SLCO2B1 — 92 ClinVar variants

All ClinVar germline SLCO2B1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →

4 Benign · 8 Likely benign · 80 Uncertain significance

Full SLCO2B1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 76

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 68

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 8

The independent predictors disagree with each other — read with care.

All SLCO2B1 variants

Benign 4

p.Pro135= Multiple submitters
p.Val697= Multiple submitters
p.Gly429= Single submitter
p.Phe51= Single submitter

Likely benign 8

p.Arg271= Multiple submitters
p.Arg635His Single submitter
p.Cys504= Single submitter
p.Gly443Ser Single submitter
p.Ser420Leu Single submitter
p.Tyr120Cys Single submitter
p.Val40Leu Single submitter
p.Val430Ile Single submitter

Uncertain significance 80

p.Ala290Pro Single submitter ⚠
p.Ala471Val Single submitter ⚠
p.Ala667Thr Single submitter ⚠
p.Arg143Cys Single submitter ⚠
p.Arg143His Single submitter ⚠
p.Arg250Cys Single submitter ⚠
p.Arg250His Single submitter ⚠
p.Arg306Cys Single submitter ⚠
p.Arg369His Single submitter ⚠
p.Arg41Gln Single submitter ⚠
p.Arg41Trp Single submitter ⚠
p.Asn174Ile Single submitter ⚠
p.Asn350Thr Single submitter ⚠
p.Asn538Ser Single submitter ⚠
p.Asp342Gly Single submitter ⚠
p.Asp505Asn Single submitter ⚠
p.Gln476His Single submitter ⚠
p.Gln693Glu Single submitter ⚠
p.Glu10Val Single submitter ⚠
p.Glu300Gln Single submitter ⚠
p.Gly285Arg Single submitter ⚠
p.Gly464Ser Single submitter ⚠
p.Gly619Ser Single submitter ⚠
p.Gly661Ser Single submitter ⚠
p.Gly661Val Single submitter ⚠
p.Gly81Arg Single submitter
p.His185Tyr Single submitter ⚠
p.His370Asp Single submitter ⚠
p.Ile118Thr Single submitter ⚠
p.Ile123Asn Single submitter
p.Ile206Val Single submitter ⚠
p.Ile211Val Single submitter ⚠
p.Ile229Asn Single submitter ⚠
p.Ile652Val Single submitter ⚠
p.Leu101Phe Single submitter ⚠
p.Leu124Phe Single submitter ⚠
p.Leu447Pro Single submitter ⚠
p.Leu458Pro Single submitter ⚠
p.Leu646Val Single submitter ⚠
p.Leu670Ser Single submitter ⚠
p.Leu69Pro Single submitter ⚠
p.Met192Thr Single submitter ⚠
p.Met248Val Single submitter ⚠
p.Met390Thr Single submitter ⚠
p.Met584Ile Single submitter ⚠
p.Phe356Val Single submitter ⚠
p.Pro135Leu Single submitter ⚠
p.Pro205Ser Single submitter ⚠
p.Pro238Ser Single submitter ⚠
p.Pro298Ala Single submitter ⚠
p.Pro29Ala Single submitter ⚠
p.Pro361Ser Single submitter ⚠
p.Pro371Arg Single submitter
p.Pro487Ser Single submitter ⚠
p.Pro515His Single submitter ⚠
p.Pro547His Single submitter ⚠
p.Pro563Thr Single submitter ⚠
p.Ser139Leu Single submitter ⚠
p.Ser166Leu Single submitter ⚠
p.Ser187Arg Single submitter ⚠
p.Ser330Cys Single submitter ⚠
p.Ser56Gly Single submitter ⚠
p.Thr147Asn Single submitter ⚠
p.Thr164Lys Single submitter ⚠
p.Thr165Ser Single submitter ⚠
p.Thr318Ala Single submitter ⚠
p.Thr338Met Single submitter ⚠
p.Thr367Ile Single submitter ⚠
p.Thr508Ile Single submitter ⚠
p.Thr75Ile Single submitter ⚠
p.Thr86Met Single submitter ⚠
p.Tyr144Asp Single submitter
p.Tyr180Cys Single submitter ⚠
p.Tyr408His Single submitter ⚠
p.Val194Ala Single submitter ⚠
p.Val381Glu Single submitter ⚠
p.Val381Ile Single submitter ⚠
p.Val423Met Single submitter ⚠
p.Val426Met Single submitter ⚠
p.Val440Leu Single submitter ⚠