SLCO1A2 — 79 ClinVar variants
All ClinVar germline SLCO1A2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
2 Benign · 77 Uncertain significance
Full SLCO1A2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SLCO1A2 p.Ala187Pro Uncertain significance Single submitter
- SLCO1A2 p.Ala187Val Uncertain significance Single submitter
- SLCO1A2 p.Ala203Thr Uncertain significance Single submitter
- SLCO1A2 p.Ala29Val Uncertain significance Single submitter
- SLCO1A2 p.Arg49Lys Uncertain significance Single submitter
- SLCO1A2 p.Arg7Lys Uncertain significance Single submitter
- SLCO1A2 p.Asn111Lys Uncertain significance Single submitter
- SLCO1A2 p.Asn124Ser Uncertain significance Single submitter
- SLCO1A2 p.Asn219Tyr Uncertain significance Single submitter
- SLCO1A2 p.Asn228Ser Uncertain significance Single submitter
- SLCO1A2 p.Asn419His Uncertain significance Single submitter
- SLCO1A2 p.Asn478Thr Uncertain significance Single submitter
- SLCO1A2 p.Asn483Ser Uncertain significance Single submitter
- SLCO1A2 p.Cys314Gly Uncertain significance Single submitter
- SLCO1A2 p.Cys367Gly Uncertain significance Single submitter
- SLCO1A2 p.Cys410Arg Uncertain significance Single submitter
- SLCO1A2 p.Cys465Tyr Uncertain significance Single submitter
- SLCO1A2 p.Cys500Ser Uncertain significance Single submitter
- SLCO1A2 p.Cys575Ser Uncertain significance Single submitter
- SLCO1A2 p.Gln144Arg Uncertain significance Single submitter
- SLCO1A2 p.Gly136Arg Uncertain significance Single submitter
- SLCO1A2 p.Gly179Cys Uncertain significance Single submitter
- SLCO1A2 p.Gly206Asp Uncertain significance Single submitter
- SLCO1A2 p.Gly210Arg Uncertain significance Single submitter
- SLCO1A2 p.Gly560Ser Uncertain significance Single submitter
- SLCO1A2 p.Gly584Asp Uncertain significance Single submitter
- SLCO1A2 p.Gly90Asp Uncertain significance Single submitter
- SLCO1A2 p.Gly92Val Uncertain significance Single submitter
- SLCO1A2 p.His107Asp Uncertain significance Single submitter
- SLCO1A2 p.His389Arg Uncertain significance Single submitter
- SLCO1A2 p.His627Asn Uncertain significance Single submitter
- SLCO1A2 p.Ile166Val Uncertain significance Single submitter
- SLCO1A2 p.Ile322Thr Uncertain significance Single submitter
- SLCO1A2 p.Ile360Met Uncertain significance Single submitter
- SLCO1A2 p.Ile515Val Uncertain significance Single submitter
- SLCO1A2 p.Leu275Arg Uncertain significance Single submitter
- SLCO1A2 p.Leu400Ile Uncertain significance Single submitter
- SLCO1A2 p.Leu546Phe Uncertain significance Single submitter
- SLCO1A2 p.Leu620Phe Uncertain significance Single submitter
- SLCO1A2 p.Leu670Ser Uncertain significance Single submitter
- SLCO1A2 p.Met110Thr Uncertain significance Single submitter
- SLCO1A2 p.Met21Ile Uncertain significance Single submitter
- SLCO1A2 p.Met358Leu Uncertain significance Single submitter
- SLCO1A2 p.Met43Thr Uncertain significance Single submitter
- SLCO1A2 p.Met43Val Uncertain significance Single submitter
- SLCO1A2 p.Met479Thr Uncertain significance Single submitter
- SLCO1A2 p.Phe247Cys Uncertain significance Single submitter
- SLCO1A2 p.Pro365Thr Uncertain significance Single submitter
- SLCO1A2 p.Pro605Leu Uncertain significance Single submitter
- SLCO1A2 p.Ser395Thr Uncertain significance Single submitter
- SLCO1A2 p.Thr143Met Uncertain significance Single submitter
- SLCO1A2 p.Thr150Lys Uncertain significance Single submitter
- SLCO1A2 p.Thr237Ser Uncertain significance Single submitter
- SLCO1A2 p.Thr45Arg Uncertain significance Single submitter
