Sugi Variant

Sugi Variant/SLF2

SLF2 — 182 ClinVar variants

All ClinVar germline SLF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 151 flagged for review →

5 Pathogenic · 3 Likely pathogenic · 1 Conflicting · 1 Benign · 20 Likely benign · 152 Uncertain significance

Full SLF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 151

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 135

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 15

The independent predictors disagree with each other — read with care.

All SLF2 variants

Pathogenic 5

Likely pathogenic 3

Conflicting classifications of pathogenicity 1

Benign 1

Likely benign 20

Uncertain significance 152