 p.Trp233Leu Uncertain significance Single submitter
- SLC9B2 p.Tyr261Phe Uncertain significance Single submitter
- SLC9B2 p.Val205Ile Uncertain significance Single submitter
- SLC9B2 p.Val319Ile Uncertain significance Single submitter
- SLC9B2 p.Val348Ala Uncertain significance Single submitter
- SLC9B2 p.Val408Leu Uncertain significance Single submitter
- SLC9B2 p.Val418Ile Uncertain significance Single submitter
- SLC9B2 p.Val425Ile Uncertain significance Single submitter
- SLC9B2 p.Val493Ala Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- SLC9B2 p.Ile184Val Uncertain significance Single submitter
- SLC9B2 p.Leu132Trp Uncertain significance Single submitter
- SLC9B2 p.Leu190Ile Uncertain significance Single submitter
- SLC9B2 p.Leu97Pro Uncertain significance Single submitter
- SLC9B2 p.Lys450Asn Uncertain significance Single submitter
- SLC9B2 p.Phe294Leu Uncertain significance Single submitter
- SLC9B2 p.Phe327Leu Uncertain significance Single submitter
- SLC9B2 p.Ser103Pro Uncertain significance Single submitter
- SLC9B2 p.Trp172Leu Uncertain significance Single submitter
- SLC9B2 p.Val336Met Uncertain significance Single submitter
All SLC9B2 variants
Benign 3
- p.Pro415Ala Multiple submitters
- p.Thr379= Multiple submitters
- p.Val267= Multiple submitters
Uncertain significance 75
- p.Ala180Val Single submitter ⚠
- p.Ala350Thr Single submitter ⚠
- p.Ala392Val Single submitter ⚠
- p.Ala456Val Single submitter ⚠
- p.Arg330His Single submitter ⚠
- p.Arg339Ser Single submitter ⚠
- p.Arg71Ile Single submitter ⚠
- p.Asn302Ser Single submitter ⚠
- p.Asp41Glu Single submitter ⚠
- p.Asp473Gly Single submitter ⚠
- p.Gln70Arg Single submitter ⚠
- p.Glu11Lys Single submitter ⚠
- p.Glu386Ala Single submitter ⚠
- p.Glu480Lys Single submitter ⚠
- p.Glu528Ala Single submitter ⚠
- p.Glu532Lys Single submitter ⚠
- p.Gly128Ser Single submitter ⚠
- p.Gly153Glu Single submitter ⚠
- p.Gly210Arg Single submitter ⚠
- p.Gly266Val Single submitter ⚠
- p.Gly361Glu Single submitter ⚠
- p.Gly377Ala Single submitter ⚠
- p.Gly39Ala Single submitter ⚠
- p.Gly444Ser Single submitter ⚠
- p.Gly468Glu Single submitter ⚠
- p.His356Arg Single submitter ⚠
- p.His68Leu Single submitter ⚠
- p.His68Tyr Single submitter ⚠
- p.His81Arg Single submitter ⚠
- p.Ile104Ser Single submitter ⚠
- p.Ile127Val Single submitter ⚠
- p.Ile135Thr Single submitter ⚠
- p.Ile184Val Single submitter ⚠
- p.Ile427Thr Single submitter ⚠
- p.Leu115Val Single submitter ⚠
- p.Leu132Trp Single submitter ⚠
- p.Leu190Ile Single submitter ⚠
- p.Leu304Phe Single submitter ⚠
- p.Leu304Pro Single submitter
- p.Leu320Ile Single submitter ⚠
- p.Leu349Ile Single submitter ⚠
- p.Leu52Ser Single submitter ⚠
- p.Leu97Pro Single submitter ⚠
- p.Lys171Arg Single submitter ⚠
- p.Lys450Asn Single submitter ⚠
- p.Met209Thr Single submitter ⚠
- p.Met376Val Single submitter ⚠
- p.Phe116Leu Single submitter ⚠
- p.Phe239Cys Single submitter ⚠
- p.Phe294Leu Single submitter ⚠
- p.Phe327Leu Single submitter ⚠
- p.Phe327Val Single submitter ⚠
- p.Pro211Arg Single submitter ⚠
- p.Ser103Pro Single submitter ⚠
- p.Ser353Gly Single submitter ⚠
- p.Ser354Ile Single submitter ⚠
- p.Ser49Gly Single submitter ⚠
- p.Thr218Ile Single submitter ⚠
- p.Thr284Pro Single submitter ⚠
- p.Thr284Ser Single submitter ⚠
- p.Thr299Ala Single submitter ⚠
- p.Thr299Ile Single submitter ⚠
- p.Thr462Ala Single submitter ⚠
- p.Thr62Ile Single submitter ⚠
- p.Trp172Leu Single submitter ⚠
- p.Trp233Leu Single submitter ⚠
- p.Tyr261Phe Single submitter ⚠
- p.Val205Ile Single submitter ⚠
- p.Val319Ile Single submitter ⚠
- p.Val336Met Single submitter ⚠
- p.Val348Ala Single submitter ⚠
- p.Val408Leu Single submitter ⚠
- p.Val418Ile Single submitter ⚠
- p.Val425Ile Single submitter ⚠
- p.Val493Ala Single submitter ⚠