Sugi Variant

Sugi Variant/SLCO1B1

SLCO1B1 — 221 ClinVar variants

All ClinVar germline SLCO1B1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →

2 Pathogenic · 5 Likely pathogenic · 4 Conflicting · 51 Benign · 6 Benign/Likely benign · 39 Likely benign · 114 Uncertain significance

Full SLCO1B1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 84

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 75

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 8

The independent predictors disagree with each other — read with care.

All SLCO1B1 variants

Pathogenic 2

  • p.Arg253Ter Multiple submitters SLCO1B1-related disorder
  • p.Arg580Ter Multiple submitters SLCO1B1-related disorder

Likely pathogenic 5

Conflicting classifications of pathogenicity 4

Benign 51

Benign/Likely benign 6

Likely benign 39

Uncertain significance 114