- SLCO1A2 p.Thr55Ala Uncertain significance Single submitter
- SLCO1A2 p.Thr637Lys Uncertain significance Single submitter
- SLCO1A2 p.Thr659Met Uncertain significance Single submitter
- SLCO1A2 p.Tyr566His Uncertain significance Single submitter
- SLCO1A2 p.Val161Ala Uncertain significance Single submitter
- SLCO1A2 p.Val161Ile Uncertain significance Single submitter
- SLCO1A2 p.Val324Ala Uncertain significance Single submitter
- SLCO1A2 p.Val333Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- SLCO1A2 p.Arg240His Uncertain significance Single submitter
- SLCO1A2 p.Cys28Arg Uncertain significance Single submitter
- SLCO1A2 p.Gly503Glu Uncertain significance Single submitter
- SLCO1A2 p.Gly610Arg Uncertain significance Single submitter
- SLCO1A2 p.His107Arg Uncertain significance Single submitter
- SLCO1A2 p.Phe249Val Uncertain significance Single submitter
- SLCO1A2 p.Phe553Cys Uncertain significance Single submitter
All SLCO1A2 variants
Benign 2
- p.Asn256= Multiple submitters
- p.Asn128Tyr Single submitter
Uncertain significance 77
- p.Ala187Pro Single submitter ⚠
- p.Ala187Val Single submitter ⚠
- p.Ala203Thr Single submitter ⚠
- p.Ala29Val Single submitter ⚠
- p.Ala388Thr Single submitter
- p.Ala563Val Single submitter
- p.Arg240His Single submitter ⚠
- p.Arg49Lys Single submitter ⚠
- p.Arg7Lys Single submitter ⚠
- p.Asn111Lys Single submitter ⚠
- p.Asn124Ser Single submitter ⚠
- p.Asn219Tyr Single submitter ⚠
- p.Asn228Ser Single submitter ⚠
- p.Asn419His Single submitter ⚠
- p.Asn478Thr Single submitter ⚠
- p.Asn483Ser Single submitter ⚠
- p.Cys28Arg Single submitter ⚠
- p.Cys314Gly Single submitter ⚠
- p.Cys367Gly Single submitter ⚠
- p.Cys410Arg Single submitter ⚠
- p.Cys465Tyr Single submitter ⚠
- p.Cys500Ser Single submitter ⚠
- p.Cys575Ser Single submitter ⚠
- p.Cys93Ser Single submitter
- p.Gln144Arg Single submitter ⚠
- p.Gly136Arg Single submitter ⚠
- p.Gly179Cys Single submitter ⚠
- p.Gly206Asp Single submitter ⚠
- p.Gly210Arg Single submitter ⚠
- p.Gly417Glu Single submitter
- p.Gly503Glu Single submitter ⚠
- p.Gly560Ser Single submitter ⚠
- p.Gly584Asp Single submitter ⚠
- p.Gly610Arg Single submitter ⚠
- p.Gly90Asp Single submitter ⚠
- p.Gly92Val Single submitter ⚠
- p.His107Arg Single submitter ⚠
- p.His107Asp Single submitter ⚠
- p.His389Arg Single submitter ⚠
- p.His627Asn Single submitter ⚠
- p.Ile166Val Single submitter ⚠
- p.Ile322Thr Single submitter ⚠
- p.Ile360Met Single submitter ⚠
- p.Ile47Thr Single submitter
- p.Ile515Val Single submitter ⚠
- p.Leu105Gln Single submitter
- p.Leu275Arg Single submitter ⚠
- p.Leu400Ile Single submitter ⚠
- p.Leu546Phe Single submitter ⚠
- p.Leu620Phe Single submitter ⚠
- p.Leu670Ser Single submitter ⚠
- p.Met110Thr Single submitter ⚠
- p.Met21Ile Single submitter ⚠
- p.Met358Leu Single submitter ⚠
- p.Met43Thr Single submitter ⚠
- p.Met43Val Single submitter ⚠
- p.Met479Thr Single submitter ⚠
- p.Phe247Cys Single submitter ⚠
- p.Phe249Val Single submitter ⚠
- p.Phe553Cys Single submitter ⚠
- p.Pro365Thr Single submitter ⚠
- p.Pro605Leu Single submitter ⚠
- p.Ser395Thr Single submitter ⚠
- p.Thr143Met Single submitter ⚠
- p.Thr150Lys Single submitter ⚠
- p.Thr237Ser Single submitter ⚠
- p.Thr45Arg Single submitter ⚠
- p.Thr55Ala Single submitter ⚠
- p.Thr637Lys Single submitter ⚠
- p.Thr659Met Single submitter ⚠
- p.Tyr195His Single submitter
- p.Tyr566His Single submitter ⚠
- p.Val161Ala Single submitter ⚠
- p.Val161Ile Single submitter ⚠
- p.Val222Ala Single submitter
- p.Val324Ala Single submitter ⚠
- p.Val333Ile Single submitter ⚠