Sugi Variant

Sugi Variant/SLCO1B3

SLCO1B3 — 300 ClinVar variants

All ClinVar germline SLCO1B3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 137 flagged for review →

3 Pathogenic · 4 Likely pathogenic · 12 Conflicting · 50 Benign · 6 Benign/Likely benign · 46 Likely benign · 179 Uncertain significance

Full SLCO1B3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 137

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 5

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 108

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 24

The independent predictors disagree with each other — read with care.

All SLCO1B3 variants

Pathogenic 3

Likely pathogenic 4

Conflicting classifications of pathogenicity 12

Benign 50

Benign/Likely benign 6

Likely benign 46

Uncertain significance 